Patents by Inventor Wu Du

Wu Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS
    Publication number: 20100184799
    Abstract: Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.
    Type: Application
    Filed: January 12, 2010
    Publication date: July 22, 2010
    Inventors: WU DU, WILLIAM K. HAGMANN, SHUWEN HE, ZHONG LAI, SHRENIK K. SHAH, QUANG T. TRUONG
  • BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS
    Publication number: 20100184758
    Abstract: Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.
    Type: Application
    Filed: July 15, 2008
    Publication date: July 22, 2010
    Inventors: Peter H. Dobbelaar, Wu Du, Liangqin Guo, William K. Hagmann, Shuwen He, Tianying Jian, Jian Liu, Ravi P. Nargund, Alexander Pasternak, Shrenik K. Shah, Quang T. Truong, Zhixiong Ye, James Deliureficio, Raman Bakshi
  • Highly lipophilic camptothecin intermediates and prodrugs and methods of preparation thereof
    Patent number: 7064206
    Abstract: The present invention relates to novel, highly lipophilic silatecan intermediates and prodrugs of DB-67 and other silatecans.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: June 20, 2006
    Assignees: University of Kentucky Research Foundation, University of Pittsburg
    Inventors: Lori Latus, legal representative, Dennis P. Curran, Wu Du, Thomas G. Burke, deceased
  • Camptothecin intermediates and prodrugs and methods of preparation thereof
    Patent number: 7064202
    Abstract: The present invention relates to novel intermediates and prodrugs of camptothecin and related analogs.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: June 20, 2006
    Assignees: University of Kentucky Research Foundation, University of Pittsburgh
    Inventors: Thomas G. Burke, deceased, Dennis P. Curran, Wu Du
  • Synthesis of silyl camptothecins and silyl homocamptothecins
    Patent number: 6372906
    Abstract: A method of synthesizing 7-silyl camptothecins and 7-silyl homocamptothecins includes the step of mixing a camptothecin or a homocamptothecin having hydrogen at the C7 position with a silyl radical generator and a silyl radical precursor under conditions to generate a silyl radical. SiR1R2R3 wherein R1, R2 and R3 are independently a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, an aryl group, —(CH2)mR11 or SiR12R13R14, wherein m is an integer within the range of 1 through 10 and R11 is a hydroxy group, an alkoxy group, an amino group, an alkylamino group, a dialkylamino group, F, Cl, a cyano group, —SRc or a nitro group, and wherein R12, R13 and R14 are independently the same or different an alkyl group or an aryl group.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: April 16, 2002
    Assignee: University of Pittsburgh
    Inventors: Dennis P. Curran, Wu Du
  • Braiding machine having self-propelled bobbin carriers
    Patent number: 4972756
    Abstract: A simple braiding machine readily adaptable to a variety of braiding tasks comprises self-propelled bobbin carriers guided by a track consisting of interchangeable units similar to the interchangeable track units of a toy train. Also disclosed is a simple yarn tensioner capable of maintaining constant tension in the braiding yarn and capable of taking up slack yarn.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: November 27, 1990
    Assignee: University of Delaware
    Inventors: Guang-Wu Du, Timothy D. Kostar