Patents by Inventor Xanthe M. Lam

Xanthe M. Lam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein formulation
    Publication number: 20010014326
    Abstract: A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
    Type: Application
    Filed: March 14, 2001
    Publication date: August 16, 2001
    Applicant: Genentech, Inc.
    Inventors: James Andya, Jeffrey L. Cleland, Chung C. Hsu, Xanthe M. Lam, David E. Overcashier, Steven J. Shire, Janet Yu-Feng Yang, Sylvia Sau-Yan Wu
  • Protein formulation
    Patent number: 6267958
    Abstract: A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
    Type: Grant
    Filed: March 14, 1996
    Date of Patent: July 31, 2001
    Assignee: Genentech, Inc.
    Inventors: James Andya, Jeffrey L. Cleland, Chung C. Hsu, Xanthe M. Lam, David E. Overcashier, Steven J. Shire, Janet Yu-Feng Yang, Sylvia Sau-Yan Wu
  • Antibody formulation
    Patent number: 6171586
    Abstract: A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody not subjected to prior lyophilization, a buffer maintaining the pH in the range from about 4.5 to about 6.0, a surfactant and a polyol is described, along with uses for such a formulation.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: January 9, 2001
    Assignee: Genentech, Inc.
    Inventors: Xanthe M. Lam, James Q. Oeswein, Boonsri Ongpipattanakul, Zahra Shahrokh, Sharon X. Wang, Robert P. Weissburg, Rita L. Wong
  • Controlled release microencapsulated NGF formulation
    Patent number: 6113947
    Abstract: NGF microencapsulation compositions having controlled release characteristics, preferably with increased stability, for the NGF component, particularly human recombinant NGF ("rhNGF") are provided that yield enhanced stability of NGF for use in promoting nerve cell growth, repair, survival, differentiation, maturation or function. Methods for making and using such compositions are also provided.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: September 5, 2000
    Assignee: Genentech, Inc.
    Inventors: Jeffrey L. Cleland, Xanthe M. Lam, Eileen T. Duenas
  • Stabilizing formulation for NGF
    Patent number: 6090781
    Abstract: Formulations are provided comprising NGF and acetate-containing buffer from pH 5 to 6 that provide enhanced stability of NGF for use in promoting nerve cell growth, repair, survival, differentiation, maturation or function.
    Type: Grant
    Filed: November 6, 1996
    Date of Patent: July 18, 2000
    Assignee: Genentech, Inc.
    Inventors: Linda R. DeYoung, Xanthe M. Lam, Tue H. Nguyen, Michael F. Powell