Patents by Inventor Xia Peng

Xia Peng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10988456
    Abstract: An o-aminoheteroaryl alkynyl-containing compound has a structure represented by formula (I), and the compound of formula (I) has advantages of a high FGFR and RET double target inhibitory activity and a relatively low KDR activity, and the compound of formula (I) exhibits a strong inhibitory activity in a human lung cancer cell line NCI-H1581 and a gastric cancer cell line SNU16 as well as an RET-dependent sensitive cell line BaF3-CCDC6-Ret and a mutant thereof. Pharmacokinetic data shows that the o-aminoheteroaryl alkynyl-containing compound has druggability, and exhibits significant relevant inhibition of the growth of related tumors in a long-term animal model of drug efficacy and results in favorable animal condition at effective doses.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: April 27, 2021
    Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Youhong Hu, Meiyu Geng, Wenming Ren, Jian Ding, Xiaocong Guan, Jing Ai, Lang Wang, Xia Peng, Yang Liu, Yang Dai, Limin Zeng
  • Publication number: 20210119086
    Abstract: A light-emitting diode (LED) includes a light-transmissive substrate which has a first surface, an epitaxial structure which is disposed on the first surface, a first insulation layer, and a second insulation layer. The epitaxial structure has an upper surface opposite to the first surface, and a side wall interconnecting the upper surface and the first surface. The first insulation layer covers the side wall and the upper surface. The second insulation layer covers a portion of the first surface that is not covered by the epitaxial structure and the first insulation layer, and has a light transmittance greater than that of the first insulation layer. An LED package, an LED module, and a display device including the LEDs are also disclosed.
    Type: Application
    Filed: October 16, 2020
    Publication date: April 22, 2021
    Inventors: Feng WANG, Zhanggen XIA, Yu ZHAN, En-song NIE, Anhe HE, Kang-Wei PENG, Su-Hui LIN
  • Publication number: 20210078972
    Abstract: The present invention relates to quinoline or quinazoline compound represented by the formula (I), a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a prodrug molecule thereof, or a deuterated compound thereof. The compound of the present invention is effective in inhibiting the action of AXL protein kinase and can inhibit proliferation, migration, and invasion of various tumor cells. Further, the quinoline or quinazoline compound of the present invention has excellent metabolic stability, high in vivo antitumor activity, low toxic side effects, and can be used for preparing a drug for preventing hyperproliferative diseases such as tumors in humans and other mammals.
    Type: Application
    Filed: March 29, 2019
    Publication date: March 18, 2021
    Inventors: Ke DING, Meiyu GENG, Shingpan CHAN, Jian DING, Li TAN, Jing AI, Zhang ZHANG, Xia PENG, Xiaomei REN, Yinchun JI, Zhengchao TU, Yang DAI, Xiaoyun LU
  • Publication number: 20200172510
    Abstract: Provided in the present invention are a substituted amino six-membered nitric heterocyclic ring compound and a preparation and use thereof. In particular, provided in the present invention is a compound as shown by general formula (I) below, wherein the definition of each group is as described in the description. The compound of the present invention has an excellent tyrosine kinase inhibitory activity, and can thus be used to prepare a series of medicines for treating diseases related to tyrosine kinase inhibitory activity.
    Type: Application
    Filed: February 17, 2017
    Publication date: June 4, 2020
    Inventors: Ao ZHANG, Meiyu GENG, Li XING, Jing AI, Zilan SONG, Xia PENG, Wangting GU, Jian DING
  • Publication number: 20200060970
    Abstract: Provided are an exosome preparation formed by secretion by a mast cell cultured in vitro, a preparation method of an exosome therein, an exosome containing Fc?RI protein on an outer surface thereof and in a substantially unbound state, and uses of the exosome preparation or exosome in a method for inhibiting mast cell activation in vitro and in preparing a drug for treating an IgE-mediated disease.
    Type: Application
    Filed: December 15, 2017
    Publication date: February 27, 2020
    Inventors: Li Li, Xia Peng, Guogang Xie
  • Publication number: 20200055838
    Abstract: An o-aminoheteroaryl alkynyl-containing compound has a structure represented by formula (I), and the compound of formula (I) has advantages of a high FGFR and RET double target inhibitory activity and a relatively low KDR activity, and the compound of formula (I) exhibits a strong inhibitory activity in a human lung cancer cell line NCI-H1581 and a gastric cancer cell line SNU16 as well as an RET-dependent sensitive cell line BaF3-CCDC6-Ret and a mutant thereof. Pharmacokinetic data shows that the o-aminoheteroaryl alkynyl-containing compound has druggability, and exhibits significant relevant inhibition of the growth of related tumors in a long-term animal model of drug efficacy and results in favorable animal condition at effective doses.
