Abstract: The present invention relates to a strategy for combining a berberine analog with a JAK inhibitor in the treatment of inflammatory diseases of the gastrointestinal tract. Specifically, provided by the present invention is a pharmaceutical composition containing the berberine analog and the JAK inhibitor, and a use thereof in the treatment of inflammatory diseases of the gastrointestinal tract. The composition may exhibit an improved effect over the use of berberine or the JAK inhibitor alone.

Abstract: The present invention relates to a composition comprising 4-hexylresorcinol(4-HR) as an active ingredient for prevention or treatment of a bone disease, and a formulation thereof. The composition comprising 4-hexylresorcinol (4-HR) as an active ingredient, or an ointment thereof was found to improve bone thickness, density, and strength and control bone remodeling by promoting the differentiation of osteoblasts and suppressing the proliferation and differentiation of osteoclasts in osteoporosis-induced animal models. Thus, the composition or ointment comprising 4-hexylresorcinol (4-HR) as an active ingredient can be provided as a therapeutic agent for bone diseases including bone fracture, osteoarthritis, rheumatoid arthritis, and osteoporosis.

Abstract: Provided is a method for coating an implant using heat, and more particularly to a method for coating only the surface of an implant with a biocompatible polymer by using heat while maintaining physical characteristics of the implant. The method for coating an implant using heat according to the present invention may effectively introduce a biocompatible polymer onto a three-dimensional material surface and thus may overcome the spatial limitations of light, and enables mass-coating and thus may be effectively used in the manufacture of an implant coated with a biocompatible polymer.

Abstract: A class of five-membered fused with six-membered heterocyclic compounds represented by formula I and a pharmaceutical composition, preparation, and an application thereof are disclosed. These compounds have TRK kinase inhibitory activity and can treat diseases related to TRK dysfunction.

Abstract: Provided are a preparation and applications of a six-membered fused with six-membered heterocyclic compound, specifically, provided in the present invention is a compound as represented by formula I as follows, where the definitions of the groups are as described in the description. The compound has TRK kinase inhibiting activity and can serve as a pharmaceutical composition for treating TRK dysfunction-related diseases.

Abstract: A toilet tank valve structure comprises partial discharge trigger, a whole discharge trigger, and a limiting unit capable of limiting a trigger movement of the partial discharge trigger, such that the whole discharge trigger is able to move the water seal further in distance than the partial discharge trigger. The partial discharge trigger is co-axially rotatable with the whole discharge trigger. The partial discharge trigger and the whole discharge trigger couple with a water seal.

Abstract: A toilet tank valve structure comprises a knob unit, a rotatable shaft unit, a pole unit, a whole discharge pull wire, a partial discharge pull wire, a whole discharge assembly, a partial discharge assembly, and a water seal; the knob unit comprising a partial discharge knob and a whole discharge knob; the rotatable shaft unit comprising a shaft core and a shaft sleeve; the pole unit comprising a partial discharge pole and a whole discharge pole; the whole discharge knob being secured to an outer end of the shaft sleeve, an inner end of the shaft sleeve being secured to a first end of the whole discharge pole, a second end of the whole discharge pole being connected to the whole discharge pull wire to link the whole discharge assembly and the water seal; the partial discharge knob being secured to an outer end of the shaft core, the shaft core being inserted into the shaft sleeve, an inner end of the shaft core being secured to a first end of the partial discharge pole, a second end of the partial discharge p

Abstract: A method and system for displaying information from a digital document in a format that presents a paper page-like appearance, including a full-page display and a side-by-side display. This invention provides a method for converting source documents, such as are common on Web sites on the Internet, into a side-by-side printed page format that maintains hyperlinks, images, sound files, video files, and text, while permitting the user to read the information in the familiar book or magazine style.