Patents by Inventor Xavier Dervillez

Xavier Dervillez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multifunctional Heteromultimeric Constructs
    Publication number: 20230130737
    Abstract: The present invention is situated in the field of multimers used for targeted therapies. More particularly, the invention relates to methods for preparing multifunctional heteromultimeric protein complexes with a defined ratio of functional components and to multifunctional heteromultimeric protein complexes for directing complement-dependent cytolysis, optionally comprising a scaffold, which display three or more different functional components present in a defined relative ratio, of which one is a tracking component.
    Type: Application
    Filed: November 2, 2022
    Publication date: April 27, 2023
    Applicants: Luxembourg Institute of Health (LIH), Université de Reims Champagne Ardenne URCA
    Inventors: Xavier Dervillez, Carole Devaux, Jacques H.M. Cohen
  • Multifunctional heteromultimeric constructs
    Patent number: 11518791
    Abstract: The present invention is situated in the field of multimers used for targeted therapies. More particularly, the invention relates to methods for preparing multifunctional heteromultimeric protein complexes with a defined ratio of functional components and to multifunctional heteromultimeric protein complexes for directing complement-dependent cytolysis, optionally comprising a scaffold, which display three or more different functional components present in a defined relative ratio, of which one is a tracking component.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: December 6, 2022
    Assignees: Luxembourg Institute of Health (LIH), Université de Reims Champagne Ardenne URCA
    Inventors: Xavier Dervillez, Carole Devaux, Jacques H. M. Cohen
  • Multifunctional Heteromultimeric Constructs
    Publication number: 20190382458
    Abstract: The present invention is situated in the field of multimers used for targeted therapies. More particularly, the invention relates to methods for preparing multifunctional heteromultimeric protein complexes with a defined ratio of functional components and to multifunctional heteromultimeric protein complexes for directing complement-dependent cytolysis, optionally comprising a scaffold, which display three or more different functional components present in a defined relative ratio, of which one is a tracking component.
    Type: Application
    Filed: May 22, 2017
    Publication date: December 19, 2019
    Applicants: Luxembourg Institute of Health (LIH), Université de Reims Champagne Ardenne URCA
    Inventors: Xavier Dervillez, Carole Devaux, Jacques H.M. Cohen
  • Protein constructs designed for targeting and lysis of cells
    Patent number: 9644033
    Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: May 9, 2017
    Assignee: Universite De Reims Champagne Ardenne
    Inventors: Jacques Henri Max Cohen, Wael Mahmoud, Marcelle Tonye Libyh, Nathalie Godin, Annelise Gimenez, Thierry Tabary, Beatrice Donvito, Daniel Baty, Xavier Dervillez
  • PROTEIN CONSTRUCTS DESIGNED FOR TARGETING AND LYSIS OF CELLS
    Publication number: 20150098943
    Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 9, 2015
    Inventors: Jacques Henri Max Cohen, Wael Mahmoud, Marcelle Tonye Libyh, Nathalie Godin, Annelise Gimenez, Thierry Tabary, Beatrice Donvito, Daniel Baty, Xavier Dervillez
  • Protein constructs designed for targeting and lysis of cells
    Patent number: 8900592
    Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.
    Type: Grant
    Filed: November 23, 2006
    Date of Patent: December 2, 2014
    Assignee: Universite de Reims Champagne Ardenne
    Inventors: Jacques Henri Max Cohen, Wael Mahmoud, Marcelle Tonye Libyh, Nathalie Godin, Annelise Gimenez, Thierry Tabary, Beatrice Donvito, Daniel Baty, Xavier Dervillez
  • Recombinant dimeric and heterodimeric proteins comprising amino acids 193 to 252 of the ? chain of the human C4BP protein
    Patent number: 7884190
    Abstract: A method for preparing recombinant dimeric proteins using a nucleic acid coding for the C-terminal fragment of the C4BP protein ? chain including amino acid residues 193 to 252 or a functional variant of the fragment, wherein the fragment enables covalent bonding of the heterologous polypeptides to which it is fused. Dimeric proteins obtained by means of the method and cells for carrying out the method are also described.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: February 8, 2011
    Assignee: Universite de Reims Champagne-Ardenne
    Inventors: Jacques Henri Max Cohen, Stéphane Oudin, Xavier Dervillez, Annelise Gimenez, Béatrice Donvito, Marcelle Tonye-Libyh
  • Use of a gene coding for the C4BP protein beta chain for producing recombinant dimeric proteins
    Publication number: 20070190615
    Abstract: A method for preparing recombinant dimeric proteins using a nucleic acid coding for the C-terminal fragment of the C4BP protein ? chain including amino acid residues 193 to 252 or a functional variant of the fragment, wherein the fragment enables covalent bonding of the heterologous polypeptides to which it is fused. Dimeric proteins obtained by means of the method and cells for carrying out the method are also described.
    Type: Application
    Filed: October 19, 2006
    Publication date: August 16, 2007
    Inventors: Jacques Cohen, Stephane Oudin, Xavier Dervillez, Annelise Gimenez, Beatrice Donvito, Marcelle Tonye-Libyh