Patents by Inventor Wulin Liu

Wulin Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cycloastragenol monoglucoside, preparation, pharmaceutical composition and application thereof
    Patent number: 8835134
    Abstract: This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-?-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-?-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: September 16, 2014
    Assignee: Tianjin Institute of Pharmaceutical Research
    Inventors: Yingmei Han, Guangping Xia, Weiren Xu, Zhuanyou Zhao, Wulin Liu, Naxia Zhao, Peng Liu, Shijun Zhang, Xiaoli Fu, Yuli Wang, Weiting Wang, Lida Tang
  • CYCLOASTRAGENOL MONOGLUCOSIDE, PREPARATION, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
    Publication number: 20110218161
    Abstract: This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-?-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-?-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
    Type: Application
    Filed: September 8, 2008
    Publication date: September 8, 2011
    Applicant: Tianjin Institute of Pharmaceutical Research
    Inventors: Yingmei Han, Guangping Xia, Weiren Xu, Zhuanyou Zhao, Wulin Liu, Naxia Zhao, Peng Liu, Shijun Zhang, Xiaoli Fu, Yuli Wang, Weiting Wang, Lida Tang