Patents by Inventor Xiadong Li
Xiadong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8815525Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: February 25, 2009Date of Patent: August 26, 2014Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 8802379Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: September 2, 2010Date of Patent: August 12, 2014Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 8263341Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: April 22, 2011Date of Patent: September 11, 2012Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 8247542Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: April 15, 2011Date of Patent: August 21, 2012Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Publication number: 20110244563Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: ApplicationFiled: April 15, 2011Publication date: October 6, 2011Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 7847080Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: October 24, 2007Date of Patent: December 7, 2010Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 7834165Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: May 1, 2007Date of Patent: November 16, 2010Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 7799905Abstract: Isolated or recombinant nucleic acids encoding for a taste receptor polypeptide that is involved in human taste are provide as well as vectors and host cells containing same. This taste receptor is a GPCR polypeptide which is commonly known in the art as T1R1 and is a member of the T1R taste receptor family.Type: GrantFiled: October 15, 2008Date of Patent: September 21, 2010Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 7772385Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: October 23, 2007Date of Patent: August 10, 2010Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 7705121Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: May 1, 2007Date of Patent: April 27, 2010Assignee: Senomyx, Inc.Inventors: Jon Elliott Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Publication number: 20090233807Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: ApplicationFiled: February 25, 2009Publication date: September 17, 2009Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Publication number: 20090176657Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: ApplicationFiled: February 25, 2009Publication date: July 9, 2009Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 7524637Abstract: Functional assays that use the T1R1 receptor to screen for taste modulatory compounds are provided. These assays include cell-based assays and high throughput compound assays to identify compounds that activate T1R1 or modulate T1R1 receptor activation by compound. Preferred functional assays detect the effect of a putative taste modulatory compound on cell voltage or intracellular calcium in a cell that expresses a T1R1 polypetide, preferably in association with a G protein, e.g. G{acute over (?)}15. Compounds identified using these assays have potential application as flavor enhancer and modulators in foods and beverage for human or animal consumption.Type: GrantFiled: December 1, 2003Date of Patent: April 28, 2009Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Publication number: 20090093051Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: ApplicationFiled: October 15, 2008Publication date: April 9, 2009Inventors: JON ELLIOT ADLER, SERGEY ZOZULYA, XIADONG LI, SHAWN O'CONNELL, LENA STASZEWSKI
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Patent number: 7507544Abstract: Functional assays that use the T1R3 receptor to screen for taste modulatory compounds are provided. These assays include cell-based assays and high throughput functional assays that identify compounds which activate or modulate T1R3 receptor activation. Preferred functional assays detect the effect of a putative taste modulatory compound on intracellular voltage or intracellular calcium of a cell that expresses TIR3 polypeptide, preferably in association with a G protein, e.g. Gdl5. The compounds identified in such functional assays potentially have application as taste modulators and potential flavor enhancers or modulators for additives to foods and beverages for human or animal consumption.Type: GrantFiled: December 2, 2003Date of Patent: March 24, 2009Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Publication number: 20090004676Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically. T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: ApplicationFiled: May 15, 2007Publication date: January 1, 2009Applicant: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 7452685Abstract: Binding assays for identifying components that modulate human T1R1 polypeptide-associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R1 polypeptide or the modulation of the specific binding of another compound that specifically binds human T1R1 polypeptide. The binding assays may include the use of detectable labels, e.g., radionuclides, enxymes, fluorophores, and the like. Compounds identified in these binding assays have potential application as T1R1 taste modulators and can be used as additives in compositions for human or animal consumption.Type: GrantFiled: December 1, 2003Date of Patent: November 18, 2008Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Publication number: 20080038741Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: ApplicationFiled: May 1, 2007Publication date: February 14, 2008Applicant: Senomyx, Inc.Inventors: Jon Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Publication number: 20080026404Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: ApplicationFiled: May 1, 2007Publication date: January 31, 2008Applicant: Senomyx, Inc.Inventors: Jon Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski
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Patent number: 7244835Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: March 7, 2001Date of Patent: July 17, 2007Assignee: Senomyx, Inc.Inventors: Jon Elliot Adler, Sergey Zozulya, Xiadong Li, Shawn O'Connell, Lena Staszewski