Patents by Inventor Wyeth
Wyeth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9545454Abstract: Isolated polynucleotides comprising a S100B mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: GrantFiled: July 24, 2015Date of Patent: January 17, 2017Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Charles de Leeuw, Wyeth W. Wasserman, Daniel Goldowitz
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Patent number: 9546357Abstract: Isolated polynucleotides comprising a UGT8 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: GrantFiled: March 11, 2015Date of Patent: January 17, 2017Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Cletus D'Souza, Charles de Leeuw, Daniel Goldowitz, Robert A. Holt, Elodie Portales-Casamar, Vikramjit Chopra, Wyeth W. Wasserman, Steven J. Jones
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Publication number: 20160340690Abstract: Isolated polynucleotides comprising a NOV mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, including, but not limited to, reporter genes, genes encoding a polypeptide of interest, and regulatory RNA sequences such as miRNA, siRNA, and anti-sense RNA. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, including, but not limited to, for identifying or labeling cells, monitoring or tracking the expression of cells and gene therapy.Type: ApplicationFiled: May 20, 2016Publication date: November 24, 2016Inventors: Elizabeth M. Simpson, Charles de Leeuw, Daniel Goldowitz, Wyeth W. Wasserman
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Publication number: 20160030597Abstract: Isolated polynucleotides comprising a S100B mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: July 24, 2015Publication date: February 4, 2016Inventors: Elizabeth M. Simpson, Charles de Leeuw, Wyeth W. Wasserman, Daniel Goldowitz
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Publication number: 20150374292Abstract: A device for detecting spatial differences in fluid level changes in a tissue of a patient may include a support structure for securing the device to a body part of the patient, a processing element operably connected to the support structure, a wireless networking interface operably connected to the support structure and in communication with the processing element and an external computing device via a network, a first transmission module operably connected to the support structure and in communication with the processing element, a second transmission module and a third transmission module operably connected to the support structure and in communication with the processing element. When activated, the first transmission module transmits a first time varying magnetic field through the tissue of the patient. The second and third transmission modules, which are spatially separated from one another, receive first and second versions, respectively, of the first time varying magnetic field.Type: ApplicationFiled: September 3, 2015Publication date: December 31, 2015Inventors: Richard Warren WYETH, Mitchell Elliott Levinson, Bryan Jon Weber, Eugene Mark Shusterman, Boris Rubinsky
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Publication number: 20150343020Abstract: Isolated polynucleotides comprising a TNNT1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: May 28, 2015Publication date: December 3, 2015Inventors: Elizabeth M. Simpson, Vikramjit Chopra, Cletus D'Souza, Charles de Leeuw, Daniel Goldowitz, Robert A. Holt, Steven J. Jones, Elodie Portales-Casamar, Wyeth W. Wasserman
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Publication number: 20150315609Abstract: Isolated polynucleotides comprising a SLC6A4 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: May 4, 2015Publication date: November 5, 2015Inventors: Elizabeth M. Simpson, Cletus D'Souza, Charles de Leeuw, Daniel Goldowitz, Robert A. Holt, Steven J. Jones, Elodie Portales-Casamar, Wyeth W. Wasserman, Vikramjit Chopra
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Patent number: 9178096Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.Type: GrantFiled: October 15, 2014Date of Patent: November 3, 2015Assignee: Leidos, Inc.Inventors: John Paul Ziegler, Howard Walter Walker, Richard Holmes Griffey, Newell Convers Wyeth
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Patent number: 9162753Abstract: An unmanned aerial vehicle and associated methods for inspecting infrastructure assets includes a multirotor, electrically driven helicopter apparatus and power supply; a flight computer; positioning and collision avoidance equipment; and at least one sensor such as a camera. The flight computer is programmed for automated travel to and inspection of selected waypoints, at which condition data is collected for further analysis. The method also includes protocols for segmenting the flight path to accomplish sequential inspection of a linear asset such as a power line using limited-range equipment.Type: GrantFiled: December 31, 2013Date of Patent: October 20, 2015Assignee: Southern Electrical Equipment Company, Inc.Inventors: Andrew S. Panto, Barry Wyeth Thomas, Barry Craig Thomas
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Publication number: 20150287864Abstract: A stacked luminescent solar concentrator includes two separate absorption/emission cells, each having a layer of luminophore-type material, wherein a top layer is a high band gap layer comprised of quantum dots in polymer, wherein the quantum dots are engineered so as to absorb a significant percentage of photons above bandgap. The bottom layer is a lower band gap layer comprised of quantum dots in polymer, wherein the quantum dots in the second layer are engineered so as to absorb photons not absorbed in the top layer, thus increasing total percentage of absorbed photons. Photovoltaic cells are located below the layers at the bottom of the cells or at the edges of the cells. The sides and lower surfaces of the cells may include reflective surfaces as discussed further herein. Reflection losses from the top surface thereof may be minimized using a broadband anti-reflective coating (AR) on the surface.Type: ApplicationFiled: October 15, 2014Publication date: October 8, 2015Inventors: John Paul Ziegler, Howard Walter Walker, Richard Holmes Griffey, Newell Convers Wyeth
