Abstract: The invention relates to using a graph database in genetic analyses to link mutation data to extrinsic data. Entities such as mutations, patients, samples, alleles, and clinical information are individually represented and stored as nodes and relationships between entities are also individually represented and stored. Each node and relationship can be stored using a fixed-size record and nodes can be flexibly invoked to represent any entity without disrupting the existing data. Systems and methods of the invention may be used for obtaining data representing a mutation in an individual and using a node in a graph database to store a description of the mutation. The node has stored within it a pointer to an adjacent node that provides information about a clinical significance of the variant. The graph database can be queried to provide a report of the clinical significance of the mutation.

Abstract: The invention provides a system and method for describing polymorphisms or genetic variants based on information about mutations and relationships among them. The invention uses object-oriented concepts to describe variants as variant objects and relations among those variants as variant relation object, each object being an instance of an abstract class of genomic feature and able to contain any number of other objects. Information about genetic disorders is stored in association with the object that represents the pathogenic variant. Genetic test results are used to access corresponding objects to provide a report based on variants or polymorphisms in a patient's genetic material.

Abstract: The invention relates to using a graph database in genetic analyses to link mutation data to extrinsic data. Entities such as mutations, patients, samples, alleles, and clinical information are individually represented and stored as nodes and relationships between entities are also individually represented and stored. Each node and relationship can be stored using a fixed-size record and nodes can be flexibly invoked to represent any entity without disrupting the existing data. Systems and methods of the invention may be used for obtaining data representing a mutation in an individual and using a node in a graph database to store a description of the mutation. The node has stored within it a pointer to an adjacent node that provides information about a clinical significance of the variant. The graph database can be queried to provide a report of the clinical significance of the mutation.

Abstract: The invention provides a system and method for describing polymorphisms or genetic variants based on information about mutations and relationships among them. The invention uses object-oriented concepts to describe variants as variant objects and relations among those variants as variant relation object, each object being an instance of an abstract class of genomic feature and able to contain any number of other objects. Information about genetic disorders is stored in association with the object that represents the pathogenic variant. Genetic test results are used to access corresponding objects to provide a report based on variants or polymorphisms in a patient's genetic material.

Abstract: The invention provides a system and method for describing polymorphisms or genetic variants based on information about mutations and relationships among them. The invention uses object-oriented concepts to describe variants as variant objects and relations among those variants as variant relation object, each object being an instance of an abstract class of genomic feature and able to contain any number of other objects. Information about genetic disorders is stored in association with the object that represents the pathogenic variant. Genetic test results are used to access corresponding objects to provide a report based on variants or polymorphisms in a patient's genetic material.

Abstract: The invention provides a system and method for describing polymorphisms or genetic variants based on information about mutations and relationships among them. The invention uses object-oriented concepts to describe variants as variant objects and relations among those variants as variant relation object, each object being an instance of an abstract class of genomic feature and able to contain any number of other objects. Information about genetic disorders is stored in association with the object that represents the pathogenic variant. Genetic test results are used to access corresponding objects to provide a report based on variants or polymorphisms in a patient's genetic material.

Abstract: A system and method including a DAC that receives a multi-bit digital signal and outputs at least two analog signals including a first analog signal and a second analog signal, the first analog signal being indicative of a sum of values of bits in the multi-bit digital signal, the second analog signal also being indicative of said sum of values of said bits in the multi-bit digital signal. The first and second analog signals may be substantially equal or they may be different from each other.

Abstract: Systems and methods receive a digital signal and generate an analog signal indicative thereof. In one embodiment, a system includes a DAC that receives a multi-bit digital signal, generates at least two analog signals each indicative of the value of the multi-bit digital signal, and filters two or more of the at least two analog signals. In another embodiment, a system includes a DAC that receives digital input signals at an input data rate and outputs analog signals indicative of the digital signals to a signal conditioning stage at an output data rate different than the input data rate.

Abstract: Systems and methods receive a digital signal and generate an analog signal indicative thereof. In one embodiment, a system includes a DAC that receives a multi-bit digital signal, generates at least two analog signals each indicative of the value of the multi-bit digital signal, and filters two or more of the at least two analog signals. In another embodiment, a system includes a DAC that receives digital input signals at an input data rate and outputs analog signals Indicative of the digital signals to a signal conditioning stage at an output data rate different the input data mute.

Abstract: An offset calibration system includes an analog to digital converter having a first full-scale range with a first offset compensation circuit; a digital to analog converter having a second full-scale range with a second offset compensation circuit; the digital to analog converter having its output connected to the input of the analog to digital converter during calibration of the digital to analog converter; and a range adjustment circuit for accumulating a predetermined number of analog to digital output values and dividing the accumulated values by a preselected power of 2 in the ratio of the voltage corresponding to the analog to digital converter least significant bit to the voltage corresponding to the digital to analog converter least significant bit.