Patents by Inventor Xianfeng Lin

Xianfeng Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL PYRAZOLOPYRAZINE AND TRIAZOLOPYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES
    Publication number: 20190248792
    Abstract: The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 and Q are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
    Type: Application
    Filed: January 14, 2019
    Publication date: August 15, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Xingchun Han, Xianfeng Lin, Hong Shen, Taishan Hu, Zhisen Zhang
  • PYRIDAZINONE-BASED BROAD SPECTRUM ANTI-INFLUENZA INHIBITORS
    Publication number: 20190127349
    Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
    Type: Application
    Filed: December 19, 2018
    Publication date: May 2, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: John G. CUMMING, Xianfeng LIN, Haixia LIU, Isabel NAJERA, Zongxing QIU, Virginie SANDRIN, Guozhi TANG, Guolong WU
  • Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20180370969
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 14, 2018
    Publication date: December 27, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
    Publication number: 20180327425
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 30, 2018
    Publication date: November 15, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Yimin Hu, Chengang Zhou, Mingwei Zhou, Houguang Shi, Yongqiang Liu, Hong Shen, Maarten Vercruysse, Shixiang Yan, Xuefei Tan, Xianfeng Lin, Fabian Dey
  • 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 10081627
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: September 25, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • 4-methyl-dihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection
    Patent number: 9856247
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, M and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: January 2, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Xianfeng Lin, Haixia Liu, Zongxing Qiu, Hong Sheng, Guozhi Tang, Guolong Wu, Weixing Zhang, Wei Zhu
  • NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20170334898
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, M and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 28, 2015
    Publication date: November 23, 2017
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Xianfeng Lin, Haixia Liu, Zongxing Qiu, Hong Sheng, Guozhi Tang, Guolong Wu, Weixing Zhang, Wei Zhu
  • 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9758530
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: September 12, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Buyu Kou, Gangqin Li, Xianfeng Lin, Haixia Liu, Hong Shen, Houguang Shi, Guolong Wu, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9447086
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: September 20, 2016
    Assignee: Hoffmann-LA Roche INC.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Xianfeng Lin, Haixia Liu, Alexander V Mayweg, Zongxing Qiu, Hong Shen, Guozhi Tang, Lisha Wang, Guolong Wu, Shixiang Yan, Weixing Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20160237078
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 10, 2013
    Publication date: August 18, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Xianfeng Lin, Haixia Liu, Alexander V Mayweg, Zongxing Qiu, Hong Shen, Guozhi Tang, Lisha Wang, Guolong Wu, Shixiang Yan, Weixing Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20160122363
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: January 8, 2016
    Publication date: May 5, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Buyu Kou, Gangqin Li, Xianfeng Lin, Haixia Liu, Hong Shen, Houguang Shi, Guolong Wu, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20160083383
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 24, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20160052921
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, M and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 28, 2015
    Publication date: February 25, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Xianfeng Lin, Haixia Liu, Zongxing Qiu, Hong Sheng, Guozhi Tang, Guolong Wu, Weixing Zhang, Wei Zhu
  • 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9266904
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: February 23, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Buyu Kou, Gangqin Li, Xianfeng Lin, Haixia Liu, Hong Shen, Houguang Shi, Guolong Wu, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Patent number: 9233978
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: January 12, 2016
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20150252057
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 6, 2015
    Publication date: September 10, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Buyu Kou, Xianfeng Lin, Hong Shen, Houguang Shi, Shixiang Yan, Weixing Zhang, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • Novel 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
    Publication number: 20150031687
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 10, 2013
    Publication date: January 29, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Xianfeng Lin, Haixia Liu, Alexander V Mayweg, Zongxing Qiu, Hong Shen, Guozhi Tang, Lisha Wang, Guolong Wu, Shixiang Yan, Weixing Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20140343032
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 16, 2014
    Publication date: November 20, 2014
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lei Guo, Taishan Hu, Yimin Hu, Buelent Kocer, Buyu Kou, Gangqin Li, Xianfeng Lin, Haixia Liu, Hong Shen, Houguang Shi, Guolong Wu, Zhisen Zhang, Mingwei Zhou, Wei Zhu
  • NOVEL 4-METHYL-DIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20130267517
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, M and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 10, 2013
    Inventors: Lei Guo, Xianfeng Lin, Haixia Liu, Zongxing Qiu, Hong Sheng, Guozhi Tang, Guolong Wu, Weixing Zhang, Wei Zhu
  • 4-amino-N-hydroxy-benzamides for the treatment of cancer
    Patent number: 8404738
    Abstract: The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: March 26, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Xianfeng Lin, Zongxing Qiu, Guozhi Tang, Jason Christopher Wong, Zhenshan Zhang