Abstract: The disclosure provides a lentiviral vector for overexpressing Epidermal Growth Factor (EGF), a recombinant stem cell containing the lentiviral vector, and use of the lentiviral vector and the recombinant stem cell containing the lentiviral vector in the preparation of a medicament for the treatment of related diseases. The lentiviral vector of the disclosure comprises a vector plasmid, wherein the vector plasmid comprises a 5?LTR containing a ? sequence, a 3?LTR, a target gene sequence between the 5?LTR and the 3?LTR, and a promoter sequence and a translation initiation sequence operably linked to the target gene sequence, and the target gene sequence is a nucleotide sequence encoding EGF.

Abstract: The reusable SERS molecular test device includes two glass sheets, wherein a noble metal nano film is deposited on the surface of one of the glass sheets to form an SERS substrate, a metal ring is formed by depositing on an edge region of the SERS substrate by means of a coating process, and the metal ring fits with the SERS substrate to form a two-dimensional air chamber; and the other glass sheet, on which molecules under test are adsorbed and immobilized, is placed upside down on the metal ring, the thickness of the layer of the molecules under test being not greater than the thickness of the metal ring. The SERS molecular test device can fundamentally prevent the SERS substrate from being irreversibly contaminated by the molecules under test, so that the SERS substrate can be used in a cleaning-free and reusable manner.

Abstract: A recombinant hybrid protein, a nucleic acid molecule encoding the recombinant hybrid protein, a transgenic expression cassette containing the nucleic acid molecule, and a gene delivery system containing the transgenic expression cassettes that can be used for treating muscular dystrophy. The nucleic acid molecule, the transgenic expression cassette and the gene delivery system can stably express a therapeutic protein in muscle tissues, so that a good therapeutic effect on muscular dystrophy is realized.

Abstract: Provided are a display panel and a display device. The display panel includes: a via hole penetrating through the display panel; a cutting residual area on the periphery of the via hole and includes a base substrate, and a packaging layer; and at least one annular relief structure between the packaging layer and the base substrate in the cutting residual area. The at least one annular relief structure is sequentially distributed around the via hole. The relief structure includes: a first titanium metal layer, an aluminum metal layer and a second titanium metal layer which are sequentially arranged in a stacked mode.

Abstract: The present disclosure relates to the technical field of die casting machine devices, in particular to a digital die casting machine with mold temperature control, including: a die casting machine configured to die-cast a casting through a mold, a cooling flow control apparatus configured to control a mold temperature by controlling a cooling medium flow, a temperature collection apparatus configured to collect the mold temperature, a control cabinet configured to acquire and store data collected by the temperature collection apparatus and control operation of the die casting machine, the cooling flow control apparatus and an automatic control apparatus, an edge computer configured to execute a die casting temperature optimization strategy according to the collected data stored in the control cabinet, and the automatic control apparatus. The present disclosure improves the molding quality of castings by adjusting the mold temperature in a casting process.

Abstract: A sulfinate glycosyl donor of formula I and a method for preparing same as well as use thereof in preparing a glycoside compound including a thioglycoside compound and a carbon glycoside compound are provided. The sulfinate glycosyl donor has a special sulfinate structure. When the sulfinate glycosyl donor is used as a raw material to prepare the glycoside compound, an additional initiator does not need to be added, such that the production cost is saved, the generation of byproducts is reduced, and the glycoside compound with a purity greater than 98% is obtained. The sulfinate glycosyl donor can be used in the preparation of the glycoside compound such as the thioglycoside compound and the carbon glycoside compound.

Abstract: A container cover relating the technical field of smart water cups is provided. The container cover includes a cover body provided with a drinking water passage, wherein an upper side of the drinking water passage is a drinking port; a cover cap provided on an upper side of the cover body; an inner cover provided on a lower side of the cover body, wherein a water outlet connected to the drinking water passage is provided in the inner cover, and a sealed accommodation cavity is formed between the inner cover and the cover body; a cover opening transducer provided between the cover body and the cover cap; and a flow sensing transducer, an orientation transducer, a power supply module, and a control circuit board provided in the sealed accommodation cavity.

Abstract: An anti-PD1 (programmed cell death 1) monoclonal antibody or an antigen-binding fragment thereof, a pharmaceutical composition thereof and use thereof. The heavy chain variable region of the monoclonal antibody comprises CDRs (complementary determining region) of amino acid sequences as shown in SEQ ID NO:9-11; and/or the light chain variable region of the monoclonal antibody comprises CDRs of amino acid sequences as shown in SEQ ID NO: 12-14. The monoclonal antibody can bind to PD1 specifically, relieve immunosuppression of PD1 on an organism specifically and activate T lymphocytes.

