Patents by Inventor Xavier Muller

Xavier Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Perfusion Loop Assembly for an Ex-Vivo Liver Perfusion and a Method for Ex-Vivo Liver Perfusion
    Publication number: 20200375178
    Abstract: A perfusion loop assembly for ex vivo liver perfusion includes a pump providing perfusion fluid through a line branching at a branching point into a first branch line and a second branch line. The first branch line provides a first portion of the perfusion fluid to the hepatic artery of the liver, the first branch line coupled with a gas exchanger, where the first branch line includes a flow rate sensor and/or a pressure sensor. The second branch line provides a second portion of the perfusion fluid to the portal vein of the liver; the second branch line includes a valve for controlling flow of perfusion fluid into the portal vein. The second branch line includes a flow rate sensor and/or a pressure sensor. A liver chamber assembly holds the liver ex vivo, and an outlet line for the perfusion fluid connects the liver chamber assembly and the pump.
    Type: Application
    Filed: January 18, 2019
    Publication date: December 3, 2020
    Inventors: Dustin Becker, Dilmurodjon Eshmuminov, Max Leo Hefti, Martin Jörg Schuler, Philipp Rudolf von Rohr, Pierre-Alain Clavien, Rolf Graf, Lucia Bautista Borrego, Xavier Muller, Philipp Dutkowski
  • METHOD OF TREATING THROMBOCYTOPENIA
    Publication number: 20160143883
    Abstract: Invented is a method of treating thrombocytopenia in a human in need thereof which comprises the administration of a therapeutically effective amount of a 3?-{N?-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2?-hydroxybiphenyl-3-carboxylic acid to such human.
    Type: Application
    Filed: December 21, 2015
    Publication date: May 26, 2016
    Applicant: NOVARTIS AG
    Inventors: Shivakumar G. Kapsi, Francis Xavier Muller, Mary Beth Wire
  • METHOD OF TREATING THROMBOCYTOPENIA
    Publication number: 20140142155
    Abstract: Invented is a method of treating thrombocytopenia in a human in need thereof which comprises the administration of a therapeutically effective amount of a 3?-{N?-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2?-hydroxybiphenyl-3-carboxylic acid to such human.
    Type: Application
    Filed: January 8, 2014
    Publication date: May 22, 2014
    Applicant: GlaxoSmithKline LLC
    Inventors: SHIVAKUMAR G. KAPSI, FRANCIS XAVIER MULLER, MARY BETH WIRE
  • Process, salts, composition and use
    Patent number: 8207191
    Abstract: The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or solvates thereof, novel pharmaceutical compositions or formulations for topical administration comprising mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or a pharmaceutically acceptable salt or solvate thereof and their use in medical therapy, particularly antibacterial therapy.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: June 26, 2012
    Assignee: Glaxo Group Limited
    Inventors: Michael Anthony Forth, Susan ShuMei Hu Kopelman, Francis Xavier Muller, Francis Dominic Sanderson
  • METHOD OF TREATING THROMBOCYTOPENIA
    Publication number: 20120149749
    Abstract: Invented is a method of treating thrombocytopenia in a human in need thereof which comprises the administration of a therapeutically effective amount of a 3?-{N?-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2?-hydroxybiphenyl-3-carboxylic acid to such human.
    Type: Application
    Filed: October 14, 2009
    Publication date: June 14, 2012
    Inventors: Michael Arning, Manuel Carlos Alves-Aivado, Roya Behbahani, Yanli Deng, Connie L. Erickson-Miller, Sophia M. Goodison, Julian Jenkins, Shivakumar G. Kapsi, Bhabita Mayer, Francis Xavier Muller, Bin Peng, Teresa S. Sellers, Nicole Lee Stone, Dickens Theodore, Dennis R. Williams, Mary Beth Wire
  • NOVEL PROCESS, SALTS, COMPOSITION AND USE
    Publication number: 20110144151
    Abstract: The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or solvates thereof, novel pharmaceutical compositions or formulations for topical administration comprising mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or a pharmaceutically acceptable salt or solvate thereof and their use in medical therapy, particularly antibacterial therapy.
    Type: Application
    Filed: December 23, 2010
    Publication date: June 16, 2011
    Inventors: Gary Francis Breen, Michael Anthony Forth, Susan ShuMei Hu Kopelman, Francis Xavier Muller, Francis Dominic Sanderson
  • Process salts compositions and use
    Patent number: 7875630
    Abstract: The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or solvates thereof, novel pharmaceutical compositions or formulations for topical administration comprising mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetate or a pharmaceutically acceptable salt or solvate thereof and their use in medical therapy, particularly antibacterial therapy.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: January 25, 2011
    Assignee: Glaxo Group Limited
    Inventors: Gary Francis Breen, Michael Anthony Forth, Susan ShuMei Hu Kopelman, Francis Xavier Muller, Francis Dominic Sanderson