Abstract: An example method of operation includes identifying a loudspeaker array profile defining characteristics of a loudspeaker array stored in memory, identifying a three-dimensional venue geometry value stored in the memory, defining virtual receivers to simulate acoustic characteristics within the venue geometry, defining a number of passive acoustic filter permutations to perform within a range of passive acoustic filter settings, and each passive acoustic filter setting is unique and has one or more passive acoustic filters to apply to one or more loudspeakers in the loudspeaker array, selecting performance criteria to apply to the loudspeaker array to represent its sound coverage uniformity at a given location throughout the venue geometry, calculating the performance criteria of the loudspeaker array via a passive acoustic filter setting selected from one or more of the passive acoustic filter permutations by performing a simulation with the passive acoustic filter settings, identifying an optimized passive

Abstract: An example method of operation includes performing a plurality of polar pattern permutations based on a function of an inputted magnitude and phase adjustment range, determining a plurality of polar pattern outputs, creating a list of the polar pattern outputs, and creating a set of FIR filters to apply to a loudspeaker based on a selected one of the list of polar patterns.

Abstract: An example method of operation includes identifying a loudspeaker array profile defining characteristics of a loudspeaker array stored in memory, identifying a three-dimensional venue geometry value stored in the memory, defining virtual receivers to simulate acoustic characteristics within the venue geometry, defining a number of passive acoustic filter permutations to perform within a range of passive acoustic filter settings, and each passive acoustic filter setting is unique and has one or more passive acoustic filters to apply to one or more loudspeakers in the loudspeaker array, selecting performance criteria to apply to the loudspeaker array to represent its sound coverage uniformity at a given location throughout the venue geometry, calculating the performance criteria of the loudspeaker array via a passive acoustic filter setting selected from one or more of the passive acoustic filter permutations by performing a simulation with the passive acoustic filter settings, identifying an optimized passive

Abstract: An example method of operation includes performing a plurality of polar pattern permutations based on a function of an inputted magnitude and phase adjustment range, determining a plurality of polar pattern outputs, creating a list of the polar pattern outputs, and creating a set of FIR filters to apply to a loudspeaker based on a selected one of the list of polar patterns.

Abstract: An example method of operation includes performing a plurality of polar pattern permutations based on a function of an inputted magnitude and phase adjustment range, determining a plurality of polar pattern outputs, creating a list of the polar pattern outputs, and creating a set of FIR filters to apply to a loudspeaker based on a selected one of the list of polar patterns.

Abstract: An example method of operation includes identifying a loudspeaker array profile defining characteristics of a loudspeaker array stored in memory, identifying a three-dimensional venue geometry value stored in the memory, defining virtual receivers to simulate acoustic characteristics within the venue geometry, defining a number of passive acoustic filter permutations to perform within a range of passive acoustic filter settings, and each passive acoustic filter setting is unique and has one or more passive acoustic filters to apply to one or more loudspeakers in the loudspeaker array, selecting performance criteria to apply to the loudspeaker array to represent its sound coverage uniformity at a given location throughout the venue geometry, calculating the performance criteria of the loudspeaker array via a passive acoustic filter setting selected from one or more of the passive acoustic filter permutations by performing a simulation with the passive acoustic filter settings, identifying an optimized passive

Abstract: An example method of operation includes identifying a loudspeaker array profile defining characteristics of a loudspeaker array stored in memory, identifying a three-dimensional venue geometry value stored in the memory, defining virtual receivers to simulate acoustic characteristics within the venue geometry, defining a number of passive acoustic filter permutations to perform within a range of passive acoustic filter settings, and each passive acoustic filter setting is unique and has one or more passive acoustic filters to apply to one or more loudspeakers in the loudspeaker array, selecting performance criteria to apply to the loudspeaker array to represent its sound coverage uniformity at a given location throughout the venue geometry, calculating the performance criteria of the loudspeaker array via a passive acoustic filter setting selected from one or more of the passive acoustic filter permutations by performing a simulation with the passive acoustic filter settings, identifying an optimized passive

Abstract: An example method of operation includes performing a plurality of polar pattern permutations based on a function of an inputted magnitude and phase adjustment range, determining a plurality of polar pattern outputs, creating a list of the polar pattern outputs, and creating a set of FIR filters to apply to a loudspeaker based on a selected one of the list of polar patterns.

