Abstract: The present disclosure provides methods for modifying gluten polypeptides to produce gluten polypeptides with a reduced inflammatory potential, as well as modified plants and compositions comprising modified gluten polypeptides with a reduced inflammatory potential.

Abstract: The invention disclosed herein comprises peptides designed to include an amino acid sequence that confers such peptides with an ability to induce positive Gaussian curvature (and/or an ability to inhibit negative Gaussian curvature) in mammalian cell membranes. The invention disclosed herein further includes methods of using such peptides, for example as a non-hormonal contraceptive, an antiviral agent, an anti-inflammatory agent, or a therapeutic agent which can, for example, reduce neurotransmitter or hormone secretion in order to treat neuropsychiatric or endocrine disorders.

Abstract: Compositions and methods are disclosed that relate to aminoglycoside-linker-peptide (P-L-A) conjugates having unexpectedly advantageous dual-function bactericidal properties. Encompassed compounds are shown to be capable of energy independent bacterial plasma membrane disruption and to exhibit potent toxicity to bacteria including antibiotic-resistant bacteria. These and related embodiments will find uses for treating bacterial infections including overcoming antibiotic resistance.

Abstract: The invention comprises charge modified antimicrobials, including charge modified lysozymes, as well as compositions and methods for potentiating antimicrobial activity by modifying a net charge level of the antimicrobial. Also provided is a method of treating microbial infections, including infections associated with cystic fibrosis, comprising administering or co-administering a compound of the invention. The invention provides compositions and methods of potentiating antibiotic treatment by administration of an at least partially cationic or positively-charged surfactant composition. Cationic lipid compositions including DOTAP:DOPE formulations are disclosed.