Abstract: A deep-sea crawling robot and a crawling method thereof are provided. The deep-sea crawling robot includes a crawling robot body and a countertop, wherein a top of the crawling robot body is fixedly connected to the countertop, left and right sides of a bottom of the crawling robot body are respectively provided with crawler belts, and left and right sides of the countertop are respectively provided with weight-increasing auxiliary crawling mechanisms; and an outer plate is fixedly connected to a front side or back side of the countertop, a multifunctional propelling mechanism is arranged on the outer plate, and a rapid dewatering mechanism is arranged in a chamber of the countertop. The deep-sea crawling robot can not only accelerate the propulsion and crawling speed when it is on the seabed but also further enhance its stability during the crawling process on the seabed.

Abstract: An apparatus of salt cavern gas storage without cushion gas includes: a salt cavern; sediments; a drainage assembly; a gas injection and production pipe; a debrining string, one end of which is connected to the drainage assembly, and the other end of which protrudes from the ground to be connected to a water source assembly; a communicating assembly, which is used to make the gas injection and production pipe be in communication with the debrining string on the ground. A closed loop is formed by making the gas injection and production pipe and the debrining string be in communication with each other on the ground through the communicating assembly, thus the non-cushion gas injection-production operation of sediment particles in the salt cavern is realized.

Abstract: A bottom touching assisting device suitable for deep-sea submersibles and an implementation method thereof are provided. Four support columns are arranged within a mounting box body at a bottom of a deep-sea submersible, the support columns and the mounting box body are connected in a sliding manner through sliders, and the support column is sleeved with a threaded sleeve in a threaded connection manner. In conjunction with a drive component and a pressing mechanism, smooth vertical movement of the support column is achieved when the threaded sleeve rotates. This allows a bottom end of the support column to extend from the mounting box body.

Abstract: The present disclosure provides for a compound according to formula (I) or a pharmaceutically acceptable salt thereof as CaV1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.

Abstract: A method protects a daemon in an operating system of a host computer. The operating system detects that there is an access of a plist file of a daemon by a process in the computer. If so, then it executes a callback function registered for the plist file. The callback function sends to a kernel extension a notification of the attempted access. The kernel extension returns a value to the operating system indicating that the access should be denied. The operating system denies access to the plist file of the daemon by the process. The extension may also notify an application which prompts the user for instruction. The kernel extension also protects itself by executing its exit function when a command is given to unload the extension, and the exit function determines whether or not the command is invoked by an authorized application, such as by checking a flag.

Abstract: Biomarkers that can be used for the detection or diagnosis of disease states, preferably inflammatory bowel disease states, the identification of a treatment regimen for inflammatory bowel disease, and/or to indicate the responsiveness to the treatment regimen for inflammatory bowel disease in a subject are described. Also described are probes capable of detecting the biomarkers and related methods and kits for determining inflammatory bowel disease states and/or identification of treatment regimens for the inflammatory bowel disease states.

Abstract: Disclosed are a method and an apparatus for wireless network configuration, a storage medium and a processor. The method includes: monitoring an execution result of a network configuration step in a wireless network configuration process; determining a corresponding failure reason when the execution result of the network configuration step is failure; and executing an operation corresponding to the failure reason. The operation comprises one of the following: outputting prompt information containing the failure reason and adjusting parameters of a network configuration device.

Abstract: Biomarkers that are indicative of the response to the therapy of the inflammatory bowel disease, including ulcerative colitis (UC) and Crohn's disease (CD), are described. Also described are probes capable of detecting the biomarkers and related methods and kits for predicting the response to the therapy of the inflammatory bowel disease.

Abstract: A method protects a daemon in an operating system of a host computer. The operating system detects that there is an access of a plist file of a daemon by a process in the computer. If so, then it executes a callback function registered for the plist file. The callback function sends to a kernel extension a notification of the attempted access. The kernel extension returns a value to the operating system indicating that the access should be denied. The operating system denies access to the plist file of the daemon by the process. The extension may also notify an application which prompts the user for instruction. The kernel extension also protects itself by executing its exit function when a command is given to unload the extension, and the exit function determines whether or not the command is invoked by an authorized application, such as by checking a flag.

Abstract: An echo cancellation method includes receiving an echo reference signal, receiving a microphone signal, decomposing, with a first filter bank, the echo reference signal into a series of subband echo reference signals, decomposing, with a second filter bank, the microphone signal into a series of subband microphone signals, estimating a group delay between the echo reference signal and the microphone signal using the series of subband echo reference signals and the series of subband microphone signals, estimating, using adaptive filters, acoustic echoes in the echo reference signal based at least in part on the group delay, subtracting the acoustic echoes from the series of subband microphone signals to obtain a series of acoustic echo removed subband signals, combining the series of acoustic echo removed subband signals into a single time domain echo removed signal, and sending the single time domain echo removed signal to a host operating system.

Abstract: An echo cancellation method includes receiving an echo reference signal, receiving a microphone signal, decomposing, with a first filter bank, the echo reference signal into a series of subband echo reference signals, decomposing, with a second filter bank, the microphone signal into a series of subband microphone signals, estimating a group delay between the echo reference signal and the microphone signal using the series of subband echo reference signals and the series of subband microphone signals, estimating, using adaptive filters, acoustic echoes in the echo reference signal based at least in part on the group delay, subtracting the acoustic echoes from the series of subband microphone signals to obtain a series of acoustic echo removed subband signals, combining the series of acoustic echo removed subband signals into a single time domain echo removed signal, and sending the single time domain echo removed signal to a host operating system.

Abstract: A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.

Abstract: Methods of treating disorders related to Oxytocin Receptor activity utilize OXYTOCIN RECEPTOR antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, small molecule drugs, siRNA, shRNA, and DNAzymes. Disorders related to Oxytocin Receptor activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD.

Abstract: A method for prognostic or diagnostic assessment of a skin-related disorder, such as psoriasis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.

Abstract: A method for assessment of the suitability of a target therapy for a gastrointestinal-related disorder, such as ulcerative colitis, in a subject evaluates the presence, absence, and/or magnitude of expression of one or more genes in a 19- or 5-member gene panel in a sample. The method enables identification of the effectiveness of target therapies prior to starting a patient on such therapies.

Abstract: A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.

Abstract: A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.

Abstract: CNGH0011 polypeptides and nucleic acids encoding a variety of proteins have diagnostic, preventive, therapeutic, and other uses for a number of human and other animal disorders. Nucleic acid antagonist molecules (siRNA, shRNA, among others), expression vectors containing nucleic acid molecules, host cells into which the expression vectors have been introduced, fusion polypeptides, antigenic peptides and antibodies can be utilized to control the level of protein and regulate a variety of cellular processes in diagnostic, screening, and therapeutic methods.