Abstract: Provided are an RNA plasmid delivery system and an application thereof. The RNA plasmid delivery system comprises a plasmid carrying an RNA fragment required to be delivered; the plasmid can be enriched in an organ tissue of a host, and spontaneously forms an exosome containing the RNA fragment in the organ tissue of the host, and therefore can enter and be combined with a target tissue to deliver the RNA fragment into the target tissue. The RNA delivery system is safe, reliable, good in druggability, and strong in universality.

Abstract: Provided are a gene circuit, an RNA delivery system and the use thereof. Specifically, the gene circuit comprises at least an RNA fragment capable of inhibiting gene expression and/or a targeting tag having a targeting function. The gene circuit can be delivered to a host, enriched in organ tissues of the host and self-assembled to form a complex structure, and inhibits gene expression by means of the RNA fragment, thereby treating diseases. The delivery system comprises the gene circuit and a delivery carrier capable of delivering the gene circuit to organ tissues of a host for enrichment. The provided gene circuit has a targeting function and a treatment function, can quickly and accurately reach target organs and target tissues to exert a treatment effect, and is highly efficient with good results. The safety and reliability of the provided RNA delivery system are fully verified, and the RNA delivery system has good druggability, high universality, and great economic benefits and application prospects.

Abstract: Provided are a viral vector-based RNA delivery system and a use thereof. The RNA delivery system comprises a viral vector. The viral vector carries an RNA fragment needing to be delivered, and can be enriched in organ tissues of a host. In the host organ tissues, the viral vector can endogenously and spontaneously form a composite structure containing the RNA fragment. The composite structure can enter and bind to target tissues, and feed the RNA fragment into the target tissues. The viral vector has a targeting tag. The composite structure is an exosome. The viral vector RNA delivery system is safe and reliable, and has good druggability and high universality.

Abstract: An RNA delivery system for the treatment of Huntington's disease. The system comprises a viral vector, the viral vector carries RNA fragments capable of treating Huntington's disease, the viral vector is capable of enrichment in organ tissues of a host and endogenously and spontaneously forming a complex containing the RNA fragments capable of treating Huntington's disease in the organ tissues of the host, and the complex can deliver the RNA fragments into a target tissue to treat Huntington's disease. The safety and reliability of the RNA delivery system for the treatment of Huntington's disease have been fully verified. The system has good medicinal properties, strong versatility, and has economic benefits and application prospects.

Abstract: A detection device includes a frame, a transport mechanism, detection mechanisms, and a grasping mechanism. The transport mechanism includes a feeding line, a first flow line, and a second flow line arranged in parallel on the frame. The detection mechanisms are arranged on the frame and located on two sides of the transport mechanism. The grasping mechanism is arranged on the frame and used to transport workpieces on the feeding line to the detection mechanisms, transport qualified workpieces to the first flow line, and transport unqualified workpieces to the second flow line.

Abstract: The process converts ethylene in a dilute ethylene (dry gas) stream that may be derived from an FCC product to propylene. The process includes an oligomerization step to convert ethylene in the dilute ethylene stream to heavier olefins, and a second reaction step to convert the heavier olefins to propylene. The oligomerization catalyst may be an amorphous silica-alumina base with a Group VIII and/or VIB metal. The catalyst is resistant to feed impurities such as hydrogen sulfide, carbon oxides, hydrogen and ammonia. At least 50 wt-% of the ethylene in the dilute ethylene stream can be converted to C4+ olefins and recycled to the FCC for cracking to propylene.

Abstract: A location-aware electronic device is provided. The electronic device trains feature extraction layers, reconstruction layers, and classification layers. The training may be based on a reconstruction loss and/or a clustering loss. The electronic device processes a fingerprint to obtain an augmented fingerprint using randomization based on statistics of the fingerprint. The feature extraction layers provide feature data to both the reconstruction layers and the classification layers. The classification layers operate on the codes to obtain an estimated location label. An application processor operates on the estimated location label to provide a location-aware application result to a person.

Abstract: A fingerprint unlocking method and a terminal are provided. The method may be applied to a terminal having an in-screen fingerprint detection function. When the terminal is in a screen-locked state, the terminal determines whether an operation of a user meets a preset condition. If the operation of the user meets the preset condition, a fingerprint recognition identifier is displayed on a touch display screen of the terminal. A display area of the fingerprint recognition identifier is an area in which fingerprint recognition can be performed. The method resolves a problem that the user cannot perform fingerprint unlocking because the user cannot see a position of a fingerprint detector.

Abstract: In one example, an eyepiece has a one-piece shape that is solid and rotationally asymmetric. The eyepiece includes first, second and third surfaces at least partially defining the one-piece shape. The first surface is configured to receive a spatially modulated light beam. The second surface is configured to internally reflect the spatially modulated light beam toward the third surface. The third surface is configured to reflect the spatially modulated light beam toward and through the second surface. Transmission of the spatially modulated light beam through the second surface concentrates the spatially modulated light beam.

