Patents by Inventor Xia Zhao

Xia Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10316356
    Abstract: Provided is a method of constructing a sequencing library using an adaptor element in a bubble shape. The bubble-shaped adaptor is ligated to a DNA fragment respectively at the 3?-terminal and the 5?-terminal i.e., two bubble-shaped adaptors with same sequences are ligated in one step. The bubble-shaped adaptor-ligated product is then amplified with a primer complementary to the 3?-terminal of the long-chain nucleic acid of the bubble-shaped adaptor, so as to replace the non-paired sequence in the short-chain nucleic acid.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: June 11, 2019
    Assignee: MGI TECH CO., LTD.
    Inventors: Yuan Jiang, Kai Tian, Xia Zhao, Wenwei Zhang, Huaiqian Xu, Hui Jiang, Radoje Drmanac, Chunyu Geng
  • Publication number: 20190173414
    Abstract: A prediction method for reliability degree of running temperature rise of a large and medium-sized motor belongs to the technical field of reliability and durability of electromechanical power equipment, and includes determining main influence factors of the temperature rise of a motor winding, calculating the heating quantity and the temperature rise of the motor under influences of the determined factors, determining random numerical characteristics of the main influence factors of the temperature rise of the motor winding, calculating and determining possible minimum values and possible maximum values of running temperatures of the motor winding under different environment temperatures, calculating and determining reliability degrees when the running temperature of the motor winding is less than a given temperature under different environment temperatures, and calculating and determining the reliability degree of the running temperature rise of the motor winding.
    Type: Application
    Filed: January 27, 2019
    Publication date: June 6, 2019
    Inventors: Baoyun Qiu, Mengfan Xu, Xia Lu, Qiang Guo, Liming Tang, Chenglong Xue, Cai Zhang, Di Liu, Fangling Zhao
  • Publication number: 20190161468
    Abstract: It is provided herein a benzobicycloalkane derivative, and a preparation method and use thereof. In particular, it is provided herein a compound of Formula (I), or a pharmaceutically acceptable salt, stereoisomer or solvate thereof, a preparation method, and a use thereof in preparation of drugs for treating pain.
    Type: Application
    Filed: November 17, 2017
    Publication date: May 30, 2019
    Inventors: Fusheng ZHOU, Shuchun GUO, Jinzhu ZHAO, Hui XU, Xia SHI, Yi HU, Yufeng LI, Jiong LAN
  • Publication number: 20190138691
    Abstract: Systems, computer-implemented methods and/or computer program products that facilitate predicting personalized risks based on intrinsic factors and extrinsic factors are provided. In one example, a computer-implemented method comprises: collecting, by a system operatively coupled to a processor, intrinsic factors and extrinsic factors associated with infectious diseases; generating, by the system, a probabilistic model based on the intrinsic factors and extrinsic factors, wherein the model incorporates node characteristics into infection probability; and refining, by the system, the model through concurrently learning respective node thresholds and hidden infection network structure of the model.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 9, 2019
    Inventors: Gang Hu, Xiang Li, Hai Feng Liu, Jing Mei, Eryu Xia, En Liang Xu, Shi Wan Zhao
  • Patent number: 10279968
    Abstract: A tamper-evident closure for containers includes a closure shell having a top surface and a depending skirt. The top surface defines a first aperture therethrough and a frangible portion. The skirt defines an open lower end for engaging a container. A tamper-evident tearable member overlies the top surface of the closure shell and defines a second aperture overlying the first aperture. A removable closure cap overlies the top surface of the closure shell and the tearable member. The closure cap has an annular ring projecting downwardly from an underside of the closure cap and extending through the first and second apertures. The annular ring attaches to an underside of the frangible portion. At least partial removal of the closure cap from the top surface of the closure shell peels the frangible portion away from the top surface of the closure shell along the scoring, and tears the tamper-evident member.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: May 7, 2019
    Assignee: West Pharmaceutical Services, Inc.
