Abstract: There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided.

Abstract: A method for reinforcing soft ground by post-grouting combined with pressurized vacuum preloading is proposed, by pre-burying prefabricated vertical drains and air-boosted pipes in granular material piles, and the air-boosted pipes are used as grouting pipes to reduce the number of times of piling, which not only improves the construction efficiency, but also reduces the structural disturbance of the soil and the influence of smear effect, thus reducing the impact on the radial permeability and the radial consolidation coefficients. The method does not use geotextile bags for granular materials, which can avoid the problem of forming a localized clogging area around the geotextile bags, and the method not only improves the efficiency of vacuum transfer in a pre-consolidation stage, but also improves the grouting effect in the later stage, effectively enhances the strength of soft soil and makes granular material piles and the surrounding soil form composite ground.

Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: A translation model based training method is provided for a computer device. The method includes inputting a source sentence to a translation model, to obtain a target sentence outputted by the translation model; determining a fidelity of the target sentence to the source sentence; using the target sentence and a reference sentence as input of a discriminator model, using the fidelity as output of the discriminator model, and training the discriminator model on a performance of calculating a similarity between the target sentence and the reference sentence; outputting the similarity by using the discriminator model; and using the source sentence as input of the translation model, using the target sentence as output of the translation model, and using the similarity as a weight coefficient, and training the translation model on a performance of outputting the corresponding target sentence according to the input source sentence.

Abstract: A translation model based training method is provided for a computer device. The method includes inputting a source sentence to a translation model, to obtain a target sentence outputted by the translation model; determining a fidelity of the target sentence to the source sentence; using the target sentence and a reference sentence as input of a discriminator model, using the fidelity as output of the discriminator model, and training the discriminator model on a performance of calculating a similarity between the target sentence and the reference sentence; outputting the similarity by using the discriminator model; and using the source sentence as input of the translation model, using the target sentence as output of the translation model, and using the similarity as a weight coefficient, and training the translation model on a performance of outputting the corresponding target sentence according to the input source sentence.

Abstract: A system and method for automated adjustment processing using pre-configured sets of business rules is provided. The seller pre-configures a set of business rules for use in processing an adjustment for a specific buyer. The set of business rules may be variable for each buyer and/or globally set. When a payment is received from a seller and an adjustment is required, an adjustment management application retrieves the buyer's set of business rules from the seller. The set of business rules are then applied to attempt to match the received payment to one of the buyer's outstanding invoices. If the match is successful, the buyer's payment is processed.

Abstract: The present invention relates to a control technology of a three-phase DC motor. In order to resolve a problem in the prior art that the good current closed-loop control has not been realized on a three-phase square-wave brushless DC motor, the present invention provides a brushless DC motor control system, wherein cathodes of freewheel diodes D1, D3 and D5 are independent of input terminals of their respective switch tubes and connected in parallel to a sampling coil L1, and anodes of freewheel diodes D4, D6 and D2 are independent of output terminals of their respective switch tubes and connected in parallel to a sampling coil L2. The present invention can use a single resultant current sensor to completely and continuously sample the three-phase current existing during the motor is on and performs current freewheel, and perform the continuous closed-loop control on the three-phase current with a single current closed-loop regulator, thereby increasing dynamic and static indexes of the motor significantly.

Abstract: This invention relates to a three-phase square-wave permanent magnet brushless DC motor for solving problems of the existing square-wave permanent Magnet Motor and sine-wave permanent magnet motor. In this invention, the number 2P of magnetic poles on the said rotor core is 8; the slot number Z of the said stator core is 12, accordingly there are 12 teeth, including three big teeth, three medium teeth and six small teeth; the ratio of their mechanical angles is 50° (±5°) for big teeth: 40° (±5°) for medium teeth: 15° (±5°) for small teeth, and the sum of the mechanical angles of one big tooth, one medium tooth and two small teeth must be 120°. Three-phase concentrated windings are respectively wound on the big teeth and the medium teeth, in which there are only two concentrated windings for each phase, thus there are only 6 concentrated windings for the three-phase motor.

