Patents by Inventor Xian Jun Loh

Xian Jun Loh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11583612
    Abstract: There is provided a material comprising a multi-block thermogelling polymer, said multi-block thermogelling polymer comprising a hydrophilic polymer block; a thermosensitive polymer block; and a hydrophobic polymer block, wherein the hydrophilic polymer block, the thermosensitive polymer block and the hydrophobic polymer block are chemically coupled together by at least one of urethane/carbamate, carbonate, ester linkages or combinations thereof, and wherein the material is suitable for use as a vitreous substitute. Also provided are a method of preparing said material and a synthetic vitreous humour or part thereof comprising said material.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: February 21, 2023
    Assignees: Agency for Science, Technology and Research, National University Hospital (Singapore) Pte Ltd, National University of Singapore, Singapore Health Services Pte Ltd
    Inventors: Xian Jun Loh, Xinyi Su, Zengping Liu, Gopal Lingam, Veluchamy Amutha Barathi, Walter Hunziker
  • Patent number: 11491227
    Abstract: The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: November 8, 2022
    Assignee: CAMBRIDGE ENTERPRISE LIMITED
    Inventors: Oren Scherman, Eric Appel, Xian Jun Loh, Frank Biedermann, Matthew Rowland
  • Publication number: 20210203023
    Abstract: This invention relates to an electrochemical cell comprising an anode structure comprising an element selected from the group consisting of group 1, group 2, group 8, group 12 and group 13 of the Periodic Table of Elements; a cathode structure comprising a catalyst; and a hydrogel located between the anode structure and the cathode structure. In a preferred embodiment, the cell comprises the anode of Zinc, the catalyst of CoOx/C, the hydrogel of free-standing alkaline polyacrylamide hydrogel, wherein said hydrogel was first synthesized via UV-initiated radical polymerization of acrylamides, followed by exchange of water with an alkaline electrolyte of potassium hydroxide (KOH). The invention further relates to a method of manufacturing such an electrochemical cell and the use of a hydrogel in a metal/air battery.
    Type: Application
    Filed: March 29, 2017
    Publication date: July 1, 2021
    Inventors: Mein Jin TAN, Bing LI, Xian Jun LOH, Yun ZONG, Zhao LIU, Xiao Ming GE
  • Publication number: 20200276357
    Abstract: There is provided a material comprising a multi-block thermogelling polymer, said multi-block thermogelling polymer comprising a hydrophilic polymer block; a thermosensitive polymer block; and a hydrophobic polymer block, wherein the hydrophilic polymer block, the thermosensitive polymer block and the hydrophobic polymer block are chemically coupled together by at least one of urethane/carbamate, carbonate, ester linkages or combinations thereof, and wherein the material is suitable for use as a vitreous substitute. Also provided are a method of preparing said material and a synthetic vitreous humour or part thereof comprising said material.
    Type: Application
    Filed: February 28, 2020
    Publication date: September 3, 2020
    Inventors: Xian Jun LOH, Xinyi SU, Zengping LIU, Gopal LINGAM, Amutha Veluchamy BARATHI, Walter HUNZIKER
  • Publication number: 20200263025
    Abstract: The present invention relates to a core-shell nanoparticle comprising (a) an inorganic core comprising a nanoparticle comprising a metal, a metal oxide or combination thereof, and a silica component; (b) a shell material comprising a copolymer having at least two polymers selected from a pH-responsive polymer and a hydrophobic polymer; and (c) a crosslinker that conjugates the shell material to the inorganic core. There is also provided a method for producing the core-shell nanoparticle and uses thereof.
