Patents by Inventor Xavier Franci
Xavier Franci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11094424Abstract: The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.Type: GrantFiled: August 29, 2019Date of Patent: August 17, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Xavier Franci, Steve Lignon, Audrey Lange
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Patent number: 10703771Abstract: The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]labelled compound on a single cassette. The invention allows one synthesizer in one hot cell to produce sequentially a plurality of batches of [18F]-labelled PET tracer in the same day. In particular, the present invention provides a novel arrangement useful for the trapping of [18F]fluoride and recovery of [18O]water.Type: GrantFiled: November 12, 2015Date of Patent: July 7, 2020Assignee: GE HEALTHCARE LIMITEDInventors: Xavier Franci, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge
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Patent number: 10662125Abstract: The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]-labelled compound on a single cassette. The invention allows one synthesizer in one hot cell to produce sequentially a plurality of batches of [18F]-labelled PET tracer in the same day. In particular, the present invention provides a novel arrangement useful for purifying two consecutive batches of a reaction mixture comprising an 18F-labelled compound.Type: GrantFiled: November 12, 2015Date of Patent: May 26, 2020Assignee: GE HEATLHCARE LIMITEDInventors: Xavier Franci, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge
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Patent number: 10625095Abstract: A pierce and fill connector cap for a vial sealed by an elastomeric septum includes a vial collar and a needle holder. The vial collar body defines a collar aperture to be positioned in overlying registry with the septum of the vial, and the needle holder includes a needle holder body providing a means for holding an elongate needle in registry with the collar aperture. The needle holder body being moveable with respect to said vial collar between a first position spaced from the vial collar and a second position proximate the vial collar, such that a needle held by the needle holder will puncture through the vial septum.Type: GrantFiled: July 17, 2017Date of Patent: April 21, 2020Assignee: GE HEALTHCARE LIMITEDInventors: Xavier Franci, Philippe Dumont, Svein-Erik Lindgaard
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Patent number: 10584078Abstract: The invention provides a new chemical process, a new cassette configuration, and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F]-labelled PET tracer in the same day.Type: GrantFiled: November 12, 2014Date of Patent: March 10, 2020Assignee: GE HEALTHCARE LIMITEDInventor: Xavier Franci
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Publication number: 20200043620Abstract: The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.Type: ApplicationFiled: August 29, 2019Publication date: February 6, 2020Inventors: Xavier FRANCI, Steve LIGNON, Audrey LANGE
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Patent number: 10525435Abstract: The present invention provides a system for the production of a radiopharmaceutical including a radiosynthesis apparatus and a disposable cassette. The system of the invention includes a device that enables a position on the cassette to be freed for inclusion of an additional reagent vial. With the system of the invention a broader range of radiochemical syntheses can be envisaged using the cassette.Type: GrantFiled: March 10, 2016Date of Patent: January 7, 2020Assignee: GE HEALTHCARE LIMITEDInventors: Xavier Franci, Philippe Dumont, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge
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Publication number: 20180008949Abstract: The present invention provides a system for the production of a radiopharmaceutical including a radiosynthesis apparatus and a disposable cassette. The system of the invention includes a device that enables a position on the cassette to be freed for inclusion of an additional reagent vial. With the system of the invention a broader range of radiochemical syntheses can be envisaged using the cassette.Type: ApplicationFiled: March 10, 2016Publication date: January 11, 2018Applicant: GE Healthcare LimitedInventors: Xavier Franci, Philippe Dumont, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge
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Publication number: 20170320901Abstract: The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]labelled compound on a single cassette. The invention allows one synthesizer in one hot cell to produce sequentially a plurality of batches of [18F]-labelled PET tracer in the same day. In particular, the present invention provides a novel arrangement useful for the trapping of [18F]fluoride and recovery of [18O]water.Type: ApplicationFiled: November 12, 2015Publication date: November 9, 2017Applicant: GE Healthcare LimitedInventors: Xavier Franci, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge
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Publication number: 20170313632Abstract: The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]-labelled compound on a single cassette. The invention allows one synthesizer in one hot cell to produce sequentially a plurality of batches of [18F]-labelled PET tracer in the same day. In particular, the present invention provides a novel arrangement useful for purifying two consecutive batches of a reaction mixture comprising an 18F-labelled compound.Type: ApplicationFiled: November 12, 2015Publication date: November 2, 2017Applicant: GE Healthcare LimitedInventors: Xavier Franci, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge
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Publication number: 20170312543Abstract: A pierce and fill connector cap for a vial sealed by an elastomeric septum includes a vial collar and a needle holder. The vial collar body defines a collar aperture to be positioned in overlying registry with the septum of the vial, and the needle holder includes a needle holder body providing a means for holding an elongate needle in registry with the collar aperture. The needle holder body being moveable with respect to said vial collar between a first position spaced from the vial collar and a second position proximate the vial collar, such that a needle held by the needle holder will puncture through the vial septum.Type: ApplicationFiled: July 17, 2017Publication date: November 2, 2017Inventors: XAVIER FRANCI, PHILIPPE DUMONT, SVEIN-ERIK LINDGAARD
