Abstract: The subject of the invention is a degradable intrauterine system for the release of a haemostatic agent into the uterine cavity, comprising a degradable copolymer-based polymer matrix comprising at least one A and B block copolymer, and a haemostatic agent intended for release into the uterine cavity, wherein: block A is a polyester; block B is a poly(oxyethylene) (PEO); the weight-average molecular mass of the blocks B is a greater than or equal to 50 kDa; and the ethylene oxide unit/ester unit mole ratio is between 0.5 and 5. The invention also relates to a haemostatic agent for use in the treatment of uterine haemorrhage, wherein the haemostatic agent is delivered into the intrauterine cavity by means of a degradable intrauterine system according to the invention.

Abstract: The present invention relates to a microfluidic chip capable of attracting and trapping a specific biological element, said chip comprising: a reservoir (1) consisting of a matrix comprising a chemoattractant compound capable of attracting the biological element, and at least one array of microchannels (2) arranged between the reservoir (1) and the external medium (3) of the chip and enabling the chemoattractant compound to pass towards said medium and the biological element present in said medium to pass towards the reservoir (1), characterized in that each microchannel is in the form of a harpoon comprising at least two arrows spaced apart longitudinally and directed towards the reservoir, in which each arrow comprises two branches each having a free end forming an acute angle of between 10° and 80°, and in which each arrow comprises two openings (7) communicating with a longitudinal part of the microchannel and having a width of between 5 ?m and 30 ?m.

Abstract: The present invention relates to novel degradable branched-blockcopolymers, comprising a star-shaped copolymer central core or a linear copolymer central core, functionalized with photoreactive groups chosen among aryl-azide, (meth)acrylate or thiol groups. The present invention also relates to the use of these degradable branched-block copolymers as photo-crosslinkers to provide degradable photo-crosslinked elastomers as biomaterials suitable for medical and tissue engineering applications. A method for preparing a degradable photo-crosslinked polymer, preferably a degradable photo-crosslinked elastomer, starting from the branched-block copolymer of the invention via a shaping process and an irradiation step is also provided.

Abstract: The present invention relates to a microfluidic chip for attracting and destroying a specific biological element, said chip comprising: a reservoir (1) consisting of a matrix comprising a chemoattractant compound capable of attracting the biological element at least one network of microchannels (2) arranged between the reservoir (1) and the external environment (3) of the chip and allowing the chemoattractant compound to pass to said environment and the biological element present in said environment to pass to the reservoir (1) at least one electrode (4) arranged between the reservoir (1) and the network of microchannels (2) or at the same location as the network of microchannels (2), said electrode (4) being capable of generating an electric field so as to destroy the biological element during its passage to the reservoir (1).

Abstract: Disclosed is a composition based on copolymers including at least one A-B block copolymer, wherein block A is a polyester and block B is a polyoxyethylene (PEG), and wherein the total molecular mass in weight of the PEG is higher than or equal to 50 kDa, and the ethylene oxide motif/ester motif molar ratio is between 0.5 and 5. The invention also relates to an anti-adhesive material including such a composition, used for the prevention of tissue adhesions and especially for the prevention of intrauterine synechiae.

Abstract: The invention relates to a hydrophobic thermoplastic copolymer which is in particular of use for manufacturing and/or coating medical devices, in particular implantable medical devices, characterized in that it is obtained by copolymerization, and in that it comprises at least one first monomer unit and at least one second monomer unit onto which is grafted a paramagnetic-ion-chelating ligand which can complex with such a paramagnetic ion or a paramagnetic-ion-chelating ligand which is complexed with such a paramagnetic ion, wherein the second monomer unit is grafted in sufficient amount for the copolymer to be visible in magnetic resonance imaging when it is complexed with said paramagnetic ion. The invention also relates to a method for obtaining said hydrophobic thermoplastic copolymer.

Abstract: Disclosed is a composition based on copolymers including at least one A-B block copolymer, wherein block A is a polyester and block B is a polyoxyethylene (PEG), and wherein the total molecular mass in weight of the PEG is higher than or equal to 50 kDa, and the ethylene oxide motif/ester motif molar ratio is between 0.5 and 5. The invention also relates to an anti-adhesive material including such a composition, used for the prevention of tissue adhesions and especially for the prevention of intrauterine synechiae.

Abstract: A cell carrying microsphere composition, wherein the microsphere composition comprises a microspheric core comprising a triblock copolymer matrix A-B-A wherein A is selected from poly(lactide-co-glycolide) (PLGA) or polylactide (PLA) and B is poloxamer or poloxamine, wherein the microspheric core is coated with a cell adhesion coating and further comprises whole cells or cell fragments bonded to the cell adhesion coating, a process for the preparation of a cell carrying microsphere composition, and applications thereof.

Abstract: The present invention relates to a hydrophobic polymer used in particular to produce and/or coat medical devices, in particular implantable medical devices, that are visible in magnetic resonance imaging, characterized in that it comprises at least one monomer unit on which is grafted a chelating ligand of a paramagnetic ion complexed with such a paramagnetic ion, said monomer unit having at least one carbonyl group, said monomer unit comprising, prior to grafting, at least one hydrogen atom in the ? position of said at least one carbonyl group, and said grafting of the chelating ligand taking place in the area of said at least one hydrogen atom in the ? position of said at least one carbonyl group.

Abstract: A cell carrying microsphere composition, wherein the microsphere composition comprises a microspheric core comprising a triblock copolymer matrix A-B-A wherein A is selected from poly(lactide-co-glycolide) (PLGA) or polylactide (PLA) and B is poloxamer or poloxamine, wherein the microspheric core is coated with a cell adhesion coating and further comprises whole cells or cell fragments bonded to the cell adhesion coating, a process for the preparation of a cell carrying microsphere composition, and applications thereof.

Abstract: The invention relates to a hydrophobic thermoplastic copolymer which is in particular of use for manufacturing and/or coating medical devices, in particular implantable medical devices, characterized in that it is obtained by copolymerization, and in that it comprises at least one first monomer unit and at least one second monomer unit onto which is grafted a paramagnetic-ion-chelating ligand which can complex with such a paramagnetic ion or a paramagnetic-ion-chelating ligand which is complexed with such a paramagnetic ion, wherein the second monomer unit is grafted in sufficient amount for the copolymer to be visible in magnetic resonance imaging when it is complexed with said paramagnetic ion. The invention also relates to a method for obtaining said hydrophobic thermoplastic copolymer.

Abstract: The present invention relates to a hydrophobic polymer used in particular to produce and/or coat medical devices, in particular implantable medical devices, that are visible in magnetic resonance imaging, characterized in that it comprises at least one monomer unit on which is grafted a chelating ligand of a paramagnetic ion complexed with such a paramagnetic ion, said monomer unit having at least one carbonyl group, said monomer unit comprising, prior to grafting, at least one hydrogen atom in the a position of said at least one carbonyl group, and said grafting of the chelating ligand taking place in the area of said at least one hydrogen atom in the a position of said at least one carbonyl group.

Abstract: The invention mainly concerns a biocompatible and biodegradable porous matrix, characterized in that it is made of a three-block sequenced copolymer of formula (I): X G Y (I), wherein: G is a non-hydroxylated hydrophilic linear block, and X and Y represent respectively a hydrophobic linear polyester block. The invention further concerns the use of said matrix for coating tissue reconstruction after loss of substance or bioactive dressings.