    Inventors: Michael A. Carvajal, Sean J. Corrigan, Keith Grider, Phil Humphrey, Markus Vor Dem Esche, John R. Wolfe, Xia Zhao
  • Patent number: 10258744
    Abstract: A pharmaceutical syringe piston having a longitudinal axis includes a body having a central face portion with a first outer circumference and maximum first diameter. A cylindrical sealing portion proximate the central face portion has first and second axial ends and a wall extending therebetween. The wall has a second outer circumference and a second diameter essentially constant along the longitudinal axis between the first and second axial ends of the cylindrical sealing portion and is larger than the maximum first diameter. An annular curved portion has a maximum outer diameter less than the second diameter and connects the first axial end of the cylindrical sealing portion to the first outer circumference. An inert film encloses the central face portion and at least a part of the annular curved portion and has an outer boundary between the first axial end of the cylindrical sealing portion and the first outer circumference.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: April 16, 2019
    Assignee: West Pharmaceutical Services, Inc.
    Inventors: Jeffrey M. Laubach, Jurgen Brinkhues, Heike Gruen, Joel Worman, Xia Zhao, Jason Mattia
  • Publication number: 20180348834
    Abstract: A method and device for determining static equivalences of distribution networks is provided. The method comprises: acquiring node admittance matrices related to a border node and a distribution network, power loss and a voltage value and a current value of the border node; constructing static equivalence determination conditions for determining static equivalences of the distribution network, comprising a consistency of sensitivity equation, a consistency of power loss equation, an equivalent network power balance equation and a Kirchhoff's current equation; and calculating static equivalent parameters according to the static equivalence determination conditions. The inventive method and device are simple and effective, where the consistency of sensitivity and power loss before and after equivalence are considered comprehensively, and where the distributed generators' voltage and power support characteristics in an active distribution network are reserved.
    Type: Application
    Filed: October 10, 2017
    Publication date: December 6, 2018
    Inventors: Juan Yu, Bo Hu, Wei Dai, Linwei Li, Wei Yan, Xia Zhao
  • Patent number: 10126802
    Abstract: The present disclosure discloses a method and device for determining static equivalences of distribution networks, relating to the technical field of static equivalences of power systems. The method comprises: acquiring node admittance matrices related to a border node and a distribution network, power loss and a voltage value and a current value of the border node; constructing static equivalence determination conditions for determining static equivalences of the distribution network, comprising a consistency of sensitivity equation, a consistency of power loss equation, an equivalent network power balance equation and a Kirchhoff's current equation; and calculating static equivalent parameters according to the static equivalence determination conditions.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: November 13, 2018
    Inventors: Juan Yu, Bo Hu, Wei Dai, Linwei Li, Wei Yan, Xia Zhao
  • Publication number: 20180291371
    Abstract: Provided are a method for constructing a nucleic acid single-stranded cyclic library and the reagents used therein. By the combination of interruption via a transposase with a restricted nick translation reaction, the method realizes a simple and rapid nucleic acid single-stranded cyclic library construction.
    Type: Application
    Filed: November 26, 2014
    Publication date: October 11, 2018
    Applicant: BGI Shenzhen Co., Ltd.
    Inventors: Chunyu Geng, Ruoying Chen, Yuan Jiang, Xia Zhao, Rongrong Guo, Lingyu He, Yaqiao Li, Wenwei Zhang, Hui Jiang, Radoje Drmanac
  • Publication number: 20180121232
    Abstract: Methods, computer program products, and systems are presented. The methods include, for instance: synchronizing, by one or more processor, first virtual machine(s) with a second virtual machine, the synchronizing comprising mirroring first input events to the first virtual machine(s); and customizing, by the one or more processor, the first virtual machine(s), the customizing comprising suspending the synchronizing and facilitating sending of second input events to the first virtual machine(s). In one embodiment, the synchronizing comprises cloning the second virtual machine to create the first virtual machine(s), the cloning comprising initializing the first virtual machine(s), and copying second virtual machine state information to the first virtual machine(s).
