Patents by Inventor Xian-Cheng Jiang

Xian-Cheng Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay for phospholipid transfer protein (PLTP) activity
    Patent number: 7618784
    Abstract: Improved methods for assaying the activity of phospholipid transfer protein (PLTP) enhance the signal-to-noise ratio by providing the substrate in donor particles with an aqueous core in the presence of suitable osmotic pressure.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: November 17, 2009
    Assignee: Roar Holding LLC
    Inventors: Robert W. Brocia, Xian-Cheng Jiang
  • SERINE PALMITOYLCOA TRANSFERASE (SPT) INHIBITION BY MYRIOCIN OR GENETIC DEFICIENCY DECREASES CHOLESTEROL ABSORPTION
    Publication number: 20090264528
    Abstract: A first aspect of the invention provides a method of screening cholesterol absorption inhibitors, including: administering to a mammal a biologically effective amount of a candidate SPT inhibitor; and determining whether an amount at least one cholesterol absorption indicator protein in the intestine has changed after the administering step.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 22, 2009
    Applicant: The Research Foundation of State University of New York
    Inventors: Xian-Cheng Jiang, Zhiqiang Li
  • SPHINGOMYELIN SYNTHASE 2 (SMS2) DEFICIENCY ATTENUATES NFkB ACTIVATION, A POTENTIAL ANTI-ATHEROGENIC PROPERTY
    Publication number: 20090264514
    Abstract: The present invention is directed to a method of screening for NF?B inhibiting agents, the method including the steps of administering a biologically effective amount of a candidate SMS2 inhibitor to at least one cell; and determining whether the candidate SMS2 inhibitor inhibits NF?B.
    Type: Application
    Filed: April 20, 2009
    Publication date: October 22, 2009
    Applicant: The Research Foundation of State University of New York
    Inventors: Xian-Cheng Jiang, Tiruneh K. Hallemariam
  • ENZYMATIC METHODS FOR MEASURING PLASMA AND TISSUE SPHINGOMYLELIN AND PHOSPHATIDYLCHOLINE
    Publication number: 20090148877
    Abstract: A method for measuring sphingomyelin and phosphatidylcholine comprising incubating sphingomyelin and phosphatidylcholine with bacterial sphingomyelinase and bacterial phospholipase D, alkaline phosphatase, choline oxidase, peroxidase, N-Ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline, and 4-aminoantipyrine, preferably for about 45 minutes. A blue dye is generated.
    Type: Application
    Filed: December 13, 2006
    Publication date: June 11, 2009
    Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
    Inventors: Xian-Cheng Jiang, Mohammad Reza Hojjati
  • Animal Model for Studying Atherosclerotic Lesions
    Publication number: 20080249174
    Abstract: The present invention provides an animal model for atherosclerosis and a transgenic knockout animal. Methods for preventing and/or treating atherosclerosis are also provided. More specifically, the present invention provides methods of preventing and/or treating atherosclerosis by administering to a subject in need thereof an inhibitor of Serine palmitoyl-CoA transferase (SPT) or its subunit.
    Type: Application
    Filed: September 7, 2006
    Publication date: October 9, 2008
    Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
    Inventors: Xian-Cheng Jiang, Mohammad Reza Hojjati
  • Plasma phospholipid transfer protein (PLTP) deficiency represents an anti-atherogenic state and PLTP inhibitor has anti-atherosclerosis action
    Patent number: 6953671
    Abstract: This invention provides methods of decreasing apolipoprotein B-containing lipoprotein and of treating atherosclerotic diseases and dyslipidemic diseases by reducing plasma phospholipid transfer protein activity, and methods of identifying chemical compounds for use in such treatments.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: October 11, 2005
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Xian-Cheng Jiang, Alan R. Tall
  • Assay for phospholipid transfer protein (PLTP) activity
    Publication number: 20030235859
    Abstract: Improved methods for assaying the activity of phospholipid transfer protein (PLTP) enhance the signal-to-noise ratio by providing the substrate in donor particles with an aqueous core in the presence of suitable osmotic pressure.
    Type: Application
    Filed: October 23, 2002
    Publication date: December 25, 2003
    Inventors: Robert W. Brocia, Xian-Cheng Jiang
  • Plasma phospholipid transfer protein (PLTP) deficiency represents an anti-atherogenic state and PLTP inhibitor has anti-atherosclerosis action
    Publication number: 20020142280
    Abstract: This invention provides methods of decreasing apolipoprotein B-containing lipoprotein and of treating atherosclerotic diseases and dyslipidemic diseases by reducing plasma phospholipid transfer protein activity, and methods of identifying chemical compounds for use in such treatments.
    Type: Application
    Filed: February 23, 2001
    Publication date: October 3, 2002
    Inventors: Xian-Cheng Jiang, Alan R. Tall