Patents by Inventor Xia Cao

Xia Cao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220144966
    Abstract: The present disclosure provides anti-CD38 antigen-binding proteins such as fully human anti-CD38 IgG class antibodies each having an altered amino acid sequence in their heavy chain variable region and/or light chain variable region compared to their wild type parent antibody. The present disclosure provides engineered CD38 binding proteins, particularly anti-CD38 variant antibodies, or antigen-binding portions thereof, that specifically bind CD38, and uses thereof. The disclosed anti-CD38 antigen-binding proteins and antibodies have been engineered to exhibit improved characteristics compared to the parent antibody, such as improved binding to CD38 antigen, improved binding to CD38-expressing cells, and/or higher levels of cytotoxicity. The anti-CD38 variant antibodies can cross-react (bind) with cynomolgus CD38.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 12, 2022
    Applicant: Sorrento Therapeutics, Inc.
    Inventors: Xia Cao, Heyue Zhou, John Dixon Gray, Barbara A. Swanson
  • Publication number: 20220115706
    Abstract: Electrolytes for lithium ion batteries with carbon-based, silicon-based, or carbon- and silicon-based anodes include a lithium salt; a nonaqueous solvent comprising at least one of the following components: (i) an ester, (ii) a sulfur-containing solvent, (iii) a phosphorus-containing solvent, (iv) an ether, (v) a nitrile, or any combination thereof, wherein the lithium salt is soluble in the solvent; a diluent comprising a fluoroalkyl ether, a fluorinated orthoformate, a fluorinated carbonate, a fluorinated borate, a fluorinated phosphate, a fluorinated phosphite, or any combination thereof, wherein the lithium salt has a solubility in the diluent at least 10 times less than a solubility of the lithium salt in the solvent; and an additive having a different composition than the lithium salt, a different composition than the solvent, and a different composition than the diluent. In some electrolytes, the nonaqueous solvent comprises an ester.
    Type: Application
    Filed: November 29, 2021
    Publication date: April 14, 2022
    Applicant: Battelle Memorial Institute
    Inventors: Xia Cao, Ji-Guang Zhang, Wu Xu
  • Patent number: 11242751
    Abstract: Disclosed are methods, compositions, and composition packages for spray-coating a membrane for waterproofing a concrete tunnel applications. After primer coating is applied onto a surface in the tunnel, the coating composition is sprayed to form a membrane, and then concrete is cast or sprayed against the membrane so that it can bond to the membrane. Coating compositions comprise two or more acrylate monomers, as well as initiator, accelerator, and optional additive. Preferably, the coating composition is established by using a two-part package, one part having initiator, the other part having accelerator, and each part containing the monomers and optional additives so that the two parts can be shipped to the application site and mixed in a 1:1 ratio during spraying. The waterproofing coating composition provides excellent bonding with concrete.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: February 8, 2022
    Inventors: David Cozzens, Xia Cao, Steven Horton, Rachel C. Weston, Abbas Kazmi
  • Publication number: 20220025643
    Abstract: A membrane(10) for waterproofing a substrate and a method for waterproofing a substrate using the membrane (10), where the membrane (10) comprising a laminate construction wherein the laminate comprises a carrier sheet (12), a pressure-sensitive adhesive (PSA) layer (14), a particulate layer (16) partially embedded into the PSA layer (14), and a protective top-coating layer (18) attached to the particulate layer (16), the laminate having parallel side edges whereby the laminate construction can be rolled into a roll form along the side edges for shipment.
    Type: Application
    Filed: December 11, 2018
    Publication date: January 27, 2022
    Inventors: Huhe CHEN, Hongmei DING, Robert A. Wiercinski, Xia Cao, Jyoti Seth
  • Publication number: 20210406466
    Abstract: A computer-implemented method, system, and computer program product for identifying requirements in a document. A document including requirements is received. Attribute related information in the document is identified using an attribute model. Component information in the document is identified using a component model. The attribute related information and the component information identified in the document are merged. Requirements in the document are identified from the merged attribute related information and component information. The requirements identified in the document are used to develop a product.
