Patents by Inventor Xian Shi

Xian Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tao Kinase Modulators And Method Of Use
    Publication number: 20070208166
    Abstract: The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
    Type: Application
    Filed: October 22, 2004
    Publication date: September 6, 2007
    Applicant: Exelixis, Inc.
    Inventors: Deborah Baly, Adam Galan, Mohamed Ibrahim, Christopher Jaeger, Patrick Kearney, James Leahy, Gary Lewis, Kirk McMillan, Robin Noguchi, John Nuss, Jason Parks, Kevin Schnepp, Xian Shi, Matthew Williams, Wei Xu, Wentao Zhang
  • Tie-2 modulators and methods of use
    Publication number: 20070161651
    Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
    Type: Application
    Filed: April 8, 2004
    Publication date: July 12, 2007
    Applicant: EXELIXIS, INC.
    Inventors: Mohamed Ibrahim, James Leahy, Joan Sangalang, Kevin Schnepp, Xian Shi, John Nuss
  • Protein kinase modulators and methods of use
    Publication number: 20060211709
    Abstract: Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.
    Type: Application
    Filed: May 2, 2003
    Publication date: September 21, 2006
    Inventors: Chris Buhr, Tae-Gon Baik, Sunghoon Ma, Zerom Tesfai, Longcheng Wang, Erick Co, Sergey Epshteyn, Abigail Kennedy, Baili Chen, Larisa Dubenko, Neel Anand, Tsze Tsang, John Nuss, Csabaj Peto, Kenneth Rice, Mohamed Ibrahim, Xian Shi, James Leahy, Jeff Chen, Lisa Dalrymple, Timothy Forsyth, Tai Huynh, Grace Mann, Larry Mann, Craig Takeuchi