Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: A treatment apparatus for applying combinations of thermal and compressive treatment programmes to a human or animal body comprises a brace 1110 which itself comprises first and second brace portions 1120, 1130 connected by webbing/strapping 1140. The strapping 1140 comprises first and second straps 1150, 1160, each of which engages both of the brace portions 1120, 1130 via a loop 1170a on one of the brace portions and is held by an anchor 1170b on the other brace portion. The brace portions each comprise a rigid outer shell 1180 of moulded plastics material, and each includes a mounting socket 1190 for detachably mounting a thermal treatment unit (not shown). The mounting sockets 1190 include apertures 200 that extend through the brace portions to the patient facing side, so as to present an active face of the treatment unit to the treatment site.

Abstract: Provided is a small sized, portable monitoring device capable of determining an analyte under investigation and having a system and method for providing compliance information to a user of his management of a disease, and for easily navigating a menu structure by means of manual control(s). Further provided is the provision of feedback to the user in form of a disease management information to be easily understood by a user such as the further described COMPLIANCE WINDOW or the INDICATOR CATEGORIES. The user interface can be used in connection with a glucose diagnostic device, a coagulation diagnostic device, immunoassay diagnostic device, and other monitoring devices such as an blood pressure monitor or a pedometer.

Abstract: A container for moisture sensitive test elements comprising a container body (2, 102, 202), an insert (22, 122, 220) fitting in container body, whereby a cavity (18, 118) is created between outer surface of insert wall (24, 124, 240) and inner surface of container body wall (4, 104, 204), and a lid (50, 150, 250) dimensioned to seal container open end when in a closed position, wherein a desiccant material is contained within the cavity (18, 118) between container body wall and insert wall. Insert wall defines a hollow channel (29, 129, 229) which is dimensioned that at least one test element ex-tents from the insert channel facilitating accessibility to an individual test element for the testing of an analyte of interest. Desiccant material includes an indicator whose colour changes when exposed to moisture indicating to a user whether contents therein, i.e. test elements, have been compromised by environmental factors.

Abstract: An analyte test element for the qualitative and/or quantitative determination of at least one analyte in a physiological or aqueous sample fluid having a first surface (2a) and a second surface (4a) in a predetermined distance opposite from each other, said both surfaces are provided with two substantially equivalent patterns forming areas of high and low surface energy which are aligned mostly congruent, whereby the areas of high surface energy (6, 6?) create a sample distribution system with at least two detection areas (6a, 6?a), said at least one of the detection areas (6a, 6?a) of the first and second surfaces (2a, 4a) is provided with at least one non-enzymatic recognition element (32).

Abstract: Methods for the production of new Adonis palaestina plants and plant populations with improved characteristics such as increased flower size, astaxanthin content, and/or reduced cardenolide content are provided. Also provided are an astaxanthin-containing Adonis oleoresin and methods of extracting astaxanthin and other ketocarotenoids from flowers of Adonis palaestina plants, while reducing non-ketocarotenoids and cardenolides.

Abstract: A test element for the determination of coagulation in a plasma or whole blood sample having a first surface (2a) and a second surface (4a) in a predetermined distance opposite from each other, said both surfaces being provided with two substantially equivalent patterns forming areas of high and low surface energy which are aligned mostly congruent, whereby the areas of high surface energy create a sample distribution system (6) with at least one detection area (6a), wherein the detection area(s) (6a, 6?a) of the first and second surfaces (2a, 4a) is/are provided with at least one coagulation stimulation reagent. The coagulation test element is provided with an integrated quality control system suitable for dry reagent test strip format with a very small sample volume of about 0.5 ?L. The production of the inventive coagulation test element involves only a small number of uncomplicated production steps enabling an inexpensive production of the element.

Abstract: A synchronization technique is described which finds use in a disk array subsystem comprising a plurality of disk storage devices connected to a controller. In response to signals from each of the devices specifying their angular position at a particular time, the controller calculates the relative angular positions of the devices and issues a signal to each of the devices specifying the amount and direction of chance in rotational velocity required to achieve synchronization. In a two device subsystem, the signal to one device will specify a speed decrease and the signal to the second device will specify a speed increase.

Abstract: A synchronization technique is described which finds use in a disk array subsystem comprising a plurality of disk storage devices connected to a controller. In response to signals from each of the devices specifying their angular position at a particular time, the controller calculates the relative angular positions of the devices and issues a signal to each of the devices specifying the amount and direction of change in rotational velocity required to achieve synchronization. In a two device subsystem, the signal to one device will specify a speed decrease and the signal to the second device will specify a speed increase.

Abstract: This specification describes an associative memory cell capable of performing logic functions. The cell comprises two transistors with their collectors connected to an output line and their emitters connected to an input line carrying either the true or complement of one variable. The bases of the two transistors can each be selectively connected to either the true and complement of a second variable or fixed at one of two reference or logic levels to permit the performing of sixteen different logic functions of the two input variables by the cell.