Patents by Inventor Wuu Jyh Lin
Wuu Jyh Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20130072672Abstract: The present invention establishes a fast and simple [F-18] FLT synthesis process. Solid extraction units are used for purification to achieve an equally high and constant radiochemical yield and purity in a short period of time. By using a separation method, the impurities are reduced successfully while the total synthesis time is shortened. The radiochemical purity and the corrected radiochemical yield are both high.Type: ApplicationFiled: September 20, 2011Publication date: March 21, 2013Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCHInventors: Li-Yuan Huang, Yen-Hung Tu, Wen-Chin Su, Jenn-Tzong Chen, Ting-Shien Duh, Wuu-Jyh Lin
-
Publication number: 20120259102Abstract: A 18F-labeled monomeric galactose derivative is provided as a tomography probe. The derivative is a positron emission tomography (PET) probe. The derivative has high affinity and good stability in animal's body. The derivative can be an alternative glucose metabolism imaging agent used in clinic examination and quantification.Type: ApplicationFiled: April 7, 2011Publication date: October 11, 2012Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCHInventors: Ting-Shien Duh, Wuu-Jyh Lin, Jenn-Tzong Chen, Li-Yuan Huang, Hsin-Ell Wang, Chuan-Lin Chen, Wen-Yi Chang, Hao-Wen Kao
-
Publication number: 20120178919Abstract: A radiolabeled nucleoside analogue is provided, which includes radioactive iodine 123I/131I, and a nucleoside analogue selected from a group consisting of cytidine, thymidine, uridine, and a derivative thereof. A method for preparing the radiolabeled nucleoside analogue, and a use thereof are further provided. The nucleoside analogue, prepared through the preparation method with a short synthesis time and a high radiochemical yield, has a long in vivo physiological half life and a high stability in serum, and, as a radiopharmaceutical composition, is useful in development of tumor proliferation diagnosis or therapy prognosis evaluation, and further assists in observation of long-time in vivo metabolism of a drug.Type: ApplicationFiled: July 29, 2011Publication date: July 12, 2012Applicants: NATIONAL YANG-MING UNIVERSITY, Institute of Nuclear Energy Research Atomic Energy Council, Executive YuanInventors: HSIN-ELL WANG, CHIH-YUAN LIN, WEI-TI KUO, CHUAN-LIN CHEN, MEI-HUI WANG, HUNG-MAN YU, MAO-CHI WENG, YU CHANG, WUU-JYH LIN
-
Patent number: 8181677Abstract: An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.Type: GrantFiled: October 8, 2007Date of Patent: May 22, 2012Assignee: Institute of Nuclear Energy ResearchInventors: Ming-Hsin Li, Wuu-Jyh Lin, Tain-Shi Zen
-
Publication number: 20120107236Abstract: The present invention is related to a pharmaceutical composition for a liver-receptor imaging injection, the pharmaceutical composition including a bi-functional compound which has a ASGPR specificity, wherein the bi-functional compound includes a backbone of alpha-amino acid (or the derivatives thereof) and a poly-galactosamine chain (or a poly-lactose chain) connected to the alpha-amino acid. Thereby, the pharmaceutical composition can quantify potential of liver storage ability and evaluate severity of the course of liver disease. A liver-receptor imaging injection using the same and the one-step dispensing method thereof are also provided to improve defects of iodine-labeled and overcome disadvantages of the reduced labeling-yield and the instability after autoclave sterilization.Type: ApplicationFiled: September 23, 2011Publication date: May 3, 2012Applicant: Institute of Nuclear Energy Research Atomic Energy Council, Executive YuanInventors: MEI-HUI WANG, Wuu-Jyh Lin, Hung-Man Yu, Chuan-Yi Chien, Ping-Yen Wang
-
Patent number: 8157998Abstract: Disclosed is a device for separating radioisotope thallium-201. The device includes an evaporation unit for a solution vial, a first glass vial connected to a first valve and a second valve, an ion exchange column connected to a third valve, a second glass vial connected to a fourth valve and a fifth valve, a collection vial for receiving solution from the fifth valve, a product vial with a membrane filter and a vacuum unit connected to the first valve, the fourth valve and a sixth valve. This device can separate out high-concentration thallium-201 solution from which radioisotope thallium-201 can be obtained.Type: GrantFiled: November 19, 2009Date of Patent: April 17, 2012Assignee: Atomic Energy Council—Institute of Nuclear Energy ResearchInventors: Wuu-Jyh Lin, Jenn-Tzong Chen, Sun-Rong Huang, Ying-Ming Tsai, Jainn-Hsin Lu