    Type: Application
    Filed: June 30, 2020
    Publication date: December 30, 2021
    Inventors: Wan Wan Miao, Sheng Hui Zhan, Zhi Lin Hu, Shu Xia Cao, Jian Hui Chen, Tao Liu
  • Publication number: 20210388097
    Abstract: The present disclosure provides BCMA binding proteins, particularly anti-BCMA antibodies, or antigen-binding portions thereof, that specifically bind BCMA and uses thereof. In one embodiment, the anti-BCMA antibody comprises an antigen binding portion that binds a human BCMA epitope and blocks binding (e.g, inhibits binding) of human APRIL and/or human BAFF to the human BCMA epitope. Various aspects of the anti-BCMA antibodies relate to antibody fragments, single-chain antibodies, pharmaceutical compositions, nucleic acids, recombinant expression vectors, host cells, and methods for preparing and using such anti-BCMA antibodies. Methods for using the anti-BCMA antibodies include in vitro and in vivo methods for binding BCMA, detecting BCMA and treating diseases associated with BCMA over-expression.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 16, 2021
    Applicant: Sorrento Therapeutics, Inc.
    Inventors: Heyue Zhou, Xia Cao
  • Publication number: 20210340762
    Abstract: The present invention provides a panel sheathing for making wall and roof structures in which the panels (e.g., wood boards, oriented strand boards, plywood, etc.) are pre-coated at a factory, before installation at the building/construction site, using a polymeric barrier coating having specific water permeability, self-sealing properties with respect to penetrated metal fasteners (e.g., nails) in accordance with ASTM D7349 (modified using 1.5-5.0 inches water depth in hydrostatic head testing over sample of coated panel in which a steel nail is driven to within ? inches of being flush with the panel and conditioning the test specimen for 24 hours at 23° C. prior to hydrostatic loading), as well as anti-blocking properties whereby the coated panels can be transported in stacked configuration without sticking or disintegration of the polymeric barrier coating.
    Type: Application
    Filed: August 14, 2018
    Publication date: November 4, 2021
    Inventors: Anandakumar RANGANATHAN, Robert A. WIERCINSKI, Xia CAO, Marysusan COUTURIER, MD Nasim HYDER, Jyoti SETH, Nicholas PANKEWYTCH
  • Publication number: 20210246786
    Abstract: Disclosed are methods, compositions, and composition packages for spray-coating a membrane for waterproofing a concrete tunnel applications. After primer coating is applied onto a surface in the tunnel, the coating composition is sprayed to form a membrane, and then concrete is cast or sprayed against the membrane so that it can bond to the membrane. Coating compositions comprise two or more acrylate monomers, as well as initiator, accelerator, and optional additive. Preferably, the coating composition is established by using a two-part package, one part having initiator, the other part having accelerator, and each part containing the monomers and optional additives so that the two parts can be shipped to the application site and mixed in a 1:1 ratio during spraying. The waterproofing coating composition provides excellent bonding with concrete.
    Type: Application
    Filed: April 27, 2021
    Publication date: August 12, 2021
    Inventors: David Cozzens, Xia Cao, Steven Horton, Rachel C. Weston, Abbas Kazmi
  • Publication number: 20210218062
    Abstract: Electrolytes for lithium ion batteries with carbon-based, silicon-based, or carbon- and silicon-based anodes include a lithium salt; a nonaqueous solvent comprising at least one of the following components: (i) an ester, (ii) a sulfur-containing solvent, (iii) a phosphorus-containing solvent, (iv) an ether, (v) a nitrile, or any combination thereof, wherein the lithium salt is soluble in the solvent; a diluent comprising a fluoroalkyl ether, a fluorinated orthoformate, a fluorinated carbonate, a fluorinated borate, or a combination thereof, wherein the lithium salt has a solubility in the diluent at least 10 times less than a solubility of the lithium salt in the solvent; and an additive having a different composition than the lithium salt, a different composition than the solvent, and a different composition than the diluent.
    Type: Application
    Filed: January 8, 2021
    Publication date: July 15, 2021
    Applicant: Battelle Memorial Institute
    Inventors: Wu Xu, Ji-Guang Zhang, Hao Jia, Xianhui Zhang, Xia Cao, Sujong Chae, Ran Yi, Qiuyan Li, Won-Jin Kwak, Xiaolin Li
  • Publication number: 20210209500
    Abstract: Aspects of the present disclosure describe techniques for generating a machine learning model for extracting information from textual content. The method generally includes receiving a training data set including a plurality of documents having related textual strings. A relevancy model is generated from the training data set. The relevancy model is generally configured to generate relevance scores for a plurality of words extracted from the plurality of documents. A knowledge graph model illustrating relationships between the plurality of words extracted from the plurality of documents is generated from the training data set. The relevancy model and the knowledge graph model are aggregated into a complimentary model including a plurality of nodes from the knowledge graph model and weights associated with edges between connected nodes, wherein the weights comprise relevance scores generated from the relevancy model, and the complimentary model is deployed for use in analyzing documents.