    Type: Application
    Filed: October 12, 2018
    Publication date: August 20, 2020
    Inventors: Zibiao Li, Beng Hoon Maureen Janet Tan, Xian Jun Loh, Jing Yang
  • Patent number: 10683382
    Abstract: A copolymer comprising an oxygenated polyaromatic alcohol and a poly (alkylene oxide) alkyl ether (meth)acrylate is disclosed, wherein the oxygenated polyaromatic alcohol is preferably lignin or lignin derivative. A hydrogel comprising the copolymer and a cyclic oligosaccharide such as ?-cyclodextrin is also disclosed, which can be used in biomedical or personal care industries, for example as a carrier for an active agent.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: June 16, 2020
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Dan Kai, Xian Jun Loh
  • Publication number: 20200055994
    Abstract: Provided herein is a polymer having formula I: where m, n, and R1 are as defined herein, and the polymer has a number average molecular weight of the polymer of from 500 to 80,000 Daltons. Also provided herein are block copolymers of the polymer of formula I, as well as processes to make the polymer and block copolymers thereof.
    Type: Application
    Filed: September 6, 2019
    Publication date: February 20, 2020
    Inventors: Xian Jun LOH, Sing Shy LIOW
  • Publication number: 20200016064
    Abstract: In the present invention, a method of producing a colourant-incorporated silk fibroin is provided. In a preferred embodiment, the method comprises the steps of: i) decrystallizing a degummed silk fibroin in the presence of an acidic solution or a metal salt solution (i.e. lithium bromide); ii) mixing one or more colourants with the decrystallized silk fibroin and iii) recrystallizing the decrystallized silk fibroin containing the colourants such that it forms a recrystallized region encapsulating the colourants, thereby obtaining the colourant-incorporated silk fibroin. In addition, a cosmetic product comprising the colourant-incorporated silk fibroin is provided.
    Type: Application
    Filed: December 20, 2017
    Publication date: January 16, 2020
    Inventors: Yin Win Khin, Choon Peng Teng, Michelle Dela Cruz Regulacio, Si Yin Tee, Leng Duei Koh, Michelle Low, Xian Jun Loh, Ming Yong Han
  • Patent number: 10465147
    Abstract: Described herein are copolymers comprising at least one first water-soluble monomeric unit, at least one second water-soluble monomeric unit, and at least one monomeric unit containing a basic residue.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: November 5, 2019
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Jun Li, Zhongxing Zhang, Xian Jun Loh, Xiping Ni
  • Patent number: 10450421
    Abstract: Provided herein is a polymer having formula I: where m, n, and R1 are as defined herein, and the polymer has a number average molecular weight of the polymer of from 500 to 80,000 Daltons. Also provided herein are block copolymers of the polymer of formula I, as well as processes to make the polymer and block copolymers thereof.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: October 22, 2019
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Xian Jun Loh, Sing Shy Liow
  • Publication number: 20180044481
    Abstract: Provided herein is a polymer having formula I: where m, n, and R1 are as defined herein, and the polymer has a number average molecular weight of the polymer of from 500 to 80,000 Daltons. Also provided herein are block copolymers of the polymer of formula I, as well as processes to make the polymer and block copolymers thereof.
    Type: Application
    Filed: February 16, 2016
    Publication date: February 15, 2018
    Inventors: Xian Jun LOH, Sing Shy LIOW
  • Publication number: 20180030192
    Abstract: A copolymer comprising an oxygenated polyaromatic alcohol and a poly (alkylene oxide) alkyl ether (meth)acrylate is disclosed, wherein the oxygenated polyaromatic alcohol is preferably lignin or lignin derivative. A hydrogel comprising the copolymer and a cyclic oligosaccharide such as ?-cyclodextrin is also disclosed, which can be used in biomedical or personal care industries, for example as a carrier for an active agent.
