Patents by Inventor Wulf Merkel

Wulf Merkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5145867
    Abstract: Naphthylalkylamino-substituted sulfamoylbenzoic acid derivatives, processes for the preparation thereof and the use thereof as medicines.Compounds I ##STR1## R(1) hydrogen, (C.sub.1 -C.sub.4)-alkyl and Na, K, NH.sub.4, Ca, Mg, R(2) and R(3) hydrogen, alkyl groups which can also be linked together in a ring,X oxygen, sulfur, SO, SO.sub.2, NR(6) [with R(6)=hydrogen-alkyl], CH.sub.2, CO, or a bond,R(4) phenyl, thienyl, which are unsubstituted or substitutedR(5) hydrogen, (C.sub.1 -C.sub.4)-alkyl,n 1, 2, 3 or 4,where the naphthyl system is unsubstituted or substituted like the phenyl radical of R(4),and where X and R(4) together can also be Cl are medicaments for treating sickle-cell anemia.
    Type: Grant
    Filed: April 6, 1990
    Date of Patent: September 8, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: John C. Ellory, Heinrich C. Englert, Hans-Jochen Lang, Dieter Mania, Wulf Merkel
  • Patent number: 4492710
    Abstract: What are disclosed are pyrrolidinylsulfamoylbenzoic acid compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 denote C.sub.1 -C.sub.4 alkyl and one of the radicals R.sup.1 or R.sup.2 may be hydrogen, R.sup.3 and R.sup.3' denote hydrogen or C.sub.1 -C.sub.4 alkyl or together denote a C--C linkage, R.sup.4 and R.sup.4' denote hydrogen, halogen, CF.sub.3, alkyl or C.sub.1 -C.sub.2 alkoxy, hydroxy, amino or dimethylamino in the various positions of the aryl nucleus, or together denote 3,4-methylenedioxy, R.sup.5 and R.sup.6 denote hydrogen, C.sub.1 -C.sub.4 alkyl or benzyl, Ar denotes phenyl or a 5-membered or 6-membered heteroaromatic ring containing a O, S or N atom and X is omitted or denotes oxygen, sulfur, NH, or CH.sub.2, and their pharmaceutically acceptable salts with bases or acids. The compounds and salts have a salidiuretic action and can be used for the treatment of edematous diseases.
    Type: Grant
    Filed: September 22, 1982
    Date of Patent: January 8, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wulf Merkel, Dieter Bormann, Roman Muschaweck
  • Patent number: 4393072
    Abstract: The invention provides thienylbenzoic acid derivatives of the formula I ##STR1## in which R.sup.1 is an alkyl radical having from 1 to 3 carbon atoms, a phenyl, thienyl or furyl radical optionally substituted by halogen, CF.sub.3, CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydrogen, halogen or CH.sub.3 ; R.sup.3 is hydrogen or alkyl having from 1 to 4 carbon atoms or benzyl; and n is 1 or 2; and the pharmaceutically tolerable salts thereof with acids or bases.
    Type: Grant
    Filed: September 16, 1982
    Date of Patent: July 12, 1983
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wulf Merkel, Dieter Bormann, Dieter Mania, Roman Muschaweck
  • Patent number: 4172142
    Abstract: Salidiuretically-active 3-pyrrolo-5-sulfamoylbenzoic acids having a methylphenoxy or chlorophenoxy group substituted in the 4-position, and alkyl esters thereof, are disclosed, as are methods of making and using the same.
    Type: Grant
    Filed: December 21, 1977
    Date of Patent: October 23, 1979
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wulf Merkel, Dieter Bormann, Dieter Mania, Roman Muschaweck
  • Patent number: 4128643
    Abstract: (2-Amino-4-quinazolinyl)-quanidines of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n have the defined meanings, and their physiologically tolerable acid addition salts, process for preparing these compounds, pharmaceutical preparations containing them and their use as medicines.
    Type: Grant
    Filed: May 26, 1977
    Date of Patent: December 5, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wulf Merkel, Hans G. Alpermann, Karl Geisen, Norbert Kothe, Walter Ried
  • Patent number: 4118397
    Abstract: A process is disclosed for preparing 5-sulfamoylbenzoic acid derivatives substituted in 4-position by various substituents and in 3-position by a cyclic amino group and having sali-diuretic properties. Novel intermediate compounds are also disclosed.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: October 3, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter Bormann, Wulf Merkel, Roman Muschaweck
  • Patent number: 4111953
    Abstract: A process is disclosed for preparing 5-sulfamoylbenzoic acids substituted in 4-position by various substituents and in 3-position by a cyclic amino group having sali-diuretic properties. Novel intermediate compounds are also disclosed.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: September 5, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter Bormann, Wulf Merkel, Dieter Mania
  • Patent number: 4093735
    Abstract: 5-Sulfamoylbenzoic acids substituted in 4-position by various substituents and in 3-position by a cyclic amino group having sali-diuretic properties.
    Type: Grant
    Filed: November 10, 1976
    Date of Patent: June 6, 1978
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter Bormann, Wulf Merkel, Roman Muschaweck
  • Patent number: 4010273
    Abstract: 5-Sulfamoylbenzoic acids substituted in 4-position by various substituents and in 3-position by a cyclic amino group having sali-diurectic properties, and a process for their manufacture.
    Type: Grant
    Filed: April 23, 1975
    Date of Patent: March 1, 1977
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter Bormann, Wulf Merkel, Roman Muschaweck
  • Patent number: 3991097
    Abstract: 3-Alkylamino-5-sulfamyl benzoic acid derivatives are prepared by reducing 3-acylamino-5-sulfamyl-benzoic acid derivatives by means of boron hydrides or complex boron hydrides in the presence of Lewis acids.
    Type: Grant
    Filed: September 5, 1974
    Date of Patent: November 9, 1976
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dieter Bormann, Wulf Merkel