Patents by Inventor Xavier LUCAS

Xavier LUCAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZO[4,5-B]PYRIDINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
    Publication number: 20250127780
    Abstract: The invention relates to a compound of formula (I) wherein L, A1, A2, R1, R2, R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 18, 2024
    Publication date: April 24, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Guillaume DÉCORET, Katrin GROEBKE ZBINDEN, Wolfgang HAAP, Lukas KREIS, Xavier LUCAS CABRÉ, Jean-Yves WACH, Roger WERMUTH
  • PYRIDINE DERIVATIVES
    Publication number: 20250115607
    Abstract: The invention relates to a compound of formula (I) wherein A1, R1, R2, R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: December 18, 2024
    Publication date: April 10, 2025
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Guillaume DÉCORET, Katrin GROEBKE ZBINDEN, Wolfgang HAAP, Lukas KREIS, Xavier LUCAS CABRÉ, Etienne RAUBER
  • Benzimidazole Pyridine Derivatives
    Publication number: 20240383875
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2, A3, R1, R2, R2?, R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: July 18, 2024
    Publication date: November 21, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Mahendra AWALE, Stefan BERCHTOLD, Julie CHARPENTIER, Héloïse Marie Albine COLOMBANO, Guillaume DECORET, Katrin GROEBKE ZBINDEN, Nicole GROSSMANN, Wolfgang HAAP, Philip Anthony HARRIS, Jérôme HERT, Jonah Milton KALLENBACH, Christian KRAMER, Lukas KREIS, Danny KRUMM, Xavier LUCAS CABRE, Nenad MANEVSKI, Philippe PFLIEGER, Amir Mohsen POURMOUSA ABKENAR, Etienne RAUBER, Dazhi TAN, Jean-Yves WACH, Roger WERMUTH
  • PYRAZOLEAMIDE DERIVATIVES
    Publication number: 20230382911
    Abstract: The present invention provides compounds of formula I or II: wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: July 28, 2023
    Publication date: November 30, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Andrew Simon BELL, Jérémy BESNARD, Anthony Richard BRADLEY, Luke GREEN, Wolfgang HAAP, Buelent KOCER, Andreas KUGLSTATTER, Xavier LUCAS, Patrizio MATTEI, Dmitry MAZUNIN, Claus RIEMER, Willem Paul VAN HOORN
  • INHIBITORS OF PROTEINS SPECIFIC FOR THE SECRETOME OF A CHONDROCYTE FOR USE IN THE TREATMENT OF BREAST CANCER METASTASIS
    Publication number: 20200103409
    Abstract: The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.
    Type: Application
    Filed: October 16, 2019
    Publication date: April 2, 2020
    Inventors: PRASAD SHASTRI, JON CHRISTENSEN, XAVIER LUCAS, STEFAN GÜNTHER
  • INHIBITORS OF PROTEINS SPECIFIC FOR THE SECRETOME OF A CHONDROCYTE FOR USE IN THE TREATMENT OF BREAST CANCER METASTASIS
    Publication number: 20160069882
    Abstract: The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.
    Type: Application
    Filed: April 23, 2014
    Publication date: March 10, 2016
    Inventors: Prasad SHASTRI, Jon CHRISTENSEN, Xavier LUCAS, Stefan GÜNTHER
  • COMPOUNDS FOR USE AS BROMODOMAIN INHIBITORS
    Publication number: 20160068485
    Abstract: A compound of formula (1), (1?), (1?) or (1??) or a pharmaceutically acceptable salt thereof, for use in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.
    Type: Application
    Filed: April 15, 2014
    Publication date: March 10, 2016
    Inventors: Stefan GÜNTHER, Xavier LUCAS, Manfred JUNG, Oliver EINSLE, Daniel WOHLWEND, Stefan GERHARDT