-
Patent number: 8142759Abstract: The invention discloses one glyco-molecular imaging method for grade classification of liver fibrosis and its glyco-molecular imaging agent. The agent combining with glyco-molecular imaging method for liver targeting could be used to differentiate the grade of liver fibrosis and follow-up evaluation of the therapeutic effect.Type: GrantFiled: December 12, 2007Date of Patent: March 27, 2012Assignee: Institute of Nuclear Energy ResearchInventors: Mei-Hui Wang, Wuu-Jyh Lin, Shui-Cheng Lee, Lie-Hang Shen, Haw-Jan Chen
-
Patent number: 8043584Abstract: Cd-112 isotope is recycled from a Cd-112 chemical separated solution or a remainder of an electroplating solution having a Cd-112 target. The present invention recycles Cd-112 isotope with a low cost, a high purity and a high recycle rate. The recycled Cd-112 isotope can be easily stored. And, the Cd-112 isotope can be used as an imaging agent in nuclear medicine.Type: GrantFiled: June 22, 2007Date of Patent: October 25, 2011Assignee: Atomic Energy Council - Institute of Nuclear Energy ResearchInventors: Wuu-Jyh Lin, Song-Un Tang
-
Publication number: 20110214995Abstract: Disclosed is a method for making carrier-free radioactive isotopic gallium-67. Stable isotopic zinc-68 is turned into zinc-68 solid target by disposition or electroplating. Then, the zinc-68 solid target is subjected to a proton beam. A cyclotron is used to provide irradiation from 15 to 40 MeV. After the irradiation, the zinc-68 solid target is dissolved in concentrated acid and turned into solution that contains zinc-65, zinc-68, gallium-67 and gallium-68. High concentrated hydrochloric acid and resin are added into the solution for exchange of ions. Zinc-68 liquid and gallium-67 liquid are filtered and separated from the solution. Thus, pure gallium-67 liquid is produced. With a vaporizer, the gallium-67 liquid is vaporized and turned into radioactive isotopic gallium-67.Type: ApplicationFiled: March 5, 2010Publication date: September 8, 2011Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCHInventors: Sun-Rong Huang, Ying-Ming Tsai, Jainn-Hsin Lu, Jenn-Tzong Chen, Wuu-Jyh Lin
-
Patent number: 8007730Abstract: An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.Type: GrantFiled: June 5, 2009Date of Patent: August 30, 2011Assignee: Institute of Nuclear Energy ResearchInventors: Ming-Hsin Li, Hsin-EII Wang, Chun-Yi Wu, Wuu-Jyh Lin
-
Publication number: 20110178325Abstract: Disclosed is an automatic process for synthesizing F-18-FDDNP. The automatic process includes a preparation subroutine and a synthesis subroutine. The automatic process is efficient and simple. That is, it can be used to produce a large amount of chemicals in a short period of time. Furthermore, it reduces the risk of human exposure to radiation.Type: ApplicationFiled: January 18, 2010Publication date: July 21, 2011Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCHInventors: Kang-Wei Chang, Yen-Hung Tu, Shih-Ying Lee, Jenn-Tzong Chen, Chia-Chieh Chen, Wuu-Jyh Lin
-
Publication number: 20110108429Abstract: Cd-112 isotope is recycled from a Cd-112 chemical separated solution or a remainder of an electroplating solution having a Cd-112 target. The present invention recycles Cd-112 isotope with a low cost, a high purity and a high recycle rate. The recycled Cd-112 isotope can be easily stored. And, the Cd-112 isotope can be used as an imaging agent in nuclear medicine.Type: ApplicationFiled: June 22, 2007Publication date: May 12, 2011Applicant: ATOMIC ENERGY COUNCIL - INSTITUTE OF NUCLEAR ENERGY RESEARCHInventors: Wuu-Jyh Lin, Song-Un Tang
-
Publication number: 20110097265Abstract: A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining liver function to serve as test indicator for judging the liver failure outcome in clinic, particularly for judging the necessity of liver transplantation for patients with liver failure or liver disease. The radioactivity uptake of the test indicator was negatively correlated with the extent of liver reserve. The cutoff value of liver reserve for liver transplantation is also disclosed.Type: ApplicationFiled: May 13, 2010Publication date: April 28, 2011Applicant: Institute of Nuclear Energy Research Atomic Energy Council, Executive YuanInventors: Mei-Hui Wang, Wuu-Jyh Lin, Chuan-Yi Chien, Hung-Man Yu, Reiko Takasaka Lee, Yuan-Chuan Lee
-
