Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: The present disclosure provides a method for testing an internal force increment of an arch bridge suspender by inertial measurement, including the following steps: (1) selecting a suspender to be tested with internal force increment, and mounting an acceleration sensing device or a speed sensing device at a lower edge of the suspender to be tested; (2) setting an appropriate sampling frequency and collecting signals; (3) processing information data collected in step (2) by using Formulas; and (4) recording a result of the information data processing and obtaining the internal force increment of the suspender. The method can obtain the internal force increment of the suspender by collecting acceleration or speed signals of the lower edge of the suspender and performing calculation from the signals. This method has the advantages of simple and convenient testing, high replicability and low test cost.

Abstract: The present disclosure relates to service level agreement (SLA) performance prediction methods, apparatuses, and devices. In one example method, a first network device obtains timestamps and packet lengths of a plurality of data packets. The first network device determines an arrival time interval of each of the plurality of data packets based on the timestamps of the plurality of data packets, where arrival time intervals of the plurality of data packets constitute a time interval sequence according to an arrival order. The first network device determines time domain feature parameters of the plurality of data packets based on a Markovian arrival process (MAP) model and the time interval sequence.

Abstract: The present disclosure relates to capacity planning methods and apparatus. One example method includes matching a distribution model based on a quantity of service packets in each transmission time interval within specified duration to obtain a matched first distribution model, matching a distribution model based on a length of the service packets to obtain a second distribution model, and performing bandwidth control based on the first distribution model, the second distribution model, a distribution parameter of the first distribution model, and a distribution parameter of the second distribution model.

Abstract: A method for positioning key features of a lens based on ocular B-mode ultrasound images includes: acquiring and preprocessing the ocular B-mode ultrasound images to obtain a preprocessed B-mode ultrasound image, eyeball coordinates and lens coordinates; sending the preprocessed B-mode ultrasound image, the eyeball coordinates and the lens coordinates into a trained target detection network YOLOv3 to obtain eyeball position images and lens position images; substituting the eyeball position images and the lens position images into a trained feature extraction network group to obtain image features and feature coordinates corresponding to the eyeball position images and the lens position images, respectively; substituting the image features into a trained collaborative learning network to screen key image features; and marking a feature coordinate corresponding to the key image features on the ocular B-mode ultrasound images to complete positioning the key features of the lens.

Abstract: A brazing apparatus and method for brazing an anode target plate of an X-ray generator are disclosed. The brazing apparatus comprises: a vacuum part for providing, during brazing, a vacuum environment at least for a target plate main body formed of an alloy, a brazing material, and a substrate; an induction brazing part for applying an induction current to the target plate main body, the brazing material and the substrate in the vacuum part so as to achieve heating to a temperature higher than the melting point of the brazing material, causing the substrate to be welded to the target plate main body through melting of the brazing material and a resulting reaction; and a directional energy welding part for applying a generated directional energy beam to a position of lower temperature determined on the target plate main body to perform heating.

Abstract: The present disclosure provides a weaving method of a weft-backed jacquard fabric with color shading effects and belongs to the technical field of weaving methods. In a single-warp and double-weft structure with a weft yarn arrangement ratio of Wefts A and Wefts B of 2:1, by designing two groups of face weaves and backing weaves and corresponding backed points and using a shaded strengthening method, two color shading effects of color shading of the Wefts A and mixed color shading of the Wefts A and the Wefts B of the fabric are achieved. A maximum number of shaded weaves is [R/N(6R?2J2?J1?3)+2], and a grade number of shaded color is less than or equal to the maximum number of the shaded weaves. The designed fabric meets the covering requirements and can be mass produced.

Abstract: The present disclosure provides a method for static identification of damage to a simply supported beam under an uncertain load. In this identification method, a beam body is first segmented, and the relationships between key measured sectional rotation angles and the flexural rigidities of segments of a structure under the action of a load are established by using a mechanics principle; then, an applied static load is removed by means of a division operation, and the relative relationships between the flexural rigidities of the segments of the structure are obtained; and finally, these relative relationships are compared with the corresponding relative relationships when the structure is not damaged, so as to determine the position of damage to the structure and assess the amount of damage, such that the static identification for damage to a simply supported beam structure can be completed without calibrating a load in advance.

