Abstract: A system and method for executing input/output (I/O) tasks for clients in a distributed computing system. One or more I/O requests made by a client are received. The operation instructions for the request data in the I/O requests are separated from the request data. A data representation called data label (or label) is created for executing operation instructions of the I/O requests. A data label corresponds to each of the I/O request and includes a unique identifier, information to the source and/or destination for the request data, and an operation instruction separated from the request data. The data label is pushed into a distributed label queue and is dispatched to an individual worker node according to a scheduling policy. The worker node executes the I/O tasks by executing the dispatched data label. The system and method can execute I/O tasks independently and decoupled from the client applications.

Abstract: Provided herein are single-domain antibodies targeting BCMA, and chimeric antigen receptors (such as monovalent CAR, and multivalent CAR including bi-epitope CAR) having one or more anti-BCMA single-domain antibodies. Further provided are engineered immune effector cells (such as T cells) having the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: The present application provides single-domain antibodies targeting BCMA, and chimeric antigen receptors (such as monovalent CAR, and multivalent CAR including bi-epitope CAR) comprising one or more anti-BCMA single-domain antibodies. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: A system and method for executing input/output (I/O) tasks for clients in a distributed computing system. One or more I/O requests made by a client are received. The operation instructions for the request data in the I/O requests are separated from the request data. A data representation called data label (or label) is created for executing operation instructions of the I/O requests. A data label corresponds to each of the I/O request and includes a unique identifier, information to the source and/or destination for the request data, and an operation instruction separated from the request data. The data label is pushed into a distributed label queue and is dispatched to an individual worker node according to a scheduling policy. The worker node executes the I/O tasks by executing the dispatched data label. The system and method can execute I/O tasks independently and decoupled from the client applications.

Abstract: The present application provides single-domain antibodies targeting BCMA, and chimeric antigen receptors (such as monovalent CAR, and multivalent CAR including bi-epitope CAR) comprising one or more anti-BCMA single-domain antibodies. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: Provided herein are single-domain antibodies targeting BCMA, and chimeric antigen receptors (such as monovalent CAR, and multivalent CAR including bi-epitope CAR) having one or more anti-BCMA single-domain antibodies. Further provided are engineered immune effector cells (such as T cells) having the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: Present invention relates to a human lung tissues-active targeting immune nanoliposome of methylprednisolone, wherein, nanoliposomes loaded with therapy drugs is covalently coupled with nanobodies against human pulmonary surfactant protein A. Wherein, the therapy drug is methylprednisolone sodium succinate, the nanoliposome consists of phospholipids, cholesterols and long cycling materials. The molar ratio of the methylprednisolone sodium succinate to phospholipids within the nanoliposome is 0.30-0.45. Present invention successfully provides a new human lung tissues targeting hormone preparation, wherein, the nanoliposome serves as a carrier, the nanobody against human pulmonary surfactant protein A serves as a specific lung tissue targeting ligand, methylprednisolone sodium succinate serves as a therapy drug. In accordance with present invention, an efficient, stable human lung tissues-active targeting immune nanoliposome, with specific active lung targeting, is prepared.

Abstract: The present invention provides a cell-based platform for controllable, regionalized, and cost-effective delivery of immunomodulator and other therapeutic proteins, which is widely applicable in cancer immunotherapy.

Abstract: The present invention relates to the field of biochemistry and pharmaceutical technologies. The present invention provides nanobodies that bind to human pulmonary surfactant protein A (SP-A) as well as the preparing methods and use of the same. The nanobody comprise an amino acid sequence having the formula of Q(x)2LVESGG(x)2V(x)2G(x)SL(x)LS(x)24E(x)n2 KG(x)4S(x)n3T(x)2Y(x)C(x)n4S(x)n5V(x)n6R; wherein x is amino acid; n2˜n6 are positive integers; 1?n2?21; 1?n3?19; 1?n4?50; 1?n5?22; 1?n6?8. The present invention take fresh frozen sections of lung as antigen, gene sequences with high affinity with hSP-A were obtained by constructing an SP-A antibody library and affinity selection, and nanobodies with high affinity and small molecular weight were obtained by induced expression of the gene sequences through a prokaryotic expression vector. Immunohistochemistry and in vivo imaging in nude mice showed the nanobodies have high specificity for targeting lung tissue.

Abstract: In one embodiment, the present disclosure describes a method of optimizing memory access in a hierarchical memory system. The method includes determining a request rate from an ith layer of the hierarchical memory system for each of n layers in the hierarchical memory system. The method also includes determining a supply rate from an (i+1)th layer of the hierarchical memory system for each of the n layers in the hierarchical memory system. The supply rate from the (i+1)th layer of the hierarchical memory system corresponds to the request rate from the ith layer of the hierarchical memory system. The method further includes adjusting a set of computer architecture parameters of the hierarchical memory system or a schedule associated with an instruction set to utilize heterogeneous computing resources within the hierarchical memory system to match a performance of each adjacent layer of the hierarchical memory system.