    Type: Application
    Filed: January 3, 2020
    Publication date: July 8, 2021
    Inventors: Zhi Lin Hu, Wan Wan Miao, Shu Xia Cao, Tao Liu, Hao Zhang
  • Publication number: 20200403273
    Abstract: One embodiment disclosed herein is an electrolyte composition comprising: an active salt; and a solvent portion that comprises at least 10 vol. % of at least one orthoformate or a mixture of orthoformates, based on the total volume of the solvent portion.
    Type: Application
    Filed: June 17, 2020
    Publication date: December 24, 2020
    Applicant: Battelle Memorial Institute
    Inventors: Jiguang Zhang, Xia Cao, Wu Xu
  • Patent number: 10854923
    Abstract: Low flammability and nonflammable localized superconcentrated electrolytes (LSEs) for stable operation of lithium and sodium ion batteries are disclosed. Electrochemical devices including the low flammability and nonflammable LSEs are also disclosed. The low flammability and nonflammable LSEs include an active salt, a solvent comprising a flame retardant compound, wherein the active salt is soluble in the solvent, and a diluent in which the active salt is insoluble or poorly soluble. The LSE may further include a cosolvent, such as a carbonate, a sulfone, a sulfite, a sulfate, a carboxylate, an ether, a nitrogen-containing solvent, or any combination thereof. In certain embodiments, such as when the solvent and diluent are immiscible, the LSE further includes a bridge solvent.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: December 1, 2020
    Assignee: Battelle Memorial Institute
    Inventors: Wu Xu, Shuru Chen, Ji-Guang Zhang, Xia Cao, Haiping Jia, Bin Liu, Xiaodi Ren
  • Publication number: 20200216706
    Abstract: Disclosed are methods, compositions, and composition packages for spray-coating a membrane for waterproofing a concrete tunnel applications. After primer coating is applied onto a surface in the tunnel, the coating composition is sprayed to form a membrane, and then concrete is cast or sprayed against the membrane so that it can bond to the membrane. Coating compositions comprise two or more acrylate monomers, as well as initiator, accelerator, and optional additive. Preferably, the coating composition is established by using a two-part package, one part having initiator, the other part having accelerator, and each part containing the monomers and optional additives so that the two parts can be shipped to the application site and mixed in a 1:1 ratio during spraying. The waterproofing coating composition provides excellent bonding with concrete.
    Type: Application
    Filed: December 31, 2019
    Publication date: July 9, 2020
    Inventors: David Cozzens, Xia Cao, Steven Horton, Rachel C. Weston, Abbas Kazmi
  • Publication number: 20200161706
    Abstract: Localized superconcentrated electrolytes (LSEs) and electrochemical devices including the LSEs are disclosed. The LSE includes an active salt, a solvent in which the active salt is soluble, and a diluent in which the active salt is insoluble or poorly soluble, wherein the diluent includes a fluorinated orthoformate.
    Type: Application
    Filed: November 19, 2019
    Publication date: May 21, 2020
    Applicant: Battelle Memorial Institute
    Inventors: Xia Cao, Ji-Guang Zhang, Wu Xu
  • Publication number: 20190123390
    Abstract: Low flammability and nonflammable localized superconcentrated electrolytes (LSEs) for stable operation of lithium and sodium ion batteries are disclosed. Electrochemical devices including the low flammability and nonflammable LSEs are also disclosed. The low flammability and nonflammable LSEs include an active salt, a solvent comprising a flame retardant compound, wherein the active salt is soluble in the solvent, and a diluent in which the active salt is insoluble or poorly soluble. The LSE may further include a cosolvent, such as a carbonate, a sulfone, a sulfite, a sulfate, a carboxylate, an ether, a nitrogen-containing solvent, or any combination thereof. In certain embodiments, such as when the solvent and diluent are immiscible, the LSE further includes a bridge solvent.
    Type: Application
    Filed: August 31, 2018
    Publication date: April 25, 2019
    Inventors: Wu Xu, Shuru Chen, Ji-Guang Zhang, Xia Cao, Haiping Jia, Bin Liu, Xiaodi Ren
  • Patent number: 9476196
    Abstract: Disclosed is a waterproofing membrane that comprises a carrier sheet (layer A); a waterproofing adhesive (layer B); a protective coating (layer C), wherein the protective coating is substantially free of surfactant and comprises an acrylic or methacrylic polymer or copolymer, an inorganic filler and a white pigment; and a releasable material (layer D), wherein the releasable material comprises amorphous nanoscale silica and a polymeric binder. The waterproofing membrane does not require a release liner, binds strongly to concrete cast against it (even after UV exposure), tolerates foot traffic, and withstands immersion in water over an extended period.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: October 25, 2016
    Assignee: GCP Applied Technologies Inc.
