Abstract: Process for the treatment of painful syndromes, especially local and/or visceral, consisting in the parenteral or topical administration of a therapeutically effective quantity of the (-) tartrate of (+)-(R)-1-[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-prop ylamine.

Abstract: The present invention relates to propanamines of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted in an identical or different manner with halogen atoms, or lower alkyl, lower haloalkyl or lower alkoxy radicals;R2 is a lower alkyl radical,R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkyalkyl radical,R5 is a 5-to 7-membered cycloalkyl radical or a phenyl radical, andW represents a heterocycle .dbd.C[Q--(CH.sub.2).sub.n --Q] in which Q is an oxygen or sulfur atom and n is 2 or 3,and their acid addition salts with pharmaceutically acceptable acids. The invention also relates to antidiarrheal pharmaceutical compositions comprising the claimed propanamines.

Abstract: A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted,or is a 5- or 6-membered monocyclic heteroaryl radical in which the single heteroatom is nitrogen, oxygen or sulfur,R2 is a lower alkyl radical,R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkylalkyl radical,or, together with the nitrogen atom to which they are attached, form a saturated 5- to 6-membered heterocycle comprising only one heteroatom,R5 is a 5- to 7-membered cycloalkyl radical, a phenyl radical or a 5- or 6-membered monocyclic heteroaryl radical,and W representsa group .dbd.CH--QH,or a heterocycle .dbd.C[Q--(CH2)n--Q],or a group .dbd.C.dbd.Q, in which groupsQ is an oxygen or sulfur atom,n has the value 2 or 3,W being .dbd.C.dbd.Q only when R3 and R4 are not both hydrogen, and their additions salts with pharmaceutically acceptable acids.

Abstract: N-Cycloalkylalkylamines of formula I: ##STR1## in which: R1 is phenyl which is optionally mono-, di- or trisubstituted by halogens or lower alkyl, haloalkyl or lower alkoxy radicals, or is an aromatic heterocyclic radical having 5 to 7 chain members, in which the hetero atom is nitrogen, oxygen or sulphur,R2 is lower alkyl,R3 is hydrogen or lower alkyl,m has the value of 1 or 2,R4 is cycloalkyl --CH(CH2)n, in which a carbon atom may carry a radical Rx, which is lower alkyl or phenyl; and in which n has the values from 2 to 5,R5 is phenyl, which can be mono-, di- or trisubstituted by halogens or by lower alkoxy radicals, andQ represents an ethylene-1,2-diyl group --CH.dbd.

Abstract: This invention relates to novel N-acyl anilines, to a process for their preparation and to pharmaceutical compositions containing them. The N-acyl anilines are obtained by condensing a substituted aniline with an aminolower alkyl carboxylic acid or a functional derivative thereof.The compounds of the invention have therapeutic utility namely in the gastro-enterologic field.

Abstract: The present application relates to pharmaceutical compositions incorporating as active ingredient p.chlorohippuric acid or one of its mineral or organic base addition salts.The pharmaceutical compositions are those adapted for parenteral or oral administration. They may include another active ingredient.The present application also extends to therapeutic methods for using the said pharmaceutical compositions namely for protecting the gastric mucosa from acid hypersecretion, ulcers from therapeutic origin and for protecting the liver from toxic aggressions.

Abstract: This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof.The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.

Abstract: This invention relates to novel N-acyl anilines, to a process for their preparation and to pharmaceutical compositions containing them. The N-acyl anilines are obtained by condensing a substituted aniline with an aminolower alkyl carboxylic acid or a functional derivative thereof.The compounds of the invention have therapeutic utility namely in the gastro-enterologic field.

Abstract: This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.This invention also relates to processes for making the same in which an ortho-alkoxy aniline is reacted with a lower alkanoic acid or a functional derivative thereof.The compounds of the invention have therapeutical utility namely for the prevention or treatment of digestive disorders and gastric ulcers.

Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.

Abstract: This application relates to benzenesulphonamides and more specifically to 1-acylamino 2- alcoxy or alcenyloxy 5-morpholinylsulfonyl benzenes and their salts with a mineral or organic acid. It also relates to processes for producing these compounds.The disclosed compounds are useful for stimulating gastric evacuation while inhibiting emisis and gastric secretion in warm-blooded animals.

Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.

Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.

Abstract: This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.

Abstract: Disubstituted azabicycloalkanes of the formula ##SPC1##Wherein:n is 0, 1 or 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.

Abstract: Heterocyclic amides of the formula: ##EQU1## wherein: X is N or CH;n is O or 1 andR is ##EQU2## wherein: R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar - A- or ##EQU3## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methylenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.

Abstract: Heterocyclic amides of the formula: ##SPC1##Wherein:X is N or CH;n is O or 1 andR is ##EQU1## or ##SPC2##Wherein:R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar -- A-- or Ar ##EQU2## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methlenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.