Patents by Inventor Xiang Ding

Xiang Ding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160024091
    Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
    Type: Application
    Filed: March 10, 2014
    Publication date: January 28, 2016
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Alexander Pasternak, Fa-Xiang Ding, Shuzhi Dong, Dipshikha Biswas, Haifeng Tang, Jinlong Jiang, Cangming Yang, Xin Gu
  • Publication number: 20160002259
    Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.
    Type: Application
    Filed: February 12, 2014
    Publication date: January 7, 2016
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Alexander Pasternak, Reynalda Keh DeJesus, Fa-Xiang Ding, Shuzhi Dong, Jessica L. Frie, Xin Gu, Jinlong Jiang, Aurash Shahripour, Barbara Pio, Haifeng Tang, Shawn Walsh
  • Patent number: 9206198
    Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: December 8, 2015
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Fa-Xiang Ding, Shuzhi Dong, Jessica Frie, Xin Gu, Jinlong Jiang, Alexander Pasternak, Haifeng Tang, Zhicai Wu, Yang Yu, Takao Suzuki
  • Patent number: 9062070
    Abstract: The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: June 23, 2015
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Alexander Pasternak, Timothy Blizzard, Harry Chobanian, Reynalda de Jesus, Fa-Xiang Ding, Shuzhi Dong, Candido Gude, Dooseop Kim, Haifeng Tang, Shawn Walsh, Barbara Pio, Jinlong Jiang
  • Publication number: 20150099729
    Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Fa-Xiang Ding, Shuzhi Dong, Jessica Frie, Xin Gu, Jinlong Jiang, Alexander Pasternak, Haifeng Tang, Zhicai Wu, Yang Yu, Takao Suzuki
  • Patent number: 8952166
    Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: February 10, 2015
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Fa-Xiang Ding, Shuzhi Dong, Jessica Frie, Xin Gu, Jinlong Jiang, Alexander Pasternak, Haifeng Tang, Zhicai Wu, Yang Yu, Takao Suzuki
  • Publication number: 20140206618
    Abstract: The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
    Type: Application
    Filed: August 16, 2012
    Publication date: July 24, 2014
    Inventors: Alexander Pasternak, Timothy Blizzard, Harry Chobanian, Reynalda de Jesus, Fa-Xiang Ding, Shuzhi Dong, Candido Gude, Dooseop Kim, Haifeng Tang, Shawn Walsh, Barbara Pio, Jinlong Jiang
  • Patent number: 8785634
    Abstract: Compounds of structural formula (I) are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: July 22, 2014
    Assignee: Merck Sharp & Dohme Corp
    Inventors: Fa-Xiang Ding, JinLong Jiang, Dong-Ming Shen, Hong Shen, Zhi-Cai Shi
  • Publication number: 20140031349
    Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
    Type: Application
    Filed: July 25, 2013
    Publication date: January 30, 2014
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Fa-Xiang Ding, Shuzhi Dong, Jessica Frie, Xin Gu, Jinlong Jiang, Alexander Pasternak, Haifeng Tang, Zhicai Wu, Yang Yu, Takao Suzuki
  • Patent number: 8455520
    Abstract: Compounds of the Formula: (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating hypertension, diabetes, inflammation, atherosclerosis, pain, and the like are disclosed. Pharmaceutical compositions and methods of use are also included.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: June 4, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Steven L. Colletti, Hong Shen, Fa-Xiang Ding
  • Publication number: 20130059830
    Abstract: Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
    Type: Application
    Filed: May 16, 2011
    Publication date: March 7, 2013
    Inventors: Fa-Xiang Ding, Jinlong Jiang, Dong-Ming Shen, Zhi-Cai Shi, Min Shu, Cangming Yang
  • Publication number: 20130023515
    Abstract: Compounds of structural formula (I) are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
    Type: Application
    Filed: April 21, 2011
    Publication date: January 24, 2013
    Inventors: Fa-Xiang Ding, Jinlong Jiang, Dong-Ming Shen, Hong Shen, Zhi-Cai Shi
  • Publication number: 20130012511
    Abstract: The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
    Type: Application
    Filed: March 22, 2011
    Publication date: January 10, 2013
    Inventors: Darby Schmidt, Subharekha Raghavan, John Stelmach, Jian Guo, Jonathan Groeper, Linda Brockunier, Keith Rosauer, Hong Shen, Rui Liang, Fa-Xiang Ding
  • Patent number: 8339779
    Abstract: An electronic device includes a main body, a card holder assembly, and a card holder control assembly. The card holder assembly includes a shaft secured within the main body, at least one torsion spring, and at least one card holder. The torsion spring is arranged over the shaft. One end of each torsion spring is secured to the shaft, and an opposite end is secured to one card holder. When the card holder is secured within the main body, the torsion spring is in a compressed state. The card holder is rotatably fixed in place on the shaft. The control assembly includes a switch, a pulling rod, and at least one latching member. The switch is slidably connected to the main body and moveable between a first position and a second position. The latching member is connected to the pulling rod.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: December 25, 2012
    Assignees: Fu Tai Hua Industry (Shenzhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.