Abstract: Present invention relates to a human lung tissues-active targeting immune nanoliposome of methylprednisolone, wherein, nanoliposomes loaded with therapy drugs is covalently coupled with nanobodies against human pulmonary surfactant protein A. Wherein, the therapy drug is methylprednisolone sodium succinate, the nanoliposome consists of phospholipids, cholesterols and long cycling materials. The molar ratio of the methylprednisolone sodium succinate to phospholipids within the nanoliposome is 0.30-0.45. Present invention successfully provides a new human lung tissues targeting hormone preparation, wherein, the nanoliposome serves as a carrier, the nanobody against human pulmonary surfactant protein A serves as a specific lung tissue targeting ligand, methylprednisolone sodium succinate serves as a therapy drug. In accordance with present invention, an efficient, stable human lung tissues-active targeting immune nanoliposome, with specific active lung targeting, is prepared.

Abstract: A pressure casting machine can be configured to mold a molten material into a workpiece. The pressure casting machine can include a vacuum chamber and a pressure casting mechanism coupled to the vacuum chamber. The vacuum chamber can include a processing section having a top wall and a bottom wall opposite to the top wall, a first gate configured to seal the processing section, and a first vacuum pump coupled to the processing section. The pressure casting mechanism can include a first driver positioned adjacent to the top wall, a first core received in the processing section and coupled to the first driver, a second core received in the processing section, and a plurality of pushing members received in the processing section. The second core can be coupled to the bottom wall and opposite to the first core. The pushing members can be coupled to the top wall.

Abstract: The present invention relates to the field of biochemistry and pharmaceutical technologies. The present invention provides nanobodies that bind to human pulmonary surfactant protein A (SP-A) as well as the preparing methods and use of the same. The nanobody comprise an amino acid sequence having the formula of Q(x)2LVESGG(x)2V (x)2G(x) SL(x) LS(x)24E (x)n2KG(x)4S(x)n3T(x)2Y(x) C(x)n4S(x)n5V(x)n6R; wherein x is any amino acid; n2˜n6 are positive integers; 1?n2?21; 1?n3?19; 1?n4?50; 1?n5?22; 1?n6?8. The present invention take fresh frozen sections of lung as antigen, gene sequences with high affinity with hSP-A were obtained by constructing an SP-A antibody library and affinity selection, and nanobodies with high affinity and small molecule weight were obtained by induced expression of the gene sequences through a prokaryotic expression vector. Immunohistochemistry and in vivo imaging in nude mice showed the nanobodies have high specificity for targeting lung tissue.

Abstract: A vacuum container includes a connecting chamber a valve chamber, a discharging chamber, and a sealing member. The connecting chamber defines an inclined sealing surface. The discharging chamber defines a discharging passage therein. The valve chamber interconnects the connecting chamber and the discharging chamber. The sealing member is slidably received in the valve chamber, wherein the sealing member is configured for sliding toward the sealing surface, such that the sealing member resists the inclined sealing surface to hermetically isolate the connecting chamber from the discharging chamber.

Abstract: A pressure casting machine can be configured to mold a molten material into a workpiece. The pressure casting machine can include a vacuum chamber and a pressure casting mechanism coupled to the vacuum chamber. The vacuum chamber can include a processing section having a top wall and a bottom wall opposite to the top wall, a first gate configured to seal the processing section, and a first vacuum pump coupled to the processing section. The pressure casting mechanism can include a first driver positioned adjacent to the top wall, a first core received in the processing section and coupled to the first driver, a second core received in the processing section, and a plurality of pushing members received in the processing section. The second core can be coupled to the bottom wall and opposite to the first core. The pushing members can be coupled to the top wall.

Abstract: A vacuum container includes a connecting chamber a valve chamber, a discharging chamber, and a sealing member. The connecting chamber defines an inclined sealing surface. The discharging chamber defines a discharging passage therein. The valve chamber interconnects the connecting chamber and the discharging chamber. The sealing member is slidably received in the valve chamber, wherein the sealing member is configured for sliding toward the sealing surface, such that the sealing member resists the inclined sealing surface to hermetically isolate the connecting chamber from the discharging chamber.

Abstract: A method and apparatus for prefetching data from memory for a multicore data processor. A prefetcher issues a plurality of requests to prefetch data from a memory device to a memory cache. Consecutive cache misses are recorded in response to at least two of the plurality of requests. A time between the cache misses is determined and a timing of a further request to prefetch data from the memory device to the memory cache is altered as a function of the determined time between the two cache misses.

Abstract: A system, method, and set of protocols for dynamic group communication are provided for enabling dynamic process migration and dynamic group membership management. A process in a group receives and distributes a migration signal. Group communication continues while the processes in the group asynchronously reach a global superstep and then a synchronization point. The processes then spawn a new process on a new device and update group membership information. The new process operates in continuous execution with the new group.

Abstract: A method and apparatus for prefetching data from memory for a multicore data processor. A prefetcher issues a plurality of requests to prefetch data from a memory device to a memory cache. Consecutive cache misses are recorded in response to at least two of the plurality of requests. A time between the cache misses is determined and a timing of a further request to prefetch data from the memory device to the memory cache is altered as a function of the determined time between the two cache misses.

Abstract: A memory server provides data access as a service to clients and has a memory service architecture and components for removing data management burdens from the client processor and providing increased speed and utility for the client through aggressive prediction of client memory requirements and fast provision of data.