Patents by Inventor Xavier I. Ambroggio

Xavier I. Ambroggio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of COP9 signalsome isopeptidase activity
    Patent number: 7279317
    Abstract: Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an autoimmune disease in a subject by modulating the CSN isopeptidase activity are provided, as are medicaments useful for treating a subject having such a condition.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: October 9, 2007
    Assignee: California Institute of Technology
    Inventors: Raymond J. Deshaies, Gregory Cope, Rati Verma, Xavier I. Ambroggio
  • Modulation of COP9 signalsome isopeptidase activity
    Publication number: 20030153097
    Abstract: Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an autoimmune disease in a subject by modulating the CSN isopeptidase activity are provided, as are medicaments useful for treating a subject having such a condition.
    Type: Application
    Filed: January 9, 2003
    Publication date: August 14, 2003
    Inventors: Raymond J. Deshaies, Gregory Cope, Rati Verma, Xavier I. Ambroggio