    Inventor: You-Xiang Ding
  • Publication number: 20120178750
    Abstract: The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Application
    Filed: March 19, 2012
    Publication date: July 12, 2012
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Subharekha Raghavan, Steven L. Colletti, Fa-Xiang Ding, Hong Shen, James R. Tata, Ashley Rouse Lins, Abigail Lee Smenton, Weichun Chen, Darby Rye Schmidt, George Scott Tria
  • Patent number: 8168649
    Abstract: The present invention encompasses compounds of Formula (I): as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: May 1, 2012
    Assignee: Merk Sharp & Dohme Corp.
    Inventors: Subharekha Raghavan, Steven L. Colletti, Fa-Xiang Ding, Hong Shen, James R. Tata, Ashley Rouse Lins, Abigail Lee Smenton, Weichun Chen, Darby Rye Schmidt, George Scott Tria
  • Publication number: 20120087068
    Abstract: An electronic device includes a main body, a card holder assembly, and a card holder control assembly. The card holder assembly includes a shaft secured within the main body, at least one torsion spring, and at least one card holder. The torsion spring is arranged over the shaft. One end of each torsion spring is secured to the shaft, and an opposite end is secured to one card holder. When the card holder is secured within the main body, the torsion spring is in a compressed state. The card holder is rotatably fixed in place on the shaft. The control assembly includes a switch, a pulling rod, and at least one latching member. The switch is slidably connected to the main body and moveable between a first position and a second position. The latching member is connected to the pulling rod.
    Type: Application
    Filed: October 27, 2010
    Publication date: April 12, 2012
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., FU TAI HUA INDUSTRY (SHENZHEN) CO., LTD.
    Inventor: YOU-XIANG DING
  • Patent number: 8113020
    Abstract: A lock includes a housing, a cover, a lock cylinder holder, a lock cylinder, a cam, a resisting shaft, at least one latching block, and at least one first elastic member. The cover is secured to one end of the housing. A gap is formed between the cover and the housing. The lock cylinder holder is secured to the housing. The lock cylinder is rotatably mounted in the lock cylinder holder. The cam is received in the housing and secured to the lock cylinder. The resisting shaft is rotatably mounted in the housing and includes a frustum shaped end. The latching block is received in the gap. The latching block includes an inclined surface corresponding to the frustum shaped end. The first elastic member is configured to connect the latching block to the cover or the housing. An electronic device using the lock is also provided.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: February 14, 2012
    Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.
    Inventors: Yu-Rong Liu, Xiao-Feng Yang, You-Xiang Ding
  • Patent number: 8105090
    Abstract: An electrical connector assembly includes a socket and a plug. The socket includes a first main body defining a first longitudinal receiving space. A sidewall of the first longitudinal receiving space defines a helical slot. The helical slot includes at least one entrance formed on an end of the first longitudinal receiving space. The plug includes a second main body and at least one fixing assembly mounted in a peripheral sidewall of the second main body. Each of the at least one fixing assembly includes a ball rotatably connected to and extends partially out of the peripheral sidewall of the second main body. The extending part of the at least one ball being is able to slide in the helical slot through the at least one entrance.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: January 31, 2012
    Assignees: Fu Tai Hua Industry (Shenzhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.
    Inventor: You-Xiang Ding
  • Publication number: 20110161211
    Abstract: A method and a system provide real-time payment fund settlement of a logistics company using a third-party payment platform, which signs a withholding agreement with the logistics company and a logistics agency and establishes separate payment accounts for the logistics company and the logistics agency. The logistics company sends a withholding instruction to the third-party payment platform upon receiving signature information and goods information sent by the courier after the buyer has made a payment and signed for the acceptance of the goods. After receiving the withholding instruction, the third-party payment platform verifies the withholding instruction based on the withholding agreement, and transfers a fund from the payment account of the logistics agency to the payment account of the logistics company. The disclosed method and system can greatly increase the speed of fund transfer and fund settlement between the logistics company and the logistics agency.
    Type: Application
    Filed: September 15, 2009
    Publication date: June 30, 2011
    Applicant: Alibaba Group Holding Limited
    Inventors: Zhenghua Zhang, Xiang Ding