Abstract: The present invention relates to compounds of formula I: in which Y, Y1, Y4, Y5, Y6, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Abstract: The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Abstract: A computer network for asynchronously ingesting media content into a content management system (CMS) is disclosed. The network includes a client computer located in a first geographical location, a server computer located in a second geographical location and a liaison computer located in a third geographical location. The client computer communicates with the server computer by way of a substandard network connection that is subject to frequent interruptions and/or low bandwidth. The liaison computer communicates with the server computer by way of a reliable network. The client computer includes a user interface wizard component that edits and bundles media content and prompts a user to select between uploading content to the server computer by way of the substandard network (e.g. piecemeal between interruptions) or storing the content in a local mobile storage device for uploading from the liaison computer.

Abstract: The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Abstract: The invention concerns an osteosynthesis screw (1) formed from a core (2) externally provided with a helical thread (3), said screw comprising a distal penetration portion and a proximal portion forming the head of the screw (6) and having a conical longitudinal section characterised in that the proximal portion comprises annular notches which are formed in the thickness of the core (2) and in the gaps between the threads of said proximal portion in such a way as to reduce the radial pressure during screwing.—Surgical device.

Abstract: The present invention relates to compounds of formula I: in which Y, Y1, Y4, Y5, Y6, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Abstract: The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the tyrosine kinase enzymatic activity of the Abelson protein (ABL1), the Abelson-related protein (ABL2) and related chimeric proteins, in particular BCR-ABL1. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Abstract: The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Abstract: The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Abstract: Arthrodesis apparatus for first and second bones (2, 3), comprising a nail (5) and an instrument (20) for putting the nail (5) into place, the instrument comprising a base (21) and compression means (22, 23) comprising control means (22) for causing the nail to move relative to the base (21) and holder means (23) for holding the second bone (3) relative to the base (21); a guide (11) for the nail, the guide (11) and the holder (23) being arranged and shaped to cooperate together in such a manner to as allow the nail to move relative to the holder (23) and move the first bone (2) and the second bone (3) towards each other.

Abstract: An acoustic power transmitting unit for thermoacoustic systems includes at least one stage provided with at least two thermoacoustic units each of which includes a regenerator or a stack and two heat exchangers, an acoustic resonator including a tube and containing a fluid and in which a magnetic field having high impedance and low-impedance areas is arranged, wherein certain thermoacoustic units are placed in high dimensionless impedance areas. Each high dimensionless impedance area also includes a thermoacoustic unit, wherein two successive thermoacoustic units are always separated by low dimensionless impedance. The resonator includes a reduced diameter section between each couple of successive thermoacoustic units and each cross-sectional narrowing is associated with at least one by-pass which includes a deviation cavity and makes it possible to deviate the major part of a volume flow rate.

Abstract: The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Abstract: A method and apparatus (100) for vibrating an organ and/or tissue and/or region of a subject's body (202) without a mechanical transmission to characterize at least one mechanical property of the region and/or tissue and/or organ, the apparatus (100) includes: elements (114-118) for generating a pressure wave of a given frequency in a gaseous medium, and waveguide elements (106) for guiding, in a gaseous medium, the pressure wave from the generating elements (114-118) to a human or animal body (202). Wave guiding in the airways of a human or animal body and tissue displacement mapping, anisotropy, and mechanical property characterizing systems (300) and methods are also described.

Abstract: Disclosed herein is a device destined to be coupled to at least one support, and in particular a surgical implant destined to be coupled to a bone. The invention relates generally to a device (1) including a fixing element (3) including a head (3A) and a pin (3B) destined to be anchored in a support. The device further includes an assembly part (4) including a through hole (5), and a ring (6) housed in a manner that can be oriented within the through hole (5). The ring (6) has a passage (6A) shaped so as to allow passage of the pin (3B) and to stop the head (3A). The ring (6) is expandable according to its axial direction between a configuration wherein the ring (6) can be oriented and a configuration wherein the ring (6) is blocked.

Abstract: The invention relates to a device (1) comprising an assembling piece (3) provided with a hole (4), and a fixing element (5) having a shank (6) as well as head (7). The device (1) has a locking screw (8a) of the head (7), characterized in that the hole (4) is shaped for producing a stop (9) for the head and for enabling the head (7), when it rests against the stop (9), to be displaced inside the hole (4) in the plane of the cross-section of the hole (4), the hole (4) having an inside thread in which the locking screw (8A) is to be screwed so that the locking screw (8A) rests against the head (7) and thus presses the latter against the stop (9). The invention also relates to fixing devices, in particular, surgical implants.

Abstract: The invention provides an osteosynthesis and compression screw that is self-boring and self-tapping for the purpose of coaptation of small bone fragments. The screw comprises: a proximal portion formed by a screw head provided with an outside thread; an intermediate portion having no thread; and a distal portion provided with an outside thread. Wherein: each of the screw head and the distal portion includes at least one groove, firstly extending over the entire axial length of its thread, and secondly being formed through each thread in such a manner to form tapping means; and the terminal zone of the distal portion is provided with preparation means for preparing a housing in the bone fragments for receiving the intermediate and distal portions of the screw.

Abstract: A system includes a plurality of integrated circuits for propagating data between at least one central processing unit and another component of the system. The plurality of integrated circuits are configured for proximity I/O communication. The plurality of integrated circuits is configured such that data propagation through the plurality of integrated circuits is unaffected by a rotation of at least one of the plurality of integrated circuits by 90 degrees.

Abstract: The invention provides an osteosynthesis and compression screw that is self-boring and self-tapping for the purpose of coaptation of small bone fragments. The screw comprises: a proximal portion formed by a screw head provided with an outside thread; an intermediate portion having no thread; and a distal portion provided with an outside thread. Wherein: each of the screw head and the distal portion includes at least one groove, firstly extending over the entire axial length of its thread, and secondly being formed through each thread in such a manner to form tapping means; and the terminal zone of the distal portion is provided with preparation means for preparing a housing in the bone fragments for receiving the intermediate and distal portions of the screw.

Abstract: An electronic system in which integrated circuits employing cornered I/O are arranged in a framework including an optional path manager and at least one updateable routing table. Packet routing options are described with solutions being provided to minimize transmission latency and pathway alternatives.

Abstract: Arthrodesis apparatus for first and second bones (2, 3), comprising a nail (5) and an instrument (20) for putting the nail (5) into place, the instrument comprising a base (21) and compression means (22, 23) comprising control means (22) for causing the nail to move relative to the base (21) and holder means (23) for holding the second bone (3) relative to the base (21); a guide (11) for the nail, the guide (11) and the holder (23) being arranged and shaped to cooperate together in such a manner to as allow the nail to move relative to the holder (23) and move the first bone (2) and the second bone (3) towards each other.