Patents by Inventor Xander Frank Van Kooten
Xander Frank Van Kooten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11364499Abstract: Devices for detecting a molecule of interest comprising an electrokinetic focusing apparatus and a nanopore apparatus are provided. Kits and systems comprising the apparatus are also provided; as are methods of detecting molecules of interest comprising running the molecules through the electrokinetic focusing apparatus and then detecting the focused molecules as they pass through the nanopore.Type: GrantFiled: May 15, 2018Date of Patent: June 21, 2022Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITEDInventors: Amit Meller, Moran Bercovici, Xander Frank Van Kooten, Joshua Spitzberg
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Patent number: 11119068Abstract: The present invention provides, in some embodiments, an isotachophoresis (ITP) apparatus, a kit comprising same and method of use thereof for the focusing analytes of interest from large sample volumes.Type: GrantFiled: October 3, 2017Date of Patent: September 14, 2021Assignees: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Moran Bercovici, Govind Kaigala, Xander Frank Van Kooten, Nadya Ostromohov, Federico Paratore
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Patent number: 10926258Abstract: Microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers. The microfluidic probe head includes: an inlet, an outlet, a first fluid channel and a second fluid channel and a fluid bypass connecting the first fluid channel and the second fluid channel. The first fluid channel delivers the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass allows the spacers to be removed from the first fluid channel obtaining a free sequence of separate liquid volumes without spacers, the first fluid channel delivers the free sequence of separate liquid volumes to the deposition area, and the second fluid channel delivers the removed spacers from the fluid bypass to the outlet. The present invention also provides a microfluidic probe and method for processing a sequence of separate liquid volumes.Type: GrantFiled: March 30, 2020Date of Patent: February 23, 2021Assignee: International Business Machines CorporationInventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Xander Frank Van Kooten
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Publication number: 20200230599Abstract: Microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers. The microfluidic probe head includes: an inlet, an outlet, a first fluid channel and a second fluid channel and a fluid bypass connecting the first fluid channel and the second fluid channel. The first fluid channel delivers the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass allows the spacers to be removed from the first fluid channel obtaining a free sequence of separate liquid volumes without spacers, the first fluid channel delivers the free sequence of separate liquid volumes to the deposition area, and the second fluid channel delivers the removed spacers from the fluid bypass to the outlet. The present invention also provides a microfluidic probe and method for processing a sequence of separate liquid volumes.Type: ApplicationFiled: March 30, 2020Publication date: July 23, 2020Inventors: JULIEN AUTEBERT, EMMANUEL DELAMARCHE, GOVIND KAIGALA, XANDER FRANK VAN KOOTEN
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Publication number: 20200171489Abstract: Devices for detecting a molecule of interest comprising an electrokinetic focusing apparatus and a nanopore apparatus are provided. Kits and systems comprising the apparatus are also provided; as are methods of detecting molecules of interest comprising running the molecules through the electrokinetic focusing apparatus and then detecting the focused molecules as they pass through the nanopore.Type: ApplicationFiled: May 15, 2018Publication date: June 4, 2020Inventors: Amit MELLER, Moran BERCOVICI, Xander Frank VAN KOOTEN, Joshua SPITZBERG
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Patent number: 10639631Abstract: Microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers. The microfluidic probe head includes: an inlet, an outlet, a first fluid channel and a second fluid channel and a fluid bypass connecting the first fluid channel and the second fluid channel. The first fluid channel delivers the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass allows the spacers to be removed from the first fluid channel obtaining a free sequence of separate liquid volumes without spacers, the first fluid channel delivers the free sequence of separate liquid volumes to the deposition area, and the second fluid channel delivers the removed spacers from the fluid bypass to the outlet. The present invention also provides a microfluidic probe and method for processing a sequence of separate liquid volumes.Type: GrantFiled: February 11, 2016Date of Patent: May 5, 2020Assignee: International Business Machines CorporationInventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Xander Frank Van Kooten
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Patent number: 10549276Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.Type: GrantFiled: July 23, 2019Date of Patent: February 4, 2020Assignee: International Business Machines CorporationInventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