    Type: Application
    Filed: December 27, 2017
    Publication date: May 3, 2018
    Inventors: Shuai TAN, De Jun WANG, Jin Qiang WU, Qiu Xia ZHAO
  • Publication number: 20180044668
    Abstract: The present invention provides a novel method for ligating an adapter to a target polynucleotide and methods of generating a library of mate-pair polynucleotide constructs that employ such a ligation method. Libraries and arrays comprising mate-pair polynucleotide constructs, and methods of sequencing libraries and arrays comprising mate-pair polynucleotide constructs, are also provided.
    Type: Application
    Filed: October 13, 2015
    Publication date: February 15, 2018
    Applicant: BGI SHENZHEN CO., LIMITED
    Inventors: Yuan JIANG, Radoje DRMANAC, Evan HUROWITZ, Andrei ALEXEEV, Xia ZHAO, Jie RUAN
  • Publication number: 20180030532
    Abstract: Provided are an adaptor element in a bubble shape, a method of constructing a sequencing library with such an adapter element. The adaptor element is a hybrid formed with a long-chain nucleic acid A and a short-chain nucleic acid B. The hybrid is in the bubble shape with paired regions at two terminals and a non-paired region in the middle.
    Type: Application
    Filed: November 21, 2014
    Publication date: February 1, 2018
    Inventors: Yuan Jiang, Xia Zhao, Qiaoling Li, Shengmao Liu, Bo Wang, Li Chen, Wenwei Zhang, Hui Jiang, Radoje Drmanac
  • Patent number: 9875130
    Abstract: Methods, computer program products, and systems are presented. The methods include, for instance: synchronizing, by one or more processor, first virtual machine(s) with a second virtual machine, the synchronizing comprising mirroring first input events to the first virtual machine(s); and customizing, by the one or more processor, the first virtual machine(s), the customizing comprising suspending the synchronizing and facilitating sending of second input events to the first virtual machine(s). In one embodiment, the synchronizing comprises cloning the second virtual machine to create the first virtual machine(s), the cloning comprising initializing the first virtual machine(s), and copying second virtual machine state information to the first virtual machine(s).
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: January 23, 2018
    Assignee: International Business Machines Corporation
    Inventors: Shuai Tan, De Jun Wang, Jin Qiang Wu, Qiu Xia Zhao
  • Publication number: 20170355981
    Abstract: A method and reagent for constructing a nucleic acid double-linker single-strand cyclic library.
    Type: Application
    Filed: November 26, 2014
    Publication date: December 14, 2017
    Applicants: BGI SHENZHEN, BGISHENZHEN CO., LIMITED
    Inventors: Yuan JIANG, Qiaoling LI, Andrei ALEXEEV, Evan HUROWITZ, Xia ZHAO, Tong WANG, Chao DONG, Dong LI, Radoje DRMANAC, Wenwei ZHANG, Hui JIANG
  • Publication number: 20170356039
    Abstract: Provided are a vesicular linker and a single-chain cyclic library constructed by using the linker. The library can be used for RNA sequencing and other sequencing platforms dependent on a single-stranded cyclic library, and has the advantages of high throughput sequencing, high accuracy and simple operations.
    Type: Application
    Filed: November 21, 2014
    Publication date: December 14, 2017
    Inventors: Yuan Jiang, Jing Guo, Xiaojun Ji, Chunyu Geng, Kai Tian, Xia Zhao, Huaiqian Xu, Wenwei Zhang, Hui Jiang, Radoje Drmanac
  • Publication number: 20170349893
    Abstract: A method and reagent for constructing a nucleic acid double-joint single-strand cyclical library.