Abstract: The present invention relates to a control technology of a three-phase DC motor. In order to resolve a problem in the prior art that the good current closed-loop control has not been realized on a three-phase square-wave brushless DC motor, the present invention provides a brushless DC motor control system, wherein cathodes of freewheel diodes D1, D3 and D5 are independent of input terminals of their respective switch tubes and connected in parallel to a sampling coil L1, and anodes of freewheel diodes D4, D6 and D2 are independent of output terminals of their respective switch tubes and connected in parallel to a sampling coil L2. The present invention can use a single resultant current sensor to completely and continuously sample the three-phase current existing during the motor is on and performs current freewheel, and perform the continuous closed-loop control on the three-phase current with a single current closed-loop regulator, thereby increasing dynamic and static indexes of the motor significantly.

Abstract: This invention relates to a three-phase square-wave permanent magnet brushless DC motor for solving problems of the existing square-wave permanent Magnet Motor and sine-wave permanent magnet motor. In this invention, the number 2P of magnetic poles on the said rotor core is 8; the slot number Z of the said stator core is 12, accordingly there are 12 teeth, including three big teeth, three medium teeth and six small teeth; the ratio of their mechanical angles is 50° (±5°) for big teeth: 40° (±5°) for medium teeth: 15° (±5°) for small teeth, and the sum of the mechanical angles of one big tooth, one medium tooth and two small teeth must be 120°. Three-phase concentrated windings are respectively wound on the big teeth and the medium teeth, in which there are only two concentrated windings for each phase, thus there are only 6 concentrated windings for the three-phase motor.

Abstract: A system and method for automated adjustment processing using pre-configured sets of business rules is provided. The seller pre-configures a set of business rules for use in processing an adjustment for a specific buyer. The set of business rules may be variable for each buyer and/or globally set. When a payment is received from a seller and an adjustment is required, an adjustment management application retrieves the buyer's set of business rules from the seller. The set of business rules are then applied to attempt to match the received payment to one of the buyer's outstanding invoices. If the match is successful, the buyer's payment is processed.

Abstract: A system and method for automated adjustment processing using pre-configured sets of business rules is provided. The seller pre-configures a set of business rules for use in processing an adjustment for a specific buyer. The set of business rules may be variable for each buyer and/or globally set. When a payment is received from a seller and an adjustment is required, an adjustment management application retrieves the buyer's set of business rules from the seller. The set of business rules are then applied to attempt to match the received payment to one of the buyer's outstanding invoices. If the match is successful, the buyer's payment is processed.

Abstract: A system and method for automated adjustment processing using pre-configured sets of business rules is provided. The seller pre-configures a set of business rules for use in processing an adjustment for a specific buyer. The set of business rules may be variable for each buyer and/or globally set. When a payment is received from a seller and an adjustment is required, an adjustment management application retrieves the buyer's set of business rules from the seller. The set of business rules are then applied to attempt to match the received payment to one of the buyer's outstanding invoices. If the match is successful, the buyer's payment is processed.

Abstract: A system and method for seller-assisted automated payment and adjustment processing is provided. A seller receives a payment from a buyer that does not match the seller's invoice and consequently requires an adjustment. An adjustment document creator receives the payment data from the buyer and retrieves buyer-specific order data from said seller to construct an adjustment document. A variety of adjustment documents may be created depending upon the actual adjustment required. The adjustment document may then be automatically routed to a set of one or more buyer-specific human reviewers for approval of the adjustment. The automated payment and adjustment processing system is preferably integrated with the seller's financial institution.

Abstract: A system and method for automated incoming payment and invoice reconciliation is provided. A buyer of goods sends a remittance to the seller's financial institution. The buyer's remittances is processed to generate payment data which is supplied to a payment matching application. The payment matching application retrieves buyer information from said payment data and queries the seller for all outstanding invoices of said buyer. The payment matching application then attempts to match the received payment to one or more of the buyer's outstanding invoices. If a match is found, the payment is processed and the seller's financial institution and accounting system are automatically updated. If no match is found, the payment is flagged for further processing.

Abstract: A system and method for automated adjustment processing using pre-configured sets of business rules is provided. The seller pre-configures a set of business rules for use in processing an adjustment for a specific buyer. The set of business rules may be variable for each buyer and/or globally set. When a payment is received from a seller and an adjustment is required, an adjustment management application retrieves the buyer's set of business rules from the seller. The set of business rules are then applied to attempt to match the received payment to one of the buyer's outstanding invoices. If the match is successful, the buyer's payment is processed.