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Publication number: 20150259691Abstract: Isolated polynucleotides comprising a UGT8 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: March 11, 2015Publication date: September 17, 2015Inventors: Elizabeth M. Simpson, Cletus D'Souza, Charles de Leeuw, Daniel Goldowitz, Robert A. Holt, Elodie Portales-Casamar, Vikramjit Chopra, Wyeth W. Wasserman, Steven J. Jones
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Publication number: 20150240259Abstract: Isolated polynucleotides comprising a PCP2 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: March 3, 2015Publication date: August 27, 2015Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra, Charles de Leeuw
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Publication number: 20150223722Abstract: A diagnostic method for monitoring changes in a fluid medium in a patient's head. The method includes positioning a transmitter at a first location on or near the patient's head, the transmitter generates and transmits a time-varying magnetic field into a fluid medium in the patient's head responsive to a first signal; positioning a receiver at a second location on or near the patient's head offset from the transmitter, the receiver generates a second signal responsive to a received magnetic field at the receiver; transmitting a time-varying magnetic field into the fluid medium in the patient's head in response to the first signal; receiving the transmitted magnetic field; generating the second signal responsive to the received magnetic field; and determining, a phase shift between the transmitted magnetic field and the received magnetic field for a plurality of frequencies of the transmitted time-varying magnetic field.Type: ApplicationFiled: April 20, 2015Publication date: August 13, 2015Inventors: Richard Warren WYETH, Mitchell Elliott LEVINSON
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Patent number: 9074222Abstract: Isolated polynucleotides comprising a DCX mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: GrantFiled: January 23, 2014Date of Patent: July 7, 2015Assignee: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra, Charles de Leeuw
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Publication number: 20150166635Abstract: Isolated polynucleotides comprising a GPR88 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, antisense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: September 16, 2014Publication date: June 18, 2015Inventors: Elizabeth M. Simpson, Charles de Leeuw, Wyeth W. Wasserman, Elodie Portales-Casamar, Steven J. Jones, Cletus D'Souza, Robert A. Holt, Vikramjit Chopra, Daniel Goldowitz
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Patent number: 9006413Abstract: Isolated polynucleotides comprising a PCP2 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: GrantFiled: November 21, 2013Date of Patent: April 14, 2015Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra, Charles de Leeuw
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Publication number: 20150024498Abstract: Isolated polynucleotides comprising a CLDN5 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The mini-promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc.Type: ApplicationFiled: February 13, 2014Publication date: January 22, 2015Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Daniel Goldowitz, Charles de Leeuw
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Publication number: 20150010518Abstract: Isolated polynucleotides comprising a NR2E1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, gene therapy, etc.Type: ApplicationFiled: June 30, 2014Publication date: January 8, 2015Inventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Daniel Goldowitz, Charles de Leeuw
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Publication number: 20150005699Abstract: An automated peritoneal dialysis system provides various features including prescription-driven dialysis fluid preparation, an integrated disposable fluid circuit, and sensor capabilities that allow accurate filing and draining control with high safety margins. Features include a peritoneal fluid circuit with a pressure sensor at either end and methods and devices for using the pressure signals. Other features and embodiments are disclosed.Type: ApplicationFiled: September 23, 2012Publication date: January 1, 2015Applicant: NxStage Medical, Inc.Inventors: Jeffrey H. Burbank, James M. Brugger, Dennis M. Treu, Mark T. Wyeth
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Patent number: 8895715Abstract: Isolated polynucleotides comprising an S100B promoter are provided, where an S100B regulatory element is operably joined to an S100B basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of an expression vector is provided, which may be integrated in the genome of the cell. The promoter may also be provided in a vector, for example in combination with an expressible sequence. The polynucleotides find use in a method of expressing a sequence of interest, e.g. for identifying or labeling cells, monitoring or tracking the expression of cells, etc.Type: GrantFiled: May 7, 2009Date of Patent: November 25, 2014Assignee: The University of British ColumbiaInventors: Elizabeth M. Simpson, Wyeth W. Wasserman, Robert A. Holt, Steven J. Jones, Daniel Goldowitz, Elodie Portales-Casamar, Cletus D'Souza, Vikramjit Chopra