Patents by Inventor Xenia WEZLER

Xenia WEZLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR SELECTING CELL CLONES EXPRESSING A HETEROLOGOUS POLYPEPTIDE
    Publication number: 20240151720
    Abstract: Herein is reported a novel, high throughput suitable method for the characterization and identification as well as selection of recombinant cell clones expressing a bispecific antibody with high titers and low levels of antibody-related side products. The method according to the current invention uses the binding signals of an immunoassay-based screening of recombinant cell clone cultivation supernatants for isolated as well as simultaneous binding to the respective targets of the antibody. This data allows for the selection of high producer cell clones with desired product profile.
    Type: Application
    Filed: October 6, 2023
    Publication date: May 9, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Tobias Grosskopf, Xenia Wezler
  • NATRIURETIC PEPTIDE RECEPTOR 1 ANTIBODIES AND METHODS OF USE
    Publication number: 20230365674
    Abstract: This disclosure relates to anti-Natriuretic Peptide Receptor 1 (NPR1) antibodies including agonist antibodies which are able to activate the NPR1 receptor, pharmaceutical compositions comprising the same, and methods of treatment comprising the same.
    Type: Application
    Filed: March 30, 2023
    Publication date: November 16, 2023
    Inventors: John Louis DIENER, Lars GADTKE, Felix HARTLEPP, Tiancen HU, Kathrin LADETZKI-BAEHS, Michael John ROMANOWSKI, Cesare RUSSO, Xenia WEZLER, Xiaoling XIE
  • NATRIURETIC PEPTIDE RECEPTOR 1 ANTIBODIES AND METHODS OF USE
    Publication number: 20220356242
    Abstract: This disclosure relates to anti-Natriuretic Peptide Receptor 1 (NPR1) antibodies including agonist antibodies which are able to activate the NPR1 receptor, pharmaceutical compositions comprising the same, and methods of treatment comprising the same.
    Type: Application
    Filed: June 16, 2021
    Publication date: November 10, 2022
    Inventors: John Louis DIENER, Lars GADTKE, Felix HARTLEPP, Tiancen HU, Kathrin LADETZKI-BAEHS, Michael John ROMANOWSKI, Cesare RUSSO, Xenia WEZLER, Xiaoling XIE
  • Natriuretic peptide receptor 1 antibodies and methods of use
    Patent number: 11066469
    Abstract: This disclosure relates to anti-Natriuretic Peptide Receptor 1 (NPR1) antibodies including agonist antibodies which are able to activate the NPR1 receptor, pharmaceutical compositions comprising the same, and methods of treatment comprising the same.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: July 20, 2021
    Assignee: NOVARTIS AG
    Inventors: John Louis Diener, Lars Gadtke, Felix Hartlepp, Kathrin Ladetzki-Baehs, Michael Romanowski, Cesare Russo, Xenia Wezler
  • NATRIURETIC PEPTIDE RECEPTOR 1 ANTIBODIES AND METHODS OF USE
    Publication number: 20200392225
    Abstract: This disclosure relates to anti-Natriuretic Peptide Receptor 1 (NPR1) antibodies including agonist antibodies which are able to activate the NPR1 receptor, pharmaceutical compositions comprising the same, and methods of treatment comprising the same.
    Type: Application
    Filed: June 10, 2020
    Publication date: December 17, 2020
    Inventors: John Louis DIENER, Lars GADTKE, Felix HARTLEPP, Tiancen HU, Kathrin LADETZKI-BAEHS, Michael ROMANOWSKI, Cesare RUSSO, Xenia WEZLER, Xiaoling XIE