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Publication number: 20190344268Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.Type: ApplicationFiled: July 23, 2019Publication date: November 14, 2019Inventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
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Publication number: 20190310227Abstract: The present invention provides, in some embodiments, an isotachophoresis (ITP) apparatus, a kit comprising same and method of use thereof for the focusing analytes of interest from large sample volumes.Type: ApplicationFiled: October 3, 2017Publication date: October 10, 2019Inventors: Moran BERCOVICI, Govind KAIGALA, Xander Frank VAN KOOTEN, Nadya OSTROMOHOV, Federico PARATORE
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Patent number: 10391488Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.Type: GrantFiled: February 11, 2016Date of Patent: August 27, 2019Assignee: International Business Machines CorporationInventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten
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Patent number: 10357770Abstract: A microfluidic probe is disclosed. The microfluidic probe includes a probe head, a liquid spacer supply and a spacer modulation unit. The probe head may include a processing liquid channel in fluid communication with a processing liquid aperture provided on a face of the probe head. The probe head is configured to transport, circulate, recirculate, or move some processing liquid in (or via) the processing liquid channel toward and/or from the processing liquid aperture. The spacer supply is fluidly connected, via a spacer insertion junction, to the processing liquid channel. The spacer supply is configured for inserting liquid spacers into the processing liquid channel, via the spacer insertion junction. Liquid volumes can be obtained, which are separated by inserted liquid spacers. The spacer modulation unit is configured to control the spacer supply, to modulate the insertion of spacers via the spacer supply. Related devices and methods of operation are disclosed.Type: GrantFiled: October 9, 2015Date of Patent: July 23, 2019Assignee: International Business Machines CorporationInventors: Julien Autebert, Julien Cors, Emmanuel Delamarche, Govind Kaigala, Xander Frank Van Kooten
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Publication number: 20170100717Abstract: A microfluidic probe is disclosed. The microfluidic probe includes a probe head, a liquid spacer supply and a spacer modulation unit. The probe head may include a processing liquid channel in fluid communication with a processing liquid aperture provided on a face of the probe head. The probe head is configured to transport, circulate, recirculate, or move some processing liquid in (or via) the processing liquid channel toward and/or from the processing liquid aperture. The spacer supply is fluidly connected, via a spacer insertion junction, to the processing liquid channel. The spacer supply is configured for inserting liquid spacers into the processing liquid channel, via the spacer insertion junction. Liquid volumes can be obtained, which are separated by inserted liquid spacers. The spacer modulation unit is configured to control the spacer supply, to modulate the insertion of spacers via the spacer supply. Related devices and methods of operation are disclosed.Type: ApplicationFiled: October 9, 2015Publication date: April 13, 2017Inventors: Julien AUTEBERT, Julien CORS, Emmanuel DELAMARCHE, Govind KAIGALA, Xander Frank VAN KOOTEN
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Publication number: 20160243549Abstract: Microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers. The microfluidic probe head includes: an inlet, an outlet, a first fluid channel and a second fluid channel and a fluid bypass connecting the first fluid channel and the second fluid channel. The first fluid channel delivers the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass allows the spacers to be removed from the first fluid channel obtaining a free sequence of separate liquid volumes without spacers, the first fluid channel delivers the free sequence of separate liquid volumes to the deposition area, and the second fluid channel delivers the removed spacers from the fluid bypass to the outlet. The present invention also provides a microfluidic probe and method for processing a sequence of separate liquid volumes.Type: ApplicationFiled: February 11, 2016Publication date: August 25, 2016Inventors: JULIEN AUTEBERT, EMMANUEL DELAMARCHE, GOVIND KAIGALA, XANDER FRANK VAN KOOTEN
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Publication number: 20160236194Abstract: A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes including a respective target substance associated with a respective target area, the microfluidic probe head including an inlet and an outlet; a first fluid channel fluidly connected to the inlet, the first fluid channel configured for delivering an injection liquid from the inlet to a respective target area; a second fluid channel fluidly connected to the outlet, the second fluid channel configured for delivering liquid volumes from the respective target area to the outlet; and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit configured for inserting spacers into the second fluid channel between the liquid volumes to provide the sequence of separate liquid volumes separated by spacers.Type: ApplicationFiled: February 11, 2016Publication date: August 18, 2016Inventors: Julien Autebert, Emmanuel Delamarche, Govind Kaigala, Aditya Kashyap, Xander Frank Van Kooten