Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Abstract: An apparatus for use in decoding a bar code symbol may include an image sensor integrated circuit having a plurality of pixels, timing, and control circuitry for controlling an image sensor, gain circuitry for controlling gain, and analog to digital conversion circuitry for conversion of an analog signal to a digital signal. The apparatus may also include a printed circuit board for receiving the image sensor integrated circuit. The connection between the image sensor integrated circuit and the printed circuit board characterized by a plurality of conductive adhesive connectors disposed between a plurality of electrode pads and a plurality of contact pads, where the conductive adhesive connectors provide electrical input/output and mechanical connections between the image sensor integrated circuit and the printed circuit board. The apparatus may be operative for processing image signals generated by the image sensor integrated circuit for attempting to decode the bar code symbol.

Abstract: An encoded information reading (EIR) terminal can comprise a microprocessor communicatively coupled to a system bus, a memory, a communication interface, and a pluggable imaging assembly identified by a type identifier and configured to acquire an image comprising decodable indicia. The imaging assembly can comprise a two-dimensional image sensor configured to output an analog signal representative of the light reflected by an object located within the field of view of the imaging assembly. The EIR terminal can be configured to output, by processing the analog signal, the raw image data derived from the analog signal and/or a decoded message corresponding to the decodable indicia. The imaging assembly can be communicatively coupled to the system bus via an imaging assembly interface comprising a plurality of wires and a multi-pin connector. The imaging assembly interface can comprise one or more wires configured to carry the imaging assembly type identifier.

Abstract: An apparatus for use in decoding a bar code symbol includes a first integrated circuit chip with a wafer level camera, at least one light source, and a plurality of contact pads on a surface of the chip and a second integrated circuit chip with a processor, memory, plurality of contact pads on a surface of the chip, and plurality of contact pads on another surface of the chip. The apparatus includes a PCB having a plurality of contact pads disposed on at least one surface of the PCB and wherein the first and second integrated circuit chips are vertically stacked on the PCB and the plurality of contact pads on the first and second integrated circuit chips interface with the contact pads of the second integrated circuit chip and PCB. The apparatus is operative for processing image signals generated by the WLC for attempting to decode the bar code symbol.

Abstract: There is set forth herein an indicia reading terminal having data format conversion capabilities. The indicia reading terminal includes an image sensor integrated circuit with an image sensor array comprising a plurality of pixels. The image sensor integrated circuit is configured to output image data in a first data format to a data formatting circuit for conversion to image data in a second data format. The data formatting circuit is configured to provide the image data in the second data format to the at least one data interface of a microprocessor integrated circuit, which is operative to transfer image data received by the at least one data interface into memory of the indicia reading terminal. A CPU of the microprocessor integrated circuit is operative for executing a decoding algorithm for processing image data in the memory for attempting to decode at least one symbol represented in the memory.

Abstract: An apparatus for use in decoding a bar code symbol may include an image sensor integrated circuit having a plurality of pixels, timing and control circuitry for controlling an image sensor, gain circuitry for controlling gain, and analog to digital conversion circuitry for conversion of an analog signal to a digital signal. The apparatus may also include a printed circuit board for receiving the image sensor integrated circuit. The connection between the image sensor integrated circuit and the printed circuit board characterized by a plurality of conductive adhesive connectors disposed between a plurality of electrode pads and a plurality of contact pads, where the conductive adhesive connectors provide electrical input/output and mechanical connections between the image sensor integrated circuit and the printed circuit board. The apparatus may be operative for processing image signals generated by the image sensor integrated circuit for attempting to decode the bar code symbol.

Abstract: An encoded information reading (EIR) terminal can comprise a microprocessor communicatively coupled to a system bus, a memory, a communication interface, and a pluggable imaging assembly identified by a type identifier and configured to acquire an image comprising decodable indicia. The imaging assembly can comprise a two-dimensional image sensor configured to output an analog signal representative of the light reflected by an object located within the field of view of the imaging assembly. The EIR terminal can be configured to output, by processing the analog signal, the raw image data derived from the analog signal and/or a decoded message corresponding to the decodable indicia. The imaging assembly can be communicatively coupled to the system bus via an imaging assembly interface comprising a plurality of wires and a multi-pin connector. The imaging assembly interface can comprise one or more wires configured to carry the imaging assembly type identifier.

Abstract: An apparatus for use in decoding a bar code symbol includes a first integrated circuit chip with a wafer level camera, at least one light source, and a plurality of contact pads on a surface of the chip and a second integrated circuit chip with a processor, memory, plurality of contact pads on a surface of the chip, and plurality of contact pads on another surface of the chip. The apparatus includes a PCB having a plurality of contact pads disposed on at least one surface of the PCB and wherein the first and second integrated circuit chips are vertically stacked on the PCB and the plurality of contact pads on the first and second integrated circuit chips interface with the contact pads of the second integrated circuit chip and PCB. The apparatus is operative for processing image signals generated by the WLC for attempting to decode the bar code symbol.

Abstract: An encoded information reading (EIR) terminal can comprise a microprocessor communicatively coupled to a system bus, a memory, a communication interface, and a pluggable imaging assembly identified by a type identifier and configured to acquire an image comprising decodable indicia. The imaging assembly can comprise a two-dimensional image sensor configured to output an analog signal representative of the light reflected by an object located within the field of view of the imaging assembly. The EIR terminal can be configured to output, by processing the analog signal, the raw image data derived from the analog signal and/or a decoded message corresponding to the decodable indicia. The imaging assembly can be communicatively coupled to the system bus via an imaging assembly interface comprising a plurality of wires and a multi-pin connector. The imaging assembly inter face can comprise one or more wires configured to carry the imaging assembly type identifier.

