Abstract: A gateway device is enabled to initiate sending of push notifications to an associated device. The push notifications can be sent even when a gateway device related application is not running on the device. The push notifications can also be sent to the device whenever it has internet connectivity, even if the internet connectivity is not being provided by the gateway device hotspot. In an embodiment, a mobile access gateway system can receive a notification from the gateway device that is directed to another device. The mobile access gateway system can determine whether or not the gateway device and the other device are related to each other and then instruct a push notification server to send the device a push notification.

Abstract: A gateway device is enabled to initiate sending of push notifications to an associated device. The push notifications can be sent even when a gateway device related application is not running on the device. The push notifications can also be sent to the device whenever it has internet connectivity, even if the internet connectivity is not being provided by the gateway device hotspot. In an embodiment, a mobile access gateway system can receive a notification from the gateway device that is directed to another device. The mobile access gateway system can determine whether or not the gateway device and the other device are related to each other and then instruct a push notification server to send the device a push notification.

Abstract: A gateway device is enabled to initiate sending of push notifications to an associated device. The push notifications can be sent even when a gateway device related application is not running on the device. The push notifications can also be sent to the device whenever it has internet connectivity, even if the internet connectivity is not being provided by the gateway device hotspot. In an embodiment, a mobile access gateway system can receive a notification from the gateway device that is directed to another device. The mobile access gateway system can determine whether or not the gateway device and the other device are related to each other and then instruct a push notification server to send the device a push notification.

Abstract: A gateway device is enabled to initiate sending of push notifications to an associated device. The push notifications can be sent even when a gateway device related application is not running on the device. The push notifications can also be sent to the device whenever it has internet connectivity, even if the internet connectivity is not being provided by the gateway device hotspot. In an embodiment, a mobile access gateway system can receive a notification from the gateway device that is directed to another device. The mobile access gateway system can determine whether or not the gateway device and the other device are related to each other and then instruct a push notification server to send the device a push notification.

Abstract: The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, and ribozymes, that modulate lymphocyte activation via modulation of PAK2; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.

Abstract: The invention relates to methods and compositions useful for screening for altered cellular phenotypes using an inducible expression system to enrich for and detect the altered phenotypes and, more particularly, relates to screening libraries of candidate bioactive agents, for example, nucleic acids and peptides, in cells using an regulatable expression system to enrich for a subpopulation of cells having an altered phenotype due to the presence of a candidate bioactive agent.

Abstract: The present invention provides compositions and methods for modulating lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to lymphocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating lymphocyte activation.

Abstract: The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding the nucleic acids and proteins listed in FIG. 7, which are involved in modulation of lymphocyte activation and migration, e.g., A-raf-1, Lck, Zap70, Syk, PLC?1, PAG, SHP/PTP1C, CSK, nucleolin, SLAP, PAK2, TRAC1, TCPTP/PTPN2, EDG1, IL10-R?, integrin?2, Enolase 1a, PRSM1, CLN2, P2X5b, 6PFKL, DUSP1, KIAA0251, GG2-1, GRB7, SH2-B, STAT1, TCF19, HFP101S, RERE, SudD, Ku70, SCAMP2, Fibulin-5, KIAA1228, Est from clone 2108068, vimentin, filamin A ?, centractin ?, moesin, TIMP3, and RNH.

Abstract: An intraocular lens for use in a mammalian eye includes an optic adapted to focus light toward a retina of the mammalian eye and, in cooperation with the mammalian eye, to provide accommodation, the optic including a first portion adapted to move in response to the action of the mammalian eye; and a second portion surrounded by the first portion, and having a higher index of refraction than the first portion and/or being less deformable than the first portion in response to forces exerted by the mammalian eye.

Abstract: An intraocular lens (IOL) for use in a mammalian eye includes an optic adapted to focus light toward a retina of the mammalian eye and, in cooperation with the mammalian eye, to provide accommodation, the optic including a first portion adapted to move in response to the action of the mammalian eye; and a second portion secured to the first portion and having a higher index of refraction than the first portion and/or being positioned generally anterior of the first portion.

Abstract: The present invention provides compositions and methods for modulating leukocyte and/or platelet activation. Nucleic acids and proteins which are capable of modulating leukocyte and/or platelet activation are provided. Compositions and methods for the treatment of disorders related to leukocyte and/or platelet activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte and/or platelet activation.