Abstract: A method for the glycosylation modification of proteins and/or polypeptides uses glycosyl sulfinate as a raw material. The method for glycosylation and modification is applicable not only to proteins and/or peptides containing disulfide bonds, but also to proteins and/or peptides containing sulfhydryl groups. The method is even applicable to proteins and/or peptides containing both disulfide bonds and sulfhydryl groups.

Abstract: Various embodiments for deduplication of APIs using similarity measures and artificial intelligence are described herein. An embodiment operates by receiving a request to compare a first computing program to a second computing program, wherein each computing program includes an address, one or more tables accessed by a respective computing program, one or more input parameters, and one or more output parameters. Similarity measures are calculated between the addresses, tables, input parameters, and output parameters of the two computing programs. The similarity measures are provided to a trained artificial intelligence (AI) model, which generates a similarity determination. Performed an action based on the similarity determination.

Abstract: In a method for preparing an aryl carbon glycoside compound including a gliflozin drug, a sulfinate glycosyl donor represented by formula W is used as a raw material to prepare the aryl carbon glycoside compound including the gliflozin drug. The method does not need to use an additional initiator.

Abstract: Disclosed in the present application is a hybrid automatic repeat request feedback method, which comprises the steps that: an HARQ-ACK codebook includes HARQ-ACK information of M PDSCHs, the M PDSCHs are all scheduled by first-type PDCCHs, and the first-type PDCCHs are used for activating an SPS configuration; the order of the HARQ-ACK information of the M PDSCHs in the HARQ-ACK codebook is arranged according to at least one parameter value among cell indexes, BWP indexes, SPS configuration indexes and PDSCH transmission moments of the M PDSCHs. The embodiments of the present application also provide a hybrid automatic repeat request feedback method with the participation of second-type PDCCHs for releasing SPS and dynamically configured third-type PDCCHs. The present application also provides a terminal device and a network device to which the method is applied. The present application solves the problem of how to generate an HARQ-ACK codebook when there are multiple PDSCHs in an SPS configuration condition.

Abstract: The present disclosure provides apparatus and method for blind-spot monitoring of vehicle based on rear camera. A blind spot view monitoring apparatus, for a vehicle based on a rear camera, may include an image acquisition unit, a control unit and a display unit. The image acquisition unit is configured to obtain a rear image from a rear camera mounted on a vehicle. The control unit is configured to set a region of interest in the rear image based on a turn signal or a lane departure signal of the vehicle, to determine whether there is a risk of proximity of an object in the region of interest to the vehicle, and to generate a blind spot image based on whether there is the risk of proximity. The display unit is configured to display the blind spot image.

Abstract: This application discloses a battery. The battery includes: a cabinet, the cabinet being internally provided with a chamber and the cabinet including a top surface, a bottom surface, and a plurality of side surfaces, where the top surface and the bottom surface are disposed opposite each other, the plurality of side surfaces enclose the top surface at one end, the plurality of side surfaces enclose the bottom surface at the other end, and the top surface, the bottom surface, and the plurality of side surfaces collectively form the chamber; and a plurality of battery modules, disposed in the chamber and sequentially arranged in a direction from the top surface to the bottom surface; where at least one of the plurality of side surfaces is configured to be detachable from the cabinet. The technical solution provided in this application can reduce the production costs of the battery.

Abstract: A treatment method for cerebral vasospasm involves determining amounts of let-7b-5p, miR-9-3p, miR-142-3p, miR-15b-5p, miR-17-5p, miR-19b-3p, miR-20a-5p, miR-24-3p, miR-29a-3p, miR-125b-5p, and miR-142-3p in a biological sample obtained from a subject following aneurysmal subarachnoid hemorrhage (aSAH) to identify the subject as having an elevated risk of cerebral vasospasm, and administering a treatment to the subject when the elevated risk of cerebral vasospasm is identified.

Abstract: Provided D3-binding molecules, including anti-D3antibodies, and their uses.

Abstract: Techniques described herein relate to a method for storing data in columnar storage. The method includes obtaining a columnar storage write request associated with a file, wherein the file comprises rows and columns of file data; in response to obtaining the columnar storage write request: writing the file data to storage using column-based caches; generating file metadata based on the writing of the file data to the storage; and assigning a key to the file metadata; and storing the file metadata using a key-value service.

Abstract: Recombinant Zymomonas mobilis for producing ethylene glycol, method and uses thereof are provided. The recombinant Zymomonas mobilis carries and expresses genes related to a synthesis pathway of xylonic acid and genes related to a synthesis pathway of ethylene glycol.