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Patent number: 9707410Abstract: A pierce and fill connector cap for a vial sealed by an elastomeric septum includes a vial collar and a needle holder. The vial collar body defines a collar aperture to be positioned in overlying registry with the septum of the vial, and the needle holder includes a needle holder body providing a means for holding an elongate needle in registry with the collar aperture. The needle holder body being moveable with respect to said vial collar between a first position spaced from the vial collar and a second position proximate the vial collar, such that a needle held by the needle holder will puncture through the vial septum.Type: GrantFiled: November 1, 2011Date of Patent: July 18, 2017Assignee: General Electric CompanyInventors: Xavier Franci, Philippe Dumont, Svein-Erik Lindgaard
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Publication number: 20160260511Abstract: The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.Type: ApplicationFiled: October 17, 2014Publication date: September 8, 2016Inventors: Xavier Franci, Steve Lignon, Audrey Lange
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Publication number: 20160257622Abstract: The invention provides a new chemical process, a new cassette configuration, and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F]-labelled PET tracer in the same day.Type: ApplicationFiled: November 12, 2014Publication date: September 8, 2016Inventor: Xavier Franci
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Patent number: 9291606Abstract: A quality control (“QC”) system for PET or SPECT radiopharmaceuticals is disclosed that contains a disposable, no-leakage, self-contained QC cassette, which interfaces with the QC system. The QC system may include a shield that substantially surrounds the cassette such that the area and the cassette are both shielded. The QC cassette may contain shielding also. The QC cassette contains components for conducting one or more QC tests. These components include sensor and devices for performing various QC tests on radiopharmaceuticals. The QC system may contain a number of sub-systems and devices for supporting the QC tests. The QC system may produce a QC report containing the test results.Type: GrantFiled: August 22, 2011Date of Patent: March 22, 2016Assignee: GENERAL ELECTRIC COMPANYInventors: Ole Henrik Hansteen, Jan Borge Jakobsen, Svein-Erik Lindgaard, Xavier Franci, Line Roed, Arnfinn Andersen, Gro Johansen, Torsten Knuttel, Karina Martha Langseth
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Patent number: 8911689Abstract: An interfacing cap for a reagent storage vessel is provided. The interfacing cap comprises a partitioning element having a structure corresponding to an opening of the reagent storage vessel, a projection fitting disposed on the partitioning element, a holder element, and a puncturing element coupled to the projection fitting.Type: GrantFiled: April 13, 2011Date of Patent: December 16, 2014Assignee: General Electric CompanyInventors: Victor Donald Samper, Christian Rensch, Christoph Boeld, Xavier Franci
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Publication number: 20130337493Abstract: A quality control (“QC”) system for PET or SPECT radiopharmaceuticals is disclosed that contains a disposable, no-leakage, self-contained QC cassette, which interfaces with the QC system. The QC system may include a shield that substantially surrounds the cassette such that the area and the cassette are both shielded. The QC cassette may contain shielding also. The QC cassette contains components for conducting one or more QC tests. These components include sensor and devices for performing various QC tests on radiopharmaceuticals. The QC system may contain a number of sub-systems and devices for supporting the QC tests. The QC system may produce a QC report containing the test results.Type: ApplicationFiled: August 22, 2011Publication date: December 19, 2013Applicant: GE HEALTHCARE LIMITEDInventors: Ole Henrik Hansteen, Jan Borge Jakobsen, Svein-Erik Lindgaard, Xavier Franci, Line Roed, Arnfinn Andersen, Gro Johansen, Torsten Knuttel, Karina Martha Langseth
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Publication number: 20130225903Abstract: A pierce and fill connector cap for a vial sealed by an elastomeric septum includes a vial collar and a needle holder. The vial collar body defines a collar aperture to be positioned in overlying registry with the septum of the vial, and the needle holder includes a needle holder body providing a means for holding an elongate needle in registry with the collar aperture. The needle holder body being moveable with respect to said vial collar between a first position spaced from the vial collar and a second position proximate the vial collar, such that a needle held by the needle holder will puncture through the vial septum.Type: ApplicationFiled: November 1, 2011Publication date: August 29, 2013Applicant: GE HEALTHCARE LIMITEDInventors: Xavier Franci, Philippe Dumont, Svein-Erik Lindgaard
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Publication number: 20120184722Abstract: Disposable components for a separation and purification system include a flow cell, an end cap for a chromatography column, and a chromatography column useful for medium-pressure liquid chromatography (MPLC).Type: ApplicationFiled: October 8, 2010Publication date: July 19, 2012Inventors: Victor Samper, Marko Baller, Emiliano De Marco, Xavier Franci, Philippe DuMont, Sali Kuci, Colin Steel, Robin Fortt
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Publication number: 20120097301Abstract: A method of improving tire tread noise is provided. The method allows the identification of locations where the tread pattern should be particularly modified in order to optimize the level of noise created by the tread during tire operation. Variations in a defined parameter, contact length ratio, are used to determine one or more locations in the tread pattern where modification for noise reduction can be made. The type of modifications needed can also be indicated.Type: ApplicationFiled: July 15, 2009Publication date: April 26, 2012Applicant: MICHELIN RECHERCHE ET TECHNIQUEInventors: Fang Zhu, Frederic Xavier Francis Biesse