    Type: Application
    Filed: February 18, 2016
    Publication date: February 1, 2018
    Inventors: Dan KAI, Xian Jun LOH
  • Patent number: 9822222
    Abstract: This invention relates to shape memory block copolymers comprising: at least one switching segment having a Ttrans from 10 to 70° C.; and at least one soft segment, wherein at least one of the switching segments in linked to at least one of the soft segments by at least one linkage, and wherein the copolymer transforms from a first shape to a second shape by application of a first stimulus and the copolymer transforms back to the first shape from the second shape by application of a second stimulus. The shape memory block copolymers may be biocompatible and biodegradable.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: November 21, 2017
    Assignee: Agency for Science, Technology and Research
    Inventors: Xian Jun Loh, Jun Li
  • Publication number: 20170128381
    Abstract: There is provided a core-shell particle having pores extending through its shell and a plurality of polymers that are bonded to the outer surface of the shell, wherein the polymers are comprised of repeating monomer units of formula (1): [Formula should be inserted here] wherein the substituents are as defined herein. There is also provided a method of synthesizing the core-shell particle and use of the core-shell particle as a delivery agent.
    Type: Application
    Filed: June 22, 2015
    Publication date: May 11, 2017
    Inventors: Jatin Nitin KUMAR, Connie Kin Man LIU, Ye LIU, Xian Jun LOH
  • Publication number: 20150368406
    Abstract: This invention relates to shape memory block copolymers comprising: at least one switching segment having a Ttrans from 10 to 70° C.; and at least one soft segment, wherein at least one of the switching segments in linked to at least one of the soft segments by at least one linkage, and wherein the copolymer transforms from a first shape to a second shape by application of a first stimulus and the copolymer transforms back to the first shape from the second shape by application of a second stimulus. The shape memory block copolymers may be biocompatible and biodegradable.
    Type: Application
    Filed: June 23, 2015
    Publication date: December 24, 2015
    Applicant: Agency for Science, Technology and Research
    Inventors: Xian Jun Loh, Jun Li
  • Patent number: 9089628
    Abstract: This invention relates to shape memory block copolymers comprising: at least one switching segment having a Ttrans from 10 to 70° C.; and at least one soft segment, wherein at least one of the switching segments is linked to at least one of the soft segments by at least one linkage, and wherein the copolymer transforms from a first shape to a second shape by application of a first stimulus and the copolymer transforms back to the first shape from the second shape by application of a second stimulus. The shape memory block copolymers may be biocompatible and biodegradable.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: July 28, 2015
    Assignee: Agency for Science, Technology and Research
    Inventors: Xian Jun Loh, Jun Li
  • Publication number: 20150110772
    Abstract: The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.
    Type: Application
    Filed: February 20, 2013
    Publication date: April 23, 2015
    Inventors: Oren Scherman, Eric Appel, Xian Jun Loh, Frank Biedermann, Matthew Rowland
  • Publication number: 20130095054
    Abstract: Described herein are copolymers comprising at least one first water-soluble monomeric unit, at least one second water-soluble monomeric unit, and at least one monomeric unit containing a basic residue.
    Type: Application
    Filed: October 17, 2012
    Publication date: April 18, 2013
    Inventors: Jun LI, Zhongxing ZHANG, Xian Jun LOH, Xiping NI
  • Publication number: 20130018111
    Abstract: This invention relates to shape memory block copolymers comprising: at least one switching segment having a Ttrans from 10 to 70° C.; and at least one soft segment, wherein at least one of the switching segments is linked to at least one of the soft segments by at least one linkage, and wherein the copolymer transforms from a first shape to a second shape by application of a first stimulus and the copolymer transforms back to the first shape from the second shape by application of a second stimulus. The shape memory block copolymers may be biocompatible and biodegradable.
    Type: Application
    Filed: March 18, 2011
    Publication date: January 17, 2013
    Applicant: Agency for Science ,Technology and Research
    Inventors: Xian Jun Loh, Jun Li
  • Patent number: 8350087
    Abstract: There is provided a polymer comprising blocks of at least one polyethylene glycol) block, at least one poly(propylene glycol) block and at least one poly(hydroxybutyrate) block. Also provided is a method of making the polymer and a method of using the polymer.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: January 8, 2013
    Assignees: Agency for Science, Technology and Research, National University of Singapore
    Inventors: Jun Li, Xian Jun Loh, Suat Hong Goh