Abstract: The disclosure provides a method for immunotherapy of a cancer patient, comprises administering to the patient an Ab that inhibits signaling from the PD-1/PD-L1 signaling pathway, or a combination of such Ab and an anti-CTLA-4 Ab. This disclosure also provides a method for immunotherapy of a cancer patient comprising selecting a patient who is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the patient that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering an anti-PD-1 Ab to the selected subject. The disclosure additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Abstract: An apparatus for use in decoding a bar code symbol may include an image sensor integrated circuit having a plurality of pixels, timing and control circuitry for controlling an image sensor, gain circuitry for controlling gain, and analog to digital conversion circuitry for conversion of an analog signal to a digital signal. The apparatus may also include a printed circuit board for receiving the image sensor integrated circuit. The connection between the image sensor integrated circuit and the printed circuit board characterized by a plurality of conductive adhesive connectors disposed between a plurality of electrode pads and a plurality of contact pads, where the conductive adhesive connectors provide electrical input/output and mechanical connections between the image sensor integrated circuit and the printed circuit board. The apparatus may be operative for processing image signals generated by the image sensor integrated circuit for attempting to decode the bar code symbol.

Abstract: There is set forth herein an indicia reading terminal having data format conversion capabilities. The indicia reading terminal includes an image sensor integrated circuit with an image sensor array comprising a plurality of pixels. The image sensor integrated circuit is configured to output image data in a first data format to a data formatting circuit for conversion to image data in a second data format. The data formatting circuit is configured to provide the image data in the second data format to the at least one data interface of a microprocessor integrated circuit, which is operative to transfer image data received by the at least one data interface into memory of the indicia reading terminal. A CPU of the microprocessor integrated circuit is operative for executing a decoding algorithm for processing image data in the memory for attempting to decode at least one symbol represented in the memory.

Abstract: An apparatus for use in decoding a bar code symbol includes a first integrated circuit chip with a wafer level camera, at least one light source, and a plurality of contact pads on a surface of the chip and a second integrated circuit chip with a processor, memory, plurality of contact pads on a surface of the chip, and plurality of contact pads on another surface of the chip. The apparatus includes a PCB having a plurality of contact pads disposed on at least one surface of the PCB and wherein the first and second integrated circuit chips are vertically stacked on the PCB and the plurality of contact pads on the first and second integrated circuit chips interface with the contact pads of the second integrated circuit chip and PCB. The apparatus is operative for processing image signals generated by the WLC for attempting to decode the bar code symbol.

Abstract: An encoded information reading (EIR) terminal can comprise a microprocessor, a communication interface, an image processing circuit communicatively coupled to the microprocessor, a plurality of imaging assemblies communicatively coupled to the image processing circuit, and one or more memory blocks communicatively coupled to the image processing circuit. Each imaging assembly of the plurality of imaging assemblies can be configured to output image frame data. The image processing circuit can be configured to receive the image frame data from at least one imaging assembly, buffer the image frame data received from at least one imaging assembly in at least one memory block, and/or process the image frame data received from at least one imaging assembly. The EIR terminal can be configured to output image frame data comprising decodable indicia and/or decoded message data corresponding to the decodable indicia.

Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Abstract: A multi-stage laser beam despeckling device including a first laser beam despeckling module for optically multiplexing an input laser beam into a temporal/spatial coherence-reduced output laser beam; and a second laser beam despeckling module, optically coupled to the first laser beam despeckling module, for receiving the temporal/spatial coherence-reduced as an input laser beam to the second despeckling module and producing a further temporal/spatial coherence-reduced output laser beam.

Abstract: Digital image capture and processing systems and methods for generating and projecting coplanar illumination and imaging planes and/or coextensive area-type illumination and imaging zones, through one or more imaging windows, and into a 3D imaging volume in a retail POS environments, while employing automatic object motion and/or velocity detection, real-time image analysis and other techniques to capture and processing high-quality digital images of objects passing through the 3D imaging volume, and intelligently controlling and/or managing the use of visible and invisible forms of illumination, during object illumination and imaging operations, that might otherwise annoy or disturb human operators and/or customers working and/or shopping in such retail environments.

Abstract: A tunnel-type digital imaging-based self-checkout system capable of generating and projecting coplanar illumination and imaging planes into a 3D imaging volume within a tunnel structure. The tunnel structure is supported above a package conveyor in a retail POS environment, and employs automatic package identification, profiling and tracking techniques during self-checkout operations.

Abstract: A POS-based digital image capturing and processing system for illuminating objects using automatic object detection and spectral-mixing illumination technique. The system comprises an area-type illumination and imaging station for projecting a coextensive area-type illumination and imaging field (i.e. zone) into a 3D imaging volume during object illumination and imaging operations. The area-type illumination and imaging station includes an illumination subsystem for producing a first field of visible illumination from an array of visible LEDs, and producing a second field of invisible illumination from an array of infrared (IR) LEDs. wherein the first and second fields of illumination spatially overlap and intermix with each other and are substantially coextensive with the FOV of the image sensing array.

Abstract: A digital image capturing and processing system for automatically recognizing objects in a POS environment. The system includes a system housing having an imaging window; illumination and imaging stations for generating and projecting illumination and imaging planes or zones through the imaging window, and into a 3D imaging volume definable relative to the imaging window, for digital imaging an object passing through the 3D imaging volume, and generating digital linear images of the object as the object intersects the illumination and imaging planes or zones during system operation. A digital image processor processes the digital images and automatically recognizes the object, such as produce and fruit, graphically represented by the digital images.