Patents by Inventor Xavier Estivill Palleja

Xavier Estivill Palleja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human gene sequence of the down syndrome critical region of human chromosome 21, coding for a serine-threonine protein kinase (MNB), expressed in the neuronal regions affected in down syndrome
    Patent number: 6251664
    Abstract: An isolated human Down Syndrome critical region (MNB) DNA sequence having the nucleotide sequence depicted in SEQ ID NO:1; vector including the human Down Syndrome critical region (MNB) sequence; and isolated host cells containing the vector are provided.
    Type: Grant
    Filed: January 28, 1997
    Date of Patent: June 26, 2001
    Inventors: Xavier Estivill Palleja, Melanie Pritchard, Jordi Guimera Vilaro
  • Duplications of human chromosome 15q24-25 and anxiety disorders, diagnostic methods for their detection
    Patent number: 6225057
    Abstract: A method for identifying a person at risk for developing an anxiety disorder, said anxiety disorder selected from the group consisting of agoraphobia, social phobia, panic attacks, panic disorders, simple phobia, mood disorders, major depression, schizophrenia, and hypermobility syndrome associated with duplication of a region of the genomic sequence of human chromosome 15q24-25 defined by boundaries D15S925 (proximal end) and DS15S736 (distal end). The method comprises identifying the presence of duplication in the region of the genomic sequence of human chromosome 15q24-25 defined by the boundaries D15S925 (proximal end) and DS15S736 (distal end) in said person.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: May 1, 2001
    Assignee: Palleja, Zavier Estivell
    Inventors: Xavier Estivill Palleja, Monica Gratacos, Marga Nadal, Miguel Angel Pujana, Victor Volpini
  • Gene sequence of the Down syndrome critical region of human chromosome 21, identified by a new "Alu-splicing PCR" technique, coding for a proline-rich protein (DSCR1) highly expressed in foetal brain and in heart and method for characterizing it
    Patent number: 5869318
    Abstract: By means of a new molecular cloning technique designated "Alu-splicing PCR", we have isolated a new gene sequence, DSCR1, located in the 21q22.1-q22.2 region. DSCR1 displays a high expression in brain and heart, coding for a new protein with a proline-rich region and with some structural characteristics typical of a protein involved in transcription and/or in protein-protein interactions. The increase in the transient expression of DSCR1 mRNA in brains of young rats compared with the brains of adult rats suggests an important role of DSCR1 during the development of the central nervous system. The overexpression of pSCR1 may be involved in pathogenic abnormalities of mental retardation and/or heart defects in patients with Down syndrome.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: February 9, 1999
    Assignee: Xavier Estivill Palleja
    Inventors: Xavier Estivill Palleja, Juan Jose Fuentes, Melanie Pritchard