Abstract: Methods, compositions and kits for detecting mutated aminoacyl tRNA synthetase (aaRS) in biological samples from a subject suspect of having or suffering from a Charcot-Marie-Tooth (CMT) disease or a CMT-related disease are disclosed herein. In some embodiments, the methods include determining the amount of mutated aaRS bound to Neuropilin 1 (Nrp1). In some embodiments, methods include detection of endogenous vascular endothelial growth factor (VEGF) bound to Nrp1. Also disclosed are methods, compositions and kits for the diagnosis of a CMT or a CMT-related disease through the detection of VEGF and/or mutated aaRS in a subject.

Abstract: Provided are compositions and methods for the treatment of mutant glycyl-tRNA synthetase (GlyRS)-associated diseases, such as Charcot-Marie-Tooth (CMT) diseases, and related compositions and methods for diagnostic, drug discovery, and research applications. Also provided are mutant glycyl-tRNA synthetases and uses thereof.

Abstract: Isolated monomeric aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.

Abstract: Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.

Abstract: Provided are histidyl-tRNA synthetase variant polypeptides, X-ray crystallographic and NMR spectroscopy structures of HRS polypeptides, and related compositions and methods for therapy and drug discovery.

Abstract: The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an ?5 coil; and (b) an anticodon recognition domain or portion thereof, preferably including an ?14 coil. Preferably, the ?5 coil and the ?14 coil have a greater spatial separation in the tertiary structure of the variant compared to the corresponding spatial separation in native human TyrRS. The variant preferably comprises an amino acid residue sequence identity of at least about 50% compared to the amino acid residue sequence of human TyrRS (SEQ ID NO: 3), includes at least one non-conservative amino acid residue substitution relative to the amino acid residue sequence of human TyrRS, and preferably presents an exposed ELR motif in the ?5 coil on an external portion of the tertiary structure of the polypeptide. A preferred TyrRS protein variant comprises the amino acid residue sequence of SEQ ID NO: 4 or a portion thereof.

Abstract: A baby carrier with an adjustable back plate comprises a main body, a back plate, a belt and a belt adjustment mechanism. The main body has a bottom wall, two long side walls and two short side walls. The back plate is pivoted on the bottom wall for support baby-occupant in a selected inclination. The belt has a distal end affixed to one side of the main body and an adjustable length for passing across underneath the back plate for retaining the back plate in the selected inclination angle. The belt adjustment mechanism is mounted on the opposite side of the main body for adjusting the adjustable length of the belt by pulling the free end thereof and pressing the back plate downwardly just under the instinct of the care-giver.

Abstract: Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.

Abstract: The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an ?5 coil; and (b) an anticodon recognition domain or portion thereof, preferably including an ?14 coil. Preferably, the ?5 coil and the ?14 coil have a greater spatial separation in the tertiary structure of the variant compared to the corresponding spatial separation in native human TyrRS. The variant preferably comprises an amino acid residue sequence identity of at least about 50% compared to the amino acid residue sequence of human TyrRS (SEQ ID NO: 3), includes at least one non-conservative amino acid residue substitution relative to the amino acid residue sequence of human TyrRS, and preferably presents an exposed ELR motif in the ?5 coil on an external portion of the tertiary structure of the polypeptide. A preferred TyrRS protein variant comprises the amino acid residue sequence of SEQ ID NO: 4 or a portion thereof.

Abstract: The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an 5 coil; and (b) an anticodon recognition domain or portion thereof, preferably including an 14 coil. Preferably, the 5 coil and the 14 coil have a greater spatial separation in the tertiary structure of the variant compared to the corresponding spatial separation in native human TyrRS. The variant preferably comprises an amino acid residue sequence identity of at least about 50% compared to the amino acid residue sequence of human TyrRS (SEQ ID NO: 3), includes at least one non-conservative amino acid residue sequence of human TyrRS, and preferably presents an exposed ELR motif in the 5 coil on an external portion of the tertiary structure of the polypeptide. A preferred TyrRS protein variant comprises the amino acid residue sequence of SEQ ID NO: 4 or a portion thereof.

Abstract: A baby carrier with an adjustable back plate comprises a main body, a back plate, a belt and a belt adjustment mechanism. The main body has a bottom wall, two long side walls and two short side walls. The back plate is pivoted on the bottom wall for support baby-occupant in a selected inclination. The belt has a distal end affixed to one side of the main body and an adjustable length for passing across underneath the back plate for retaining the back plate in the selected inclination angle. The belt adjustment mechanism is mounted on the opposite side of the main body for adjusting the adjustable length of the belt by pulling the free end thereof and pressing the back plate downwardly just under the instinct of the care-giver.

Abstract: A floor panel with coupling devices is provided. The coupling devices have locking elements which include a curved protrusion which is formed on a lower wall of an upper lip of a groove and adjacent to the entrance of the groove, and a curved recess which is formed in an upper side of a tongue and can match with the curved protrusion. Under the cooperation of the elastic deformation of the upper lip of the groove and the engagement of the locking elements, adjacent floor panels can be coupled together by exerting on them a horizontal pressing force and interlocked tightly by meshing engagement of the curved protrusion at the groove and the curved recess in the tongue without glue or other auxiliary binding material so as to ensure that the adjacent floor panels can not move in both horizontal direction and vertical direction. The floor panels are usually used in a floor decoration of indoor environment and have the advantages of easy installation and tight coupling.

Abstract: A floor panel with coupling devices is provided. The coupling devices have locking elements which include a curved protrusion which is formed on a lower wall of an upper lip of a groove and adjacent to the entrance of the groove, and a curved recess which is formed in an upper side of a tongue and can match with the curved protrusion. Under the cooperation of the elastic deformation of the upper lip of the groove and the engagement of the locking elements, adjacent floor panels can be coupled together by exerting on them a horizontal pressing force and interlocked tightly by meshing engagement of the curved protrusion at the groove and the curved recess in the tongue without glue or other auxiliary binding material so as to ensure that the adjacent floor panels can not move in both horizontal direction and vertical direction. The floor panels are usually used in a floor decoration of indoor environment and have the advantages of easy installation and tight coupling.

Abstract: The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an 5 coil; and (b) an anticodon recognition domain or portion thereof, preferably including an 14 coil. Preferably, the 5 coil and the 14 coil have a greater spatial separation in the tertiary structure of the variant compared to the corresponding spatial separation in native human TyrRS. The variant preferably comprises an amino acid residue sequence identity of at least about 50% compared to the amino acid residue sequence of human TyrRS (SEQ ID NO: 3), includes at least one non-conservative amino acid residue sequence of human TyrRS, and preferably presents an exposed ELR motif in the 5 coil on an external portion of the tertiary structure of the polypeptide. A preferred TyrRS protein variant comprises the amino acid residue sequence of SEQ ID NO: 4 or a portion thereof.