Patents by Inventor Xiajuan Huan

Xiajuan Huan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-[4-(meihylaminomethyl)phenyl]-5-fluoro- benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof
    Patent number: 11174237
    Abstract: Disclosed are a 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, a preparation method therefor and an application thereof. Specifically, disclosed are three crystalline forms, i.e., crystalline forms A, B, and C, of 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride (formula I), preparation methods for the three crystalline forms, and use of the three crystalline forms in preparation of drugs.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: November 16, 2021
    Assignees: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD.
    Inventors: Chunhao Yang, Zehong Miao, Cun Tan, Xiajuan Huan, Jian Ding, Yi Chen
  • 2-[4-(METHYLAMINOMETHYL)PHENYL]-5-FLUORO-BENZOFURAN-7-CARBOXAMIDE HYDROCHLORIDE POLYMORPH, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Publication number: 20200172502
    Abstract: Disclosed are a 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, a preparation method therefor and an application thereof. Specifically, disclosed are three crystalline forms, i.e., crystalline forms A, B, and C, of 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride (formula I), preparation methods for the three crystalline forms, and use of the three crystalline forms in preparation of drugs.
    Type: Application
    Filed: May 31, 2018
    Publication date: June 4, 2020
    Inventors: Chunhao YANG, Zehong MIAO, Cun TAN, Xiajuan HUAN, Jian DING, Yi CHEN
  • Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof
    Patent number: 10597399
    Abstract: A class of substituted triazolopiperazine compounds represented by formula (I), tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods therefor, intermediates and a use thereof in the preparation of drugs for prevention and treatment of diseases associated with PARP including various ischemic diseases, neurodegenerative diseases and cancers.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: March 24, 2020
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Ao Zhang, Zehong Miao, Pingyuan Wang, Shanshan Song, Zilan Song, Xiajuan Huan, Zhoulong Fan, Jian Ding
  • Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof
    Publication number: 20180265516
    Abstract: The present invention relates to a class of substituted triazolopiperazine compounds, tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods therefor, intermediates and a use thereof in the preparation of drugs for prevention and treatment of diseases associated with PARP including various ischemic diseases, neurodegenerative diseases and cancers.
    Type: Application
    Filed: May 23, 2018
    Publication date: September 20, 2018
    Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Ao Zhang, Zehong Miao, Pingyuan Wang, Shanshan Song, Zilan Song, Xiajuan Huan, Zhoulong Fan, Jian Ding
  • Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors
    Patent number: 9255106
    Abstract: Provided is a piperazinotriazole compound represented by general formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer or hydrate thereof. Also provided are a pharmaceutical composition comprising the compound, a method for preparing the compound and a method of use thereof as a high-selectivity poly(adenosine diphosphate-ribose)polymerase-1 (PARP-1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: February 9, 2016
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Ao Zhang, Zehong Miao, Na Ye, Xiajuan Huan, Zilan Song, Chuanhuizi Chen, Yi Chen, Jian Ding
  • PIPERAZINOTRIAZOLE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN DRUG PREPARATION
    Publication number: 20150166544
    Abstract: Provided is a piperazinotriazole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose)polymerase-1 (PARP 1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.
    Type: Application
    Filed: July 24, 2013
    Publication date: June 18, 2015
    Inventors: Ao Zhang, Zehong Miao, Na Ye, Xiajuan Huan, Zilan Song, Chuanhuizi Chen, Yi Chen, Jian Ding