Publication number: 20110097264Abstract: A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent is provided. The multivalent glycoligand-DTPA derivatives (In-111-DTPA-hexa lactoside and In-111-DTPA-tri-galactosamine glycoside) labeled with In-111 are used as hepatic receptor imaging agent. The effects of imaging of a hepatic receptor in different species are evaluated, the lowest specific radioactivity values of hepatic receptor imaging required in different species are discovered. Since the specificity of the human ASGPR closely resembles that of the mouse. This kind of radiolabelling method, agent and related study about specific radioactivity could be used in clinical trial in the future.Type: ApplicationFiled: May 13, 2010Publication date: April 28, 2011Applicant: Institute of Nuclear Energy Research Atomic Energy Council, Executive YuanInventors: Mei-Hui Wang, Wuu-Jyh Lin, Chuan-Yi Chien, Hung-Man Yu, Reiko Takasaka Lee, Yuan-Chuan Lee
-
Publication number: 20110077386Abstract: This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilo triacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in N?-benzyloxycarbonyl-N?-dicarboxymethyl-L-lysine can be conjugated with three glycosides of ahGalNAc or ahLac in one step. This invention also provides a hexa-lactoside. In particular, the TFA-AHA-Asp was used to conjugate 2 moles of NTA(ahLac)3. This invention also provides a method for adding a spacer between NTA and DTPA. The extended hepatocyte-specific glyco-ligand has higher 111In-radiolabelling yield than those non-extended.Type: ApplicationFiled: September 27, 2010Publication date: March 31, 2011Applicants: JOHNS HOPKINS UNIVERSITY, Institute of Nuclear Energy Research Atomic Energy Council, Executive YuanInventors: REIKO TAKASAKA LEE, YUAN-CHUAN LEE, MEI-HUI WANG, WUU-JYH LIN
-
Publication number: 20100320136Abstract: Disclosed is a device for separating radioisotope thallium-201. The device includes an evaporation unit for a solution vial, a first glass vial connected to a first valve and a second valve, an ion exchange column connected to a third valve, a second glass vial connected to a fourth valve and a fifth valve, a collection vial for receiving solution from the fifth valve, a product vial with a membrane filter and a vacuum unit connected to the first valve, the fourth valve and a sixth valve. This device can separate out high-concentration thallium-201 solution from which radioisotope thallium-201 can be obtained.Type: ApplicationFiled: November 19, 2009Publication date: December 23, 2010Applicant: Atomic Energy Council- Institute of Nuclear Energy ResearchInventors: Wuu-Jyh Lin, Jenn-Tzong Chen, Sun-Rong Huang, Ying-Ming Tsai, Jainn-Hsin Lu
-
Patent number: 7854090Abstract: Through a low-dose irradiation, a seaweed's growth becomes fast and its production is improved as well. By doing so, a material for biomass energy is provided.Type: GrantFiled: July 3, 2006Date of Patent: December 21, 2010Assignee: Atomic Energy Council-Institute of Nuclear Energy ResearchInventors: Yean-Chang Chen, Chia-Chieh Chen, Kuan-Yin Chen, Hsueh-Hsuan Liu, Bin Lin, Meng-Chou Lee, Ming-Chao Kuo, Wen-Song Hwang, Ying-Kai Fu, Wuu-Jyh Lin, Lie-Hang Shen
-
Publication number: 20100310428Abstract: An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.Type: ApplicationFiled: June 5, 2009Publication date: December 9, 2010Inventors: MING-HSIN LI, HSIN-EII WANG, CHUN-YI WU, WUU-JYH LIN
-
Publication number: 20100243082Abstract: A liquid isotope delivery system includes a pressure-controlling unit, an input unit, a target chamber, a proton-radiating unit and a storage unit. The pressure-controlling unit includes a first regulating valve, a second regulating valve connected to the first regulating valve and a third regulating valve connected to the first regulating valve. The input unit is connected to the second regulating valve. The target chamber is connected to the third regulating valve and the input unit. The proton-radiating unit is located near the target chamber. The storage unit is connected to the target chamber.Type: ApplicationFiled: October 31, 2007Publication date: September 30, 2010Applicant: ATOMIC ENERGY COUNCIL - INSTITUTE OF NUCLEAR ENERGY RESEARCHInventors: Wuu-Jyh Lin, Mao-Hsung Chang, Kuo-Yuan Chu, Dow-chi Chen, Ping-Yen Huang, Jenn-Tzong Chen, Ting-shien Duh
-
Publication number: 20100236141Abstract: Through a low-dose irradiation, a seaweed's growth becomes fast and its production is improved as well. By doing so, a material for biomass energy is provided.Type: ApplicationFiled: July 3, 2006Publication date: September 23, 2010Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCHInventors: Chia-Chieh Chen, Yean-Chang Chen, Kuan-Yin Chen, Hsueh-Hsuan Liu, Bin Lin, Meng-Chou Lee, Ming-Chao Kuo, Wen-Song Hwang, Ying-Kai Fu, Wuu-Jyh Lin, Lie-Hang Shen