    Inventors: Robert A. Wiercinski, Anandakumar Ranganathan, Xia Cao, Robert Paul
  • Patent number: 9394464
    Abstract: Disclosed is a waterproofing membrane that comprises a carrier sheet, a pressure sensitive adhesive layer on one surface of the carrier sheet, and a protective coating layer on the adhesive layer. The protective coating layer comprises a highly reflective protective coating layer operative to bond to concrete cast against it, particularly one that is produced from an aqueous coating comprising an acrylic emulsion, a filler, and a white pigment. The pigment volume concentration of the filler plus white pigment is greater than or equal to 40% by volume. The protective coating layer protects the membrane against weather exposure, tolerates foot traffic and strongly adheres to concrete cast against it. The protective coating comprises an acrylic polymer with a unique multi-domain morphology (i.e., at least two distinct polymer domains).
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: July 19, 2016
    Assignee: GCP Applied Technologies Inc.
    Inventors: Robert A. Wiercinski, Anandakumar Ranganathan, Xia Cao, Robert Paul
  • Patent number: 9283190
    Abstract: A high-efficacy, long-acting, slow-release formulation of the poorly soluble drug, comprising solid dispersion of the poorly soluble drug, silica nanoparticles loaded with the poorly soluble drug, matrix material, and release enhancer, wherein the mass ratio of these components is solid dispersion of the poorly soluble drug: silica nanoparticles loaded with the poorly soluble drug: matrix material: release enhancer=1: 0.5˜1.25: 0.1˜0.3: 0.1˜0.3; the said solid dispersion of the poorly soluble drug contains povidone K30, soybean lecithin, and acrylic resin IV, wherein the mass ratio of the drug and the accessory materials is poorly soluble drug: povidone K30: soybean lecithin: acrylic resin IV=1: 1˜3: 0.3˜0.8: 0.2˜0.5. Compared with the existing formulations, the in vivo half life of the high-efficacy, long-acting formulation of the poorly soluble drug disclosed in this invention is 2.3˜14.8 times longer while the mean residence time (MRT) of which is 7.94˜4.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: March 15, 2016
    Assignee: JIANGSU UNIVERSITY
    Inventors: Ximing Xu, Jiangnan Yu, Yuan Zhu, Xia Cao
  • Patent number: 9193837
    Abstract: A composite material having polymeric resin with disperse phases of reinforcing fibers and nanoparticle materials and its manufacture is disclosed herein. The nanoparticles may be bound together and added to the polymeric resin as microscale aggregations, and then unbound to create a disperse phase of nanoparticles in the resin. In other embodiments, the nanoparticles may be bound to a substrate, such as long fibers, and added to a polymeric resin. The nanoparticles are then unbound from the substrate and dispersed throughout the polymeric resin. The polymeric resin may have multiple components where one component may control the dispersion of the nanoparticles.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: November 24, 2015
    Inventors: L. James Lee, Gang Zhou, Xia Cao
  • Patent number: 9187608
    Abstract: Polymer extruded or expanded foams that contain modifier-free nanoclays are provided. The addition of modifier-free nano-clays to extruded or expanded foam products improves the thermal properties, mechanical properties, and fire performance properties. Water or a water-containing compound is used as a carrier for the modifier-free nanoclays. The final foamed products may be utilized in building application such as foamed insulation products and in underground applications such as highway insulation. A preferred modifier-free nanoclay is Na+MMT. Modifier-free nanoclay particles may be injected into a polymer during an extrusion foaming process. In another embodiment of the invention, polymer beads containing water/nanoclay particles are formed using inverse emulsion/suspension polymerizations and expanded or extruded into a foamed product. In a further embodiment, a modifier-free nanoclay particle is encapsulated in a super-absorbent material, which may be used in an expanding or extruding process.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: November 17, 2015
    Assignee: Owens Corning Intellectual Capital, LLC
    Inventors: Roland R. Loh, Mark E. Polasky, Yadollah Delaviz, L. James Lee, Xia Cao, Jiong Shen, Bharat Patel