    Type: Application
    Filed: February 12, 2018
    Publication date: February 20, 2020
    Inventors: Youhong HU, Meiyu GENG, Wenming REN, Jian DING, Xiaocong GUAN, Jing AI, Lang WANG, Xia PENG, Yang LIU, Yang DAI, Limin ZENG
  • Publication number: 20190135818
    Abstract: The present invention provides a compound comprising a 5-membered heterocycle fused with a pyridazinone, wherein the compound is used as an FGFR kinase inhibitor, and a manufacturing method and application thereof. The invention specifically provides a compound as represented by formula (I). Various radicals are as defined in the specification. The compound provided by the invention effectively inhibits an activity of an FGFR kinase, and can be used to manufacture a pharmaceutical product for treating a disease related to the activity of the FGFR kinase.
    Type: Application
    Filed: May 24, 2017
    Publication date: May 9, 2019
    Inventors: Hualiang JIANG, Hong LIU, Meiyu GENG, Mingyue ZHENG, Jing AI, Yulan WANG, Xiaowei WU, Shuangjie LI, Xia PENG, Chunpu LI, Kaixian CHEN, Bao WANG
  • Patent number: 9988381
    Abstract: This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumors associated with abnormal protein tyrosine kinase.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: June 5, 2018
    Assignees: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai Haihe Pharmaceutical Co., Ltd.
    Inventors: Jingkang Shen, Meiyu Geng, Jian Ding, Bing Xiong, Jing Al, Yuchi Ma, Xin Wang, Xia Peng, Yuelei Chen, Danqi Chen, Tao Meng, Lanping Ma, Yinchun Ji
  • Patent number: 9567342
    Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: February 14, 2017
    Assignees: SHANGHAI FOCHON PHARMACEUTICAL CO., LTD., SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES
    Inventors: Weibo Wang, Meiyu Geng, Jian Ding, Xingdong Zhao, Jing Ai, Qiang Tian, Xia Peng, Weipeng Zhang, Hongbin Liu, Haohan Tan, Ling Chen
  • Publication number: 20160145244
    Abstract: Provided are certain ALK inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
    Type: Application
    Filed: November 19, 2015
    Publication date: May 26, 2016
    Applicant: FOCHON PHARMA, INC.
    Inventors: Weibo Wang, Meiyu Geng, Jian Ding, Xingdong Zhao, Jing Ai, Huajie Zhang, Xia Peng
  • Publication number: 20160137640
    Abstract: This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumours associated with abnormal protein tyrosine kinase.
    Type: Application
    Filed: June 18, 2014
    Publication date: May 19, 2016
    Inventors: Jingkang Shen, Meiyu Geng, Jian Ding, Bing Xiong, Jing Al, Yuchi Ma, Xin Wang, Xia Peng, Yuelei Chen, Danqi Chen, Tao Meng, Lanping Ma, Yinchun Ji
  • Publication number: 20160046638
    Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.
    Type: Application
    Filed: October 29, 2015
    Publication date: February 18, 2016
    Inventors: Weibo WANG, Meiyu GENG, Jian DING, Xingdong ZHAO, Jing AI, Qiang TIAN, Xia PENG, Weipeng ZHANG, Hongbin LIU, Haohan TAN, Ling CHEN
  • Patent number: 9206166
    Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: December 8, 2015
    Assignees: Shanghai Institute of Materia Medica Academy of Sciences, Shanghai Fochon Pharmaceutical Co., LTD
    Inventors: Weibo Wang, Meiyu Geng, Jian Ding, Xingdong Zhao, Jing Ai, Qiang Tian, Xia Peng, Weipeng Zhang, Hongbin Liu, Haohan Tan, Ling Chen
  • Patent number: 9187635
    Abstract: A halogen-free resin composition includes (A) 100 parts by weight of epoxy resin; (B) 10 to 100 parts by weight of styrene-maleic anhydride (SMA) copolymer; and (C) 5 to 50 parts by weight of bisphenol S. The halogen-free resin composition includes specific ingredients, and is characterized by specific proportions thereof, to thereby achieve a high glass transition temperature, high heat resistance, and attractive appearance, and thus is suitable for producing a prepreg or resin film to thereby be applicable to copper clad laminates and printed circuit boards.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: November 17, 2015
    Assignee: ELITE ELECTRONIC MATERIAL (ZHONGSHAN) CO., LTD.
