Patents by Inventor Xianchi DONG

Xianchi DONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED INTEGRIN POLYPEPTIDES, MODIFIED INTEGRIN POLYPEPTIDE DIMERS, AND USES THEREOF
    Publication number: 20240117006
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Application
    Filed: September 29, 2023
    Publication date: April 11, 2024
    Applicant: The Children's Medical Center Corporation
    Inventors: Timothy Alan Springer, Xianchi Dong, Chafen Lu
  • COMPUTATIONAL DESIGN OF ALPHA(V) BETA (6) INTEGRIN BINDING PROTEINS
    Publication number: 20220348609
    Abstract: Alpha(v) beta (6) integrin (avb6) binding polypeptides are disclosed herein, and their use in treating and detecting tumors, and their use in treating pulmonary fibrosis.
    Type: Application
    Filed: October 23, 2020
    Publication date: November 3, 2022
    Inventors: Anindya Roy, Lei Shi, Xianchi Dong, Jing Li, Timothy Springer, David Baker
  • MODIFIED INTEGRIN POLYPEPTIDES, MODIFIED INTEGRIN POLYPEPTIDE DIMERS, AND USES THEREOF
    Publication number: 20220064261
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Application
    Filed: July 23, 2021
    Publication date: March 3, 2022
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan SPRINGER, Xianchi Dong, Chafen Lu
  • Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereof
    Patent number: 11104713
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: August 31, 2021
    Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan Springer, Xianchi Dong, Chafen Lu
  • MODIFIED INTEGRIN POLYPEPTIDES, MODIFIED INTEGRIN POLYPEPTIDE DIMERS, AND USES THEREOF
    Publication number: 20200031900
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Application
    Filed: March 8, 2019
    Publication date: January 30, 2020
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan SPRINGER, Xianchi DONG, Chafen LU
  • Modified integrin polypeptides, modified integrin polypeptide dimers, and uses thereof
    Patent number: 10273283
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: April 30, 2019
    Assignee: The Children's Medical Center Corporation
    Inventors: Timothy Alan Springer, Xianchi Dong, Chafen Lu
  • MODIFIED INTEGRIN POLYPEPTIDES, MODIFIED INTEGRIN POLYPEPTIDE DIMERS, AND USES THEREOF
    Publication number: 20170183390
    Abstract: Described herein are modified integrin ? and/or ? headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin ? and/or ? headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin ? and/or ? headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins.
    Type: Application
    Filed: February 3, 2017
    Publication date: June 29, 2017
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Timothy Alan SPRINGER, Xianchi DONG, Chafen LU