Abstract: The present disclosure involves, systems, software, and computer-implemented methods for determining a location for a curbside branch. One example system comprises a memory storing instructions; at least one hardware processor interoperably coupled with the memory, wherein the instructions instruct the at least one hardware processor to: obtain historical and current exchange data of users associated with a particular location; obtain external data about the particular location; enrich the historical and current exchange data with the external data; identify one or more analysis rules to apply to the enriched data to determine an estimated demand for services associated with deployment of a mobile site at the particular location; compare estimated demand to a predetermined threshold; and in response to a determination that the estimated demand exceeds the predetermined threshold, identify the particular location for mobile site deployment.

Abstract: A notebook may generally comprise a plurality of sheets of paper, a binding mechanism binding the plurality of sheets together, and a cover bound to the plurality of sheets of paper disposed therebetween, the cover comprising first and second opposed covers, the first cover including a first portion and a second portion and having a hinge line extending therebetween, wherein the second portion is pivotable about the hinge line between a closed position and an open position. A notebook cover is also described.

Abstract: A notebook may generally comprise a plurality of sheets of paper, a binding mechanism binding the plurality of sheets together, and a cover bound to the plurality of sheets of paper disposed therebetween, the cover comprising first and second opposed covers, the first cover including a first portion and a second portion and having a hinge line extending therebetween, wherein the second portion is pivotable about the hinge line between a closed position and an open position. A notebook cover is also described.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of fibroblast growth factor receptor 4 (FGFR4) mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a metabolic disease, or a symptom thereof.

Abstract: A liquid crystal lens is disclosed, comprising a plurality of lens units, wherein each lens unit comprises a first substrate, a second substrate opposite to the first substrate, a liquid crystal layer disposed between the first substrate and the second substrate, an insulating layer disposed on the first substrate, and a first electrode and a first floating electrode disposed at opposite sides of the insulating layer, wherein the first electrode comprises a first portion neighboring a first side of the lens unit and a second portion neighboring a second side of the lens unit, and the first floating electrode comprises a first portion and a second portion, wherein the first portion of the first floating electrode is partially overlapped with the first portion of the first electrode, and the second portion of the first floating electrode is partially overlapped with the second portion of the first electrode.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of fibroblast growth factor receptor 4 (FGFR4) mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a metabolic disease, or a symptom thereof.

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 4 (FGFR4). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding fibroblast growth factor receptor 4. Methods of using these compounds for modulation of fibroblast growth factor receptor 4 expression and for treatment of diseases associated with expression of fibroblast growth factor receptor 4 are provided.

Abstract: Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.

Abstract: Disclosed herein are compounds, compositions and methods for modulating the expression of LMW-PTPase in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Also provided are methods for the prevention, amelioration and/or treatment of diabetes, insulin resistance, insulin deficiency, hypercholesterolemia, hyperglycemia, dyslipidemia, hyperlipidemia, hypertriglyceridemia, and hyperfattyacidemia. In some embodiments, the diabetes is type II diabetes by administration of antisense compounds targeted to LMW-PTPase.

Abstract: A syringe includes a hollow barrel, a hollow plunger movable within the barrel and a needle assembly secured within and at a distal end of the barrel. The needle assembly includes a needle holder, a resilient member that biases the needle holder toward the proximal end opening of the barrel, and a retaining member releasably secured to the needle holder via a reduced material section. The retaining member maintains the needle holder at the distal end of the barrel against the bias of the resilient member. When the plunger is fully depressed within the barrel, the plunger engages the needle holder such that the retaining member is forced to break away and separate from the needle holder along the reduced material section to facilitate retraction of the needle holder and a needle secured to the needle holder into the retraction cavity disposed within the plunger.

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of fibroblast growth factor receptor 4 (FGFR4). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding fibroblast growth factor receptor 4. Methods of using these compounds for modulation of fibroblast growth factor receptor 4 expression and for treatment of diseases associated with expression of fibroblast growth factor receptor 4 are provided.