    Inventors: Chang-Yuan Li, Yi-Jen Chen, Hong-Xia Peng
  • Patent number: 9185801
    Abstract: A halogen-free resin composition includes (A) 100 parts by weight of epoxy resin; (B) 2 to 15 parts by weight of oxydianiline (ODA); and (C) 2 to 20 parts by weight of amino triazine novolac (ATN) resin. The halogen-free resin composition includes specific ingredients, and is characterized by specific proportions thereof, to thereby achieve a low dielectric constant, a low dielectric dissipation factor, high heat resistance, and high flame retardation, and thus is suitable for producing a prepreg or resin film to thereby be applicable to copper clad laminates and printed circuit boards.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 10, 2015
    Assignee: ELITE ELECTRONIC MATERIAL (ZHONGSHAN) CO., LTD
    Inventors: Chang-Yuan Li, Li-Chih Yu, Hong-Xia Peng
  • Patent number: 9182846
    Abstract: A touch input control method comprising steps is provided: displaying an interface comprising at least one object; gathering signals as to actual touches for calibration purposes. In use, calculating coordinates of the touch; determining whether the coordinates of the actual touch match the predetermined touch coordinates of the object; creating an adjustment signal if the coordinates of the touch is not the same as the predetermined touch coordinates of any object; determining which finger used for touch input, and retrieving a touch offset direction and a touch offset distance of the determined finger of the user from a calibration database; and applying compensation to the coordinates of the touch, so as to determine the touched object. An electronic device using the touch input control method is also provided.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: November 10, 2015
    Assignees: Fu Tai Hua Industry (Shenzhen) Co., Ltd., HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Li-Xia Peng, Zhang-Yong Zheng, Fei Wang, Xue-Shun Liu, Xin Lu, Huan-Huan Zhang
  • Publication number: 20140128387
    Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 8, 2014
    Applicants: SHANGHAI iNSTITUTE OF MATERIA MEDICA ACADEMY OF SCIENCES, SHANGHAI FOCHON PHARMACEUTICAL CO., LTD.
    Inventors: Weibo WANG, Meiyu Geng, Jian Ding, Xingdong Zhao, Jing Ai, Qiang Tian, Xia Peng, Weipeng Zhang, Hongbin Liu, Haohan Tan, Ling Chen
  • Publication number: 20120066532
    Abstract: An electronic device includes a dynamic memory, a static memory, a detection unit, a copy unit and a set unit. The dynamic memory stores an interrupt monitoring program. The interrupt monitoring program monitors whether an interrupt request is generated, and generates an interrupt signal when the interrupt request is generated. The detection unit detects whether the electronic device needs to enter a sleep mode, and generates a detection signal if the electronic device needs to enter the sleep mode. The copy unit copies the interrupt monitoring program from the dynamic memory to the static memory in response to the detection signal, and runs the interrupt monitoring program in the static memory for monitoring whether an interrupt signal is generated. The set unit sets the dynamic memory into a self-refresh mode in response to the detection signal.
    Type: Application
    Filed: March 16, 2011
    Publication date: March 15, 2012
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., FU TAI HUA INDUSTRY (SHENZHEN) CO., LTD.
    Inventors: SHIH-FANG WONG, XIN LU, XUE-SHUN LIU, JUN-JIE LI, BIAO-GENG ZHONG, HUAN-HUAN ZHANG, DAN WANG, BI-QING LUO, FEI WANG, LI-XIA PENG
  • Publication number: 20120049654
    Abstract: An electronic device is provided. The electronic device is connected to an external power supply through an interface. The electronic device comprises a processing unit and an input unit. The input unit responds to a power off operation to generate a power off signal and sends the power off signal to the processing unit. The processing unit periodically checks whether the electronic device is disconnected from the external power supply after receiving the power off signal, and powers off the electronic device if the electronic device is disconnected from the external power supply.
    Type: Application
    Filed: October 24, 2010
    Publication date: March 1, 2012
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., FU TAI HUA INDUSTRY (SHENZHEN) CO., LTD.
    Inventors: SHIH-FANG WONG, XIN LU, HUAN-HUAN ZHANG, JUN-JIE LI, BIAO-GENG ZHONG, XUE-SHUN LIU, DAN WANG, BI-QING LUO, FEI WANG, LI-XIA PENG
  • Publication number: 20090322542
    Abstract: A system and method for ambient monitoring temperature and humidity, includes a controller, a host and an alarm device. The controller includes a sensing module and a determining module. The sensing module senses temperature and humidity. The determining module determines whether the sensed environment temperature and humidity are abnormal according to predetermined standards, and determines howl long the environment continues to be abnormal, and outputs an abnormal signal if the abnormal environment continues to be abnormal beyond a preset time limit. The host is connected to the controller, to transmit an alarm signal according to the abnormal signal. The alarm device is connected to the host, to activate according to the alarm signal.
    Type: Application
    Filed: May 6, 2009
    Publication date: December 31, 2009
    Applicants: HONG FU JIN PRECISION INDUSTRY (ShenZhen) CO., LTD., HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: HONG-LIANG DING, LI-XIA PENG, XIAO-HUI CHANG, YONG-GANG ZHANG, KUANG-YUAN CHANG