Patents by Inventor X. Michael Liu

X. Michael Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11414501
    Abstract: The present invention relates to a method of and an apparatus for extending the shelf life of an initiated monomer mixture, the method comprising the prevention of premature free radical polymerisation by introducing oxygen or oxygen-containing gas into a container of the initiated monomer mixture and providing mechanical agitation to the container, wherein said introduction and agitation are performed in a temperature and pressure controlled environment.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 16, 2022
    Assignee: Bausch & Lomb Incorporated
    Inventors: Sean Lyons, Joseph Dowling, John Flynn, X. Michael Liu, E. Peter Maziarz
  • Patent number: 9943622
    Abstract: Method for minimizing the sorption of tear lipids on frequent replacement, or extended-wear, contact lenses, the method comprising (a) contacting the contact lens selected from the group consisting of senofilcon A, lotrafilcon A, lotrafilcon B, and comfilcon A B with a lens care solution for a period of at least three hours to minimize the accumulation of tear lipids on the contact lens. The lens care solution comprises 0.5 ppm to 10 ppm ?-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-?-tris(2-hydroxyethyl) ammonium chloride; citrate, citric acid or a mixture thereof; and 0.005 wt. % to 0.05 wt. % hyaluronic acid. The method also includes (b) inserting the soaked contact lens into one's eye, and (c) repeating steps (a) and (b).
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: April 17, 2018
    Assignee: Bausch & Lomb Incorporated
    Inventors: X. Michael Liu, Joseph A. Chinn, George L. Grobe, III, E. Peter Maziarz
  • Publication number: 20160022860
    Abstract: Method for minimizing the sorption of tear lipids on frequent replacement, or extended-wear, contact lenses, the method comprising (a) contacting the contact lens selected from the group consisting of senofilcon A, lotrafilcon A, lotrafilcon B, and comfilcon A B with a lens care solution for a period of at least three hours to minimize the accumulation of tear lipids on the contact lens. The lens care solution comprises 0.5 ppm to 10 ppm ?-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-?-tris(2-hydroxyethyl) ammonium chloride; citrate, citric acid or a mixture thereof; and 0.005 wt. % to 0.05 wt. % hyaluronic acid. The method also includes (b) inserting the soaked contact lens into one's eye, and (c) repeating steps (a) and (b).
    Type: Application
    Filed: September 24, 2013
    Publication date: January 28, 2016
    Applicant: Bausch & Lomb Incorporated
    Inventors: X. Michael Liu, Joseph A. Chinn, George L. Grobe, E. Peter Maziarz
  • Publication number: 20160017064
    Abstract: The present invention relates to a method of and an apparatus for extending the shelf life of an initiated monomer mixture, the method comprising the prevention of premature free radical polymerisation by introducing oxygen or oxygen-containing gas into a container of the initiated monomer mixture and providing mechanical agitation to the container, wherein said introduction and agitation are performed in a temperature and pressure controlled environment.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 21, 2016
    Inventors: Sean LYONS, Joseph DOWLING, John FLYNN, X. Michael LIU, E. Peter MAZIARZ
  • Patent number: 8530641
    Abstract: Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 ?m or less to provide a sterilized high salt, hyaluronic acid solution.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: September 10, 2013
    Assignee: Bausch & Lomb Incorporated
    Inventors: X. Michael Liu, David J. Heiler, Thomas Menzel, Abbie Brongo, Susan E. Burke, Karl Cummins
  • Publication number: 20120295869
    Abstract: Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 ?m or less to provide a sterilized high salt, hyaluronic acid solution.
    Type: Application
    Filed: August 1, 2012
    Publication date: November 22, 2012
    Inventors: X. Michael Liu, David J. Heiler, Thomas Menzel, Abbie Brongo, Susan E. Burke, Karl Cummins
  • Patent number: 8283463
    Abstract: A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: October 9, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventors: X. Michael Liu, David J. Heiler, Thomas Menzel, Abbie Brongo, Susan E. Burke, Karl Cummins
  • Publication number: 20120122815
    Abstract: The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
    Type: Application
    Filed: January 11, 2012
    Publication date: May 17, 2012
    Inventors: Erning Xia, Joseph C. Salamone, X. Michael Liu
  • Patent number: 8114420
    Abstract: The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: February 14, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventors: Erning Xia, Joseph Salamone, X. Michael Liu
  • Publication number: 20110301250
    Abstract: The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
    Type: Application
    Filed: August 22, 2011
    Publication date: December 8, 2011
    Inventors: Erning Xia, Joseph Salamone, X. Michael Liu
  • Publication number: 20110195925
    Abstract: A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
    Type: Application
    Filed: February 9, 2010
    Publication date: August 11, 2011
    Inventors: X. Michael Liu, David J. Heiler, Thomas Menzel, Abbie Brongo, Susan E. Burke, Karl Cummins
  • Publication number: 20100106128
    Abstract: Contact lens cases for delivering ophthalmic active agents to contact lenses. A contact lens case includes a container defining a reservoir for soaking a contact lens in a solution, and a lid assembly that may be secured to the container for closing the reservoir. The lid assembly includes a lid and a dispenser pack. The dispenser pack includes one or more compartments containing a treatment unit which may be dispensed from the compartment(s) into the solution. After the contact lens soaks in solution and retains or absorbs a suitable amount of the ophthalmic agent from the treatment unit, the contact lens is inserted in a user's eye for treating the eye.
    Type: Application
    Filed: October 23, 2008
    Publication date: April 29, 2010
    Inventors: Shane Mao, Joseph Barr, X. Michael Liu, Suzanne F. Groemminger
  • Publication number: 20100086514
    Abstract: A contact lens care solution comprising: a cationic antimicrobial component having an average molecular weight (MNA), and a cationic oligomer or nitrogen/amine oligomer having a number average molecular weight (MNO) from 500 daltons to 15,000 daltons. The lens care solutions are used to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.
    Type: Application
    Filed: October 1, 2009
    Publication date: April 8, 2010
    Inventors: X. Michael Liu, David J. Heiler
  • Patent number: D616198
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: May 25, 2010
    Assignee: Bausch & Lomb Incorporated
    Inventors: X. Michael Liu, Heidi A. Chapman