Abstract: Various of the disclosed embodiments provide Graphical User Interfaces (GUIs) for reviewing prior surgical procedures. Specifically, the GUI may allow a user, such as surgeon, to review sensor data, including video data, acquired during various of the surgeon's past surgical procedures. Some sensor data may be organized into metrics referred to herein as objective performance indicators (OPIs). Similarly, procedures may be discretized into specific tasks. By organizing and presenting data in OPI form at the task level, the GUI may facilitate efficient and coordinated review of the surgeon's progress over time across multiple procedures. In some embodiments, corresponding data from expert surgeons may also presented in the interface so that the user may gauge the surgeon's relative performance.

Abstract: This application provides a communication method and apparatus. The communication method includes: receiving measurement configuration information from a network device, where the measurement configuration information is used to configure a channel measurement resource and M interference measurement resources, and M is a positive integer greater than or equal to 1; and sending a bitmap to the network device, where the bitmap includes one or more bits, each bit corresponds to one or more interference measurement resources and has a value indicating interference of the one or more interference measurement resources to the channel measurement resource, and the M interference measurement resources include the one or more interference measurement resources.

Abstract: Compositions and methods are provided for simple, instrument-free and sensitive methods that enable rapid, point-of-care detection of nucleic acid molecules of interest. This is based on a surprising discovery that the relative efficiencies of amplification and CRISPR-based cleavage and detection can be tuned to favor amplification until sufficient amplified products are generated to enable detection. Example approaches include design of guide RNA and primers to target nonoptimal PAM sequences, or sequence-engineering Cas nucleases to reduce activities informing a ribonucleoprotein with the guide RNA or binding to or cleaving the substrate nucleic acid.

Abstract: A first device is logged in with a first user account. The first device displays an avatar of a second user account in a first user interface of the first device. In response to an interaction instruction triggered on the avatar of the second user account, the first device generates an interaction message according to a first field corresponding to the first user account, an action description field corresponding to the interaction instruction, and a second field corresponding to the second user account. The first device transmits the interaction message to a second device that is logged in with the second user account.

Abstract: A terminal structure of a bidirectional switching device, where the terminal structure can include: a field plate located on a top surface of a well region and between a first voltage-withstand region and a second voltage-withstand region, where the bidirectional switching device comprises the well region, and the first and second voltage-withstand regions located in the well region; and where a potential is connected to the field plate, in order to decrease an electrical leakage of a parasitic transistor, where the parasitic transistor is formed by the first voltage-withstand region, the well region, and the second voltage-withstand region.

Abstract: A system includes a color filter including a first segment configured to transmit first light having a first color and to reflect second light having a second color and a second segment configured to transmit the second light having the second color and to reflect the first light having the first color. The system also includes an integrator rod optically coupled to the color filter, a reflective surface having an aperture on an end of the integrator rod.

Abstract: A system having a color filter having first and second segments. The first and second segments allow respective first and second wavelengths to pass through to a spatial light modulator. The first and second segments also reflect second and first wavelengths, respectively. The reflected first and second wavelengths are recycled and directed towards the color filter.

Abstract: An apparatus includes a light source configured to produce light and a prism. The apparatus also includes freeform optics optically coupled between the light source and the prism, the freeform optics configured to direct the light towards the prism and eyepiece optics optically coupled to the prism. Additionally, the apparatus includes a spatial light modulator (SLM) optically coupled to the prism, the prism configured to direct the light towards the SLM, the SLM configured to modulate the light to produce modulated light, and the prism configured to direct the modulated light towards the eyepiece optics.

Abstract: Provided are a series of polypeptides with antiviral activity. The present invention provides a new strategy for preventing and controlling Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses and provides a new theoretical basis for accelerating the research and development of a polypeptide small molecule drug against Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses.

Abstract: An apparatus for a near eye display includes an optical waveguide coupler adapted to be optically coupled to one or more light sources, a first prism optically coupled to the optical waveguide coupler, a second prism coupled to the first prism where the first prism faces a first side of the second prism, a spatial light modulator (SLM) optically coupled to the second prism where the SLM faces a second side of the second prism, and focusing optics optically coupled to the second prism where the focusing optics face a third side of the second prism.

Abstract: A picture annotation method, includes: converting, into a video image, multiple pictures in a set of pictures to be annotated; performing video annotation on the video image to obtain an annotation result; and using the obtained annotation result as an annotation result of each picture in the set of pictures to be annotated according to a correspondence between a video frame in the video image and a picture in the set of pictures to be annotated.