Abstract: An echo canceller and an echo cancellation method are provided. The echo canceller includes a self-adaptive filter, a voice signal detection portion and a path change detection portion; a far-end voice signal is propagated in an echo path through a speaker and is picked up by a microphone to form an echo signal. The self-adaptive filter is configured to receive the far-end voice signal as a training signal to simulate the echo path, and cancel the echo signal in a near-end signal. The voice signal detection portion is configured to detect a communication status, control the self-adaptive filter according to the communication status, and control startup of the path change detection portion according to the communication status. The path change detection portion is configured to detect whether a change occurs on the echo path, and control the self-adaptive filter according to whether the change occurs on the echo path.

Abstract: A papermaking process includes, firstly, providing carboxylated cellulosic fibers with a carboxyl group content being in the range from 0.06 to 1.5 mmol/g. Then the carboxylated cellulosic fibers are employed to prepare mixing pulp including filler particles, wherein the content of the carboxylated cellulosic fibers in the mixing pulp is in the range from 40% to 100% by dry fiber weight of the mixing pulp. After that, paper is made employing the mixing pulp.

Abstract: LED lighting devices/systems having air quality detection functions and methods for detecting air quality using the LED lighting devices/systems are provided. Exemplary LED lighting device includes an air quality detection unit configured to detect air quality parameter; a controller unit connected to the air quality detection unit to process data corresponding to the air quality parameter; an LED light source assembly controlled by the controller unit and configured to provide lighting; and an LED driver and power supply unit connected to drive the LED light source assembly, and to supply power to the entire LED lighting device. Exemplary LED lighting system includes at least two nodes each including an LED lighting device. By combining an air quality detection unit with an LED lighting device that are widely distributed and installed, the disclosed LED lighting devices/systems thus provide real-time and convenient air quality monitoring.

Abstract: A multifunctional LED device and multifunctional speaker system are disclosed. A multifunctional LED device consistent with the present disclosure includes a power supply unit configured to supply power; a control unit configured to process audio signals and control commands; an audio power amplifier configured to drive a speaker, a speaker configured to play audio signals, a first wireless transceiver configured to communicate with a smart terminal, a second wireless transceiver configured to communicate with other LED devices, and an LED light source. The multifunctional speaker system includes several multifunctional wireless LED devices configured to works as wireless speakers, and a smart terminal to control the system remotely. The smart terminal may communicate with and control all the multifunctional LED devices. The multifunctional LED devices may communicate with each other as well. Two of the multifunctional LED devices may be configured as a 2.0-channel speaker system.

Abstract: Embodiments consistent with the present disclosure provide a multifunctional LED device and a multifunctional speaker system. The multifunctional LED device includes a power supply unit configured to supply power; a control unit configured to process audio signals and control signals; a speaker configured to play audio signals, an audio power amplifier configured to drive the speaker, a wireless transceiver configured to receive and send data, and an LED lighting unit. Further, the wireless transceiver may communicate with both remote smart terminals and other multifunctional LED devices. The multifunctional speaker system may include several multifunctional LED devices and a smart terminal. The smart terminal may communicate with all the multifunctional LED devices. The multifunctional LED devices may communicate with each other. Two of the multifunctional LED devices may form a 2.0-channel speaker system. Other speaker systems such as 2.1-channel, 5.1-channel, 7.1-channel, speaker systems etc.

Abstract: Multifunctional LED devices and multifunctional LED wireless conference systems are provided. A multifunctional LED device includes LED light source assembly, LED drive and power supply unit, controller unit, audio power amplifier unit, microphone module, wireless transceiver module, speaker unit, and/or audio codec unit. The wireless transceiver module is configured to communicate with each of a smart terminal and a second multifunctional LED device. A multifunctional LED wireless conference system includes at least two multifunctional LED devices and at least one smart terminal to read status of and to remotely control the at least two multifunctional LED devices. The smart terminal communicates with outside terminal(s) to send audio signals from the outside terminal(s) to the multifunctional LED device(s) for broadcasting.

Abstract: A modified filler composition used in papermaking is provided. The modified filler composition contains nanofibrillated cellulose having a carboxyl content of about 0.05 to about 1.5 mmol/g, and filler having positive charge.

Abstract: Provided is a nitrogen fixation gene island suitable for expressing in prokaryotic and eukaryotic systems, wherein the prokaryotic nitrogen fixation genes are modified using T7 promoters to make them suitable for eukaryotic expression.

Abstract: An approach is provided for performing multiple and hybrid forms of communication in the same communication session. A communication manager receives a to establish a communication session using a first form of communication, wherein the communication session supports multiple and simultaneous forms of communication. Next, the communication manager selects a second form of communication to conduct the communication session. Then, the communication manager transcodes the second form of communication to the first form of communication. The different forms can be converted to facilitate and enrich the communication capability, according to an embodiment of the invention.

Abstract: The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R2, R3, R4 and R5 are defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

Abstract: The invention provides a novel class of compounds having Formula Ia, wherein each variable is as defined; and pharmaceutical compositions comprising such compounds and methods of using such compounds for inhibiting c-Src, FGFR3, KDR and/or Lck.

Abstract: An apparatus, a method, a computer program and a graphical user interface is provided.

Abstract: An apparatus, a method and a computer program is provided. The apparatus comprises at least one processor; and at least one memory storing computer program instructions, the at least one processor being configured to execute the computer program instructions to cause the apparatus at least to perform: processing an input pattern, detected at an instance in time by a touch sensitive display, to discriminate between a fingertip input pattern and an elongate input pattern; performing a first action after discriminating that the input pattern corresponds with the fingertip input pattern; and performing a second action after discriminating that the input pattern corresponds with the elongate input pattern, wherein the second action is different to the first action.

Abstract: Apparatus, a method and a computer program are provided.

Abstract: Provided are new and improved methods for detecting circulating tumor cells and tumor cell DNA in patient blood or other biofluid samples. Particular aspects comprise three steps: DNA extraction from patient samples, DNA digestion with multiple selected methylation-sensitive enzymes, and target amplification by a conventional or a real-time PCR with specific probe and/or primers. Also provided are a total of 40 tumor-specific DNA methylation loci as biomarkers having substantial utility and specificity in major types of human malignancies including hematopoietic and solid tumors.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.

Abstract: The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).

Abstract: This invention relates to 2-aza-bicyclo[2.2.1]heptane compounds (and salts thereof), the process for making such a compound and pharmaceutical compositions comprising such a compound. The invention also relates to the use of the compounds for modulating the glycine transporter 1 (GlyT1) and for the treatment of psychosis, cognitive disorders, bipolar disorders, depression disorders, anxiety disorders, post-traumatic stress disorders and pain.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).