Patents by Inventor X. Long Zheng

X. Long Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human monoclonal autoantibodies to ADAMTS13 and uses thereof
    Patent number: 11597778
    Abstract: The present invention relates to compositions and methods of use of anti-ADAMTS13 autoantibodies and fragments thereof. In one aspect, the invention includes a composition comprising an isolated anti-ADAMTS13 autoantibody or fragment thereof. In other aspects, methods are described for generating an in vivo model of thrombotic thrombocytopenic purpura (TTP) comprising introducing at least one anti-ADAMTS13 autoantibody or fragment thereof into a model organism and identifying an anti-autoimmune reagent for treating TTP.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: March 7, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Donald L. Siegel, Stephen Kacir, Eric Ostertag, X. Long Zheng
  • HUMAN MONOCLONAL AUTOANTIBODIES TO ADAMTS13 AND USES THEREOF
    Publication number: 20190031771
    Abstract: The present invention relates to compositions and methods of use of anti-ADAMTS13 autoantibodies and fragments thereof. In one aspect, the invention includes a composition comprising an isolated anti-ADAMTS13 autoantibody or fragment thereof. In other aspects, methods are described for generating an in vivo model of thrombotic thrombocytopenic purpura (TTP) comprising introducing at least one anti-ADAMTS13 autoantibody or fragment thereof into a model organism and identifying an anti-autoimmune reagent for treating TTP.
    Type: Application
    Filed: April 6, 2016
    Publication date: January 31, 2019
    Inventors: Donald L. SIEGEL, Stephen KACIR, Eric OSTERTAG, X. Long ZHENG
  • Gain-of-function ADAMTS13 variants resistant to auto antibody inhibition and methods of use thereof
    Patent number: 9546360
    Abstract: Compositions and methods for the treatment of thrombotic thrombocytopenic purpura are disclosed.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: January 17, 2017
    Assignee: The Children's Hospital of Philadelphia
    Inventor: X. Long Zheng
  • Gain-of-Function ADAMTS13 Variants Resistant to Auto Antibody Inhibition and Methods of Use Thereof
    Publication number: 20150044171
    Abstract: Compositions and methods for the treatment of thrombotic thrombocytopenic purpura are disclosed.
    Type: Application
    Filed: June 23, 2014
    Publication date: February 12, 2015
    Inventor: X. Long Zheng
  • Compositions and Methods for Modulation of ADAMTS13 Activity
    Publication number: 20100144634
    Abstract: Compositions and methods are provided for the diagnosis and treatment of thrombotic thrombocytopenic purpura (TTP), stroke and myocardial infarction.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 10, 2010
    Inventors: X. Long Zheng, Ping Zhang, Sriram Krishnaswarny, Wenjing Cao