Abstract: Evaluating the performance of an X-ray tube by: recording arcing events that occurred during the use of the X-ray tube; classifying the arcing events by severity; generating, on the basis of the classified arcing events, a first growth pattern for occurrences of arcing events; and determining a level of bubbles in the X-ray tube by finding, on the basis of the first growth pattern, a matching second growth pattern associated with a known level of bubbles in the X-ray tube. An X-ray tube may be checked and replaced in a timely manner, without the need for an on-site inspection, by remotely predicting trends or patterns for growth of levels of bubbles in the X-ray tube.

Abstract: Compositions that include anti-cancer, anti-tumor, and anti-microbial infection peptides are provided. In some embodiments, the compositions include 1-10 or more synthetic peptides that are between 8 and 50 amino acids long and include an amino acid sequence as disclosed herein.

Abstract: The objective of the present disclosure is to provide a method, apparatus and system of ACK/NACK reporting for Cat-M mechanism. Here, a user equipment feeds back an ACK/NACK message to an eNB on PUSCH based on received downlink data, wherein when computing the number of resource elements occupied by the ACK/NACK message on PUSCH, the number of OFDM symbols in a guard period is ruled out. This may effectively lower the UE's PUSCH data code rate, and meanwhile enhance the eNB's decoding performance on PUSCH.

Abstract: Provided are compositions that include one or more synthetic target peptides, wherein each synthetic target peptide is about or at least 8-50 amino acids long; and has an amino acid sequence as set forth in Table 2 and/or Table 3. Also provided are in vitro populations of dendritic cells that include the disclosed compositions, in vitro population of CD8+ T cells capable of being activated upon being brought into contact with the disclosed populations of dendritic cells, antibodies or antibody-like molecules that specifically binds to a complex of an MHC class I molecule and a peptide having an amino acid sequence as set forth in Table 2 and/or Table 3, methods for treating and/or preventing cancers by administering a therapeutically effective dose of a composition that includes at least one target peptide having an amino acid sequence as set forth in Table 2 and/or Table 3.

Abstract: Aspects of the subject disclosure may include, for example, a method comprising: receiving, by a processing system including a processor, an input three-dimensional dataset comprising a first plurality of two-dimensional images of all or a portion of a subject; applying, by the processing system, bias field correction to the input three-dimensional dataset to generate a corrected three-dimensional dataset comprising a second plurality of two-dimensional images; and generating, by the processing system, a labeled three-dimensional dataset comprising a third plurality of two-dimensional images, wherein the labeled three-dimensional dataset further comprises one or more labels indicating an anatomical structure, and wherein the labeled three-dimensional dataset is generated via a convolutional neural network based upon the corrected three-dimensional dataset and based upon a previously trained three-dimensional dataset. Additional embodiments are disclosed.

Abstract: The present disclosure provides a weaving method of a weft-backed jacquard fabric with color shading effects and belongs to the technical field of weaving methods. In a single-warp and double-weft structure with a weft yarn arrangement ratio of Wefts A and Wefts B of 2:1, by designing two groups of face weaves and backing weaves and corresponding backed points and using a shaded strengthening method, two color shading effects of color shading of the Wefts A and mixed color shading of the Wefts A and the Wefts B of the fabric are achieved. A maximum number of shaded weaves is [R/N(6R?2J2?J1?3)+2], and a grade number of shaded color is less than or equal to the maximum number of the shaded weaves. The designed fabric meets the covering requirements and can be mass produced.

Abstract: A brazing apparatus and method for brazing an anode target plate of an X-ray generator are disclosed. The brazing apparatus comprises: a vacuum part for providing, during brazing, a vacuum environment at least for a target plate main body formed of an alloy, a brazing material, and a substrate; an induction brazing part for applying an induction current to the target plate main body, the brazing material and the substrate in the vacuum part so as to achieve heating to a temperature higher than the melting point of the brazing material, causing the substrate to be welded to the target plate main body through melting of the brazing material and a resulting reaction; and a directional energy welding part for applying a generated directional energy beam to a position of lower temperature determined on the target plate main body to perform heating.