Patents by Inventor Wun-Huei Lin

Wun-Huei Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody-drug conjugates and uses thereof
    Patent number: 11384150
    Abstract: An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: July 12, 2022
    Assignees: Development Center for Biotechnology, Tunghai University
    Inventors: Shih-Hsien Chuang, Wei-Ting Chao, Wei-Ting Sun, Hui-Jan Hsu, Wun-Huei Lin
  • ANTIBODY-DRUG CONJUGATES CONTAINING AN ANTI-MESOTHELIN ANTIBODY AND USES THEREOF
    Publication number: 20210386866
    Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.
    Type: Application
    Filed: June 4, 2021
    Publication date: December 16, 2021
    Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: SHIH-HSIEN CHUANG, WEI-TING SUN, YING-SHUAN LAILEE, CHUN-LIANG LAI, WUN-HUEI LIN, WIN-YIN WEI, SHIH-CHONG TSAI, CHENG-CHOU YU, CHAO-YANG HUANG
  • ANTIBODY PROTAC CONJUGATES
    Publication number: 20210015942
    Abstract: An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.
    Type: Application
    Filed: January 9, 2019
    Publication date: January 21, 2021
    Applicant: Development Center for Biotechnology
    Inventors: Shih-Hsien Chuang, Chu-Bin Liao, Wei-Ting Sun, Chen-Hsien Liang, Wun-Huei Lin, Chun-Liang Lai, Her-Sheng Lin
  • ANTIBODY-DRUG CONJUGATES AND USES THEREOF
    Publication number: 20200190199
    Abstract: An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.
    Type: Application
    Filed: December 13, 2017
    Publication date: June 18, 2020
    Inventors: Shih-Hsien Chuang, Wei-Ting Chao, Wei-Ting Sun, Hui-Jan Hsu, Wun-Huei Lin