Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

Abstract: This invention relates to a novel direct drive can opener. More particularly, the invention is directed to a novel direct drive can opener which can be operated by hand or by motor, accommodates various sizes of cans and cuts the outer seam wall of a can, rather than the top lid of the can. A can opener comprising: (a) a rotatable cutting wheel having a serially notched cutting edge for severing a first side of a can seam of a can; (b) a rotatable traction wheel having a gripping surface for engaging a second side of the can seam opposite the cutting wheel; (c) a rotary handle associated with said traction wheel for rotating said traction wheel; and (d) a second member for engaging or disengaging said cutting wheel and said traction wheel, on said can seam, the cutting wheel axis and the traction wheel axis being substantially parallel when the first member is engaged with the second member.