    Type: Application
    Filed: November 26, 2014
    Publication date: December 7, 2017
    Applicants: BGI SHENZHEN, BGI SHENZHENN CO., LIMITED
    Inventors: Yuan JIANG, Xia ZHAO, Andrei ALEXEEV, Radoje DRMANAC, Wenwei ZHANG, Hui JIANG
  • Patent number: 9787219
    Abstract: A modulation policy for a modular multi-level convertor, determining a switching state of each submodule by combining the current direction of each bridge arm and the capacitor voltage order of the submodules based on a carrier stacking method. The beneficial effects of the modulation policy are that: each phase only needs a modulation wave and N carriers, given N submodules of each upper bridge arm or lower bridge arm of the modular multi-level convertor; the modular multi-level convertor can output N+1 levels without carrier phase shift; N devoted submodules of each phase are guaranteed at any time; and the submodules' capacitor voltage balancing can be controlled without a closed-loop control policy. The modulation policy facilitates adjustment of the modular multi-level convertor voltage and power class, has unlimited number of levels, has a high precision control algorithm, is easy to realize in engineering and saves software and hardware resources.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: October 10, 2017
    Assignee: CHINA UNIVERSITY OF MINING AND TECHNOLOGY
    Inventors: Xiaojie Wu, Zheng Gong, Peng Dai, Gaige Liang, Yiwen Geng, Quanjun Guo, Juan Zhou, En Fang, Xia Zhao, Huaxia Dai, Xiao Zong, Guangsheng Liu
  • Patent number: 9785544
    Abstract: The present invention discloses a manager, a test agent installed on a personal mobile device and methods thereof. The manager comprises: a first network connection module configured to establish a connection with the mobile device through Internet, the mobile device being installed with a test agent for performing test operation on a mobile application on the mobile device; and a security module configured to communicate with the test agent through the first network connection module to make the test agent perform security control on the mobile device. According to the manager, mobile devices, and methods of the present invention, the cost such as maintenance cost of the data center and purchase cost of mobile devices can be reduced dramatically. It is not necessary to analyze market demands since mobile devices owned by the users of the mobile devices are the mobile devices that need to be tested by the tester.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: October 10, 2017
    Assignee: International Business Machines Corporation
    Inventors: Shuai B J Tan, Dejun Wang, Jin Qiang Wu, Jing Wu, Qiu Xia Zhao
  • Publication number: 20170251641
    Abstract: The current invent relates to the construction and application of a three-line breeding system in the bay scallop southern subspeciesĂ—Peruvian scallop hybrids. The said three-line consists of a male sterile line, a maintainer line and a restorer line. A combination of male sterile line and maintainer line is obtained by continuously backcrossing the male sterile individuals selected from F1 inter-specific hybrid families with sperm of the selfing family of the sperm-providing Peruvian scallops until the progenies are all male sterile. The restorer line is obtained by continuously backcrossing selected individuals from the male sterile line with sperm of the selfing family of a Peruvian scallop until the progenies are all hermaphroditic and exhibit excellent production traits. Commercial male sterile brood stocks are produced by backcrossing the male sterile line with the maintainer line and commercial hybrid spats are produced by backcrossing the male sterile line and the restorer line.
    Type: Application
    Filed: September 2, 2014
    Publication date: September 7, 2017
    Inventors: Chunde Wang, Bin Ma, Kuifu Sun, Yuming Zhao, Bo Liu, Shun Zhou, Wenqi Wang, Xia Zhao, Guoying Miao
  • Publication number: 20170245477
    Abstract: The current invent relates to the construction and application of a three-line breeding system in the bay scallopĂ—Peruvian scallop hybrids. The said three-line consists of a male sterile line, a maintainer line and a restorer line. A combination of male sterile line and maintainer line is obtained by continuously backcrossing the male sterile individuals selected from F1 inter-specific hybrid families with sperm of the selfing family of the sperm-providing Peruvian scallops until the progenies are all male sterile. The restorer line is obtained by continuously backcrossing selected individuals from the male sterile line with sperm of the selfing family of a Peruvian scallop until the progenies are all hermaphroditic and exhibit excellent production traits. Commercial male sterile brood stocks are produced by backcrossing the male sterile line with the maintainer line and commercial hybrid spats are produced by backcrossing the male sterile line and the restorer line.
    Type: Application
    Filed: September 2, 2014
    Publication date: August 31, 2017
    Inventors: Chunde Wang, Bin Ma, Kuifu Sun, Yuming Zhao, Bo Liu, Shun Zhou, Wenqi Wang, Xia Zhao, Guoying Miao