Patents by Inventor Wyndham W. Lathem

Wyndham W. Lathem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of reducing the viscosity of mucus
    Patent number: 7704718
    Abstract: Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933 and other E. coli that binds to and cleaves C1-esterase inhibitor, and antibodies specific for the polypeptide. Also disclosed are methods employing the polypeptide for diagnosing enterohemorrhagic E. coli infection, identifying potential inhibitors of its activity, and reducing viscosity of material containing glycosylated polypeptides.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: April 27, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Rodney A. Welch, Wyndham W. Lathem, Thomas E. Grys, Laura Walters
  • METHOD OF REDUCING THE VISCOSITY OF MUCUS
    Publication number: 20090306344
    Abstract: Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933 and other E. coli that binds to and cleaves C1-esterase inhibitor, and antibodies specific for the polypeptide. Also disclosed are methods employing the polypeptide for diagnosing enterohemorrhagic E. coli infection, identifying potential inhibitors of its activity, and reducing viscosity of material containing glycosylated polypeptides.
    Type: Application
    Filed: August 30, 2007
    Publication date: December 10, 2009
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Rodney A. Welch, Wyndham W. Lathem, Thomas E. Grys, Laura Walters
  • METHODS OF TREATING PNEUMONIC PLAGUE
    Publication number: 20080214682
    Abstract: The present invention relates to methods of treating pneumonic plague. More specifically, the present invention relates to methods of using plasmin or Pla inhibitors to treat pneumonic plague.
    Type: Application
    Filed: December 21, 2007
    Publication date: September 4, 2008
    Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: Wyndham W. Lathem, Virginia Miller, William E. Goldman
  • Method of reducing complement - mediated disruption of cells
    Patent number: 7264922
    Abstract: Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933 and other E. coli that binds to and cleaves C1-esterase inhibitor, and antibodies specific for the polypeptide. Also disclosed are methods employing the polypeptide for diagnosing enterohemorrhagic E. coli infection, identifying potential inhibitors of its activity, and reducing viscosity of material containing glycosylated polypeptides.
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: September 4, 2007
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Rodney A. Welch, Wyndham W. Lathem, Thomas E. Grys
  • O157:H7 C1-INH-binding protein and methods of use
    Patent number: 7214479
    Abstract: Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933 and other E. coli that binds to and cleaves C1-esterase inhibitor, and antibodies specific for the polypeptide. Also disclosed are methods employing the polypeptide for diagnosing enterohemorrhagic E. coli infection, identifying potential inhibitors of its activity, and reducing viscosity of material containing glycosylated polypeptides.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: May 8, 2007
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Rodney A. Welch, Wyndham W. Lathem, Thomas E. Grys
  • E. coli O157:H7 C1 esterase inhibitor-binding protein and methods of use
    Patent number: 6872559
    Abstract: Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933and other enterohemorrhagic E. coli that binds to and cleaves C1-esterase inhibitor. Also disclosed are methods employing the polypeptide for diagnosing and treating colitis or hemolytic uremic syndrome, and methods of detecting potential therapeutics.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: March 29, 2005
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Rodney A. Welch, Wyndham W. Lathem
  • E.coli O157:H7 C1-INH-binding protein and methods of use
    Publication number: 20040234530
    Abstract: Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933 and other E. coli that binds to and cleaves C1-esterase inhibitor, and antibodies specific for the polypeptide. Also disclosed are methods employing the polypeptide for diagnosing enterohemorrhagic E. coli infection, identifying potential inhibitors of its activity, and reducing viscosity of material containing glycosylated polypeptides.
    Type: Application
    Filed: February 25, 2004
    Publication date: November 25, 2004
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Rodney A. Welch, Wyndham W. Lathem, Thomas E. Grys
  • E. coli O157:H7 C1 esterase inhibitor-binding protein and methods of use
    Publication number: 20020160433
    Abstract: Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933 and other enterohemorrhagic E. coli that binds to and cleaves C1-esterase inhibitor. Also disclosed are methods employing the polypeptide for diagnosing and treating colitis or hemolytic uremic syndrome, and methods of detecting potential therapeutics.
    Type: Application
    Filed: October 26, 2001
    Publication date: October 31, 2002
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Rodney A. Welch, Wyndham W. Lathem