Abstract: Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens include natural and consensus V3 sequences and cyclic and reverse peptides. Preferred scaffold proteins are Cholera Toxin subunit B and homologues thereof including closely related E. coli enterotoxins. Such immunogenic polypeptides induce broadly reactive anti-gp120 antibodies specific for V3 epitopes that can neutralize heterologous HIV-1 subtypes and strains. These polypeptide, methods for preparing them, and methods for inducing anti-gp120 (V3-specific) antibody) responses using them are disclosed.

Abstract: The present invention discloses a power control method and apparatus. The power control method of the present invention includes: when a service runs in a first-standard communication system, determining a transmit power P1 of the first-standard communication system; determining that the transmit power P1 is higher than or equal to a threshold value P2 of power interference of the first-standard communication system to a second-standard communication system; use a power lower than P1 to send data on an interference frequency of the first-standard communication system. According to the power control method in the present invention, a signal transmit power of the interfering frequency of the first-standard communication system can be reduced when it is determined that the first-standard communication system will cause interference to the second-standard communication system, thereby reducing the interference of the first-standard communication system to the second-standard communication system.

Abstract: Systems and methods of high efficiency amplification of pulsed laser output for high energy ultra-short pulse laser systems are provided herein. According to some embodiments, methods for amplifying pulsed laser output for high energy ultra-short pulse laser systems include receiving pulsed laser output and amplifying the pulsed laser output by propagating the pulsed laser output through a non-silica based gain medium that has been doped with a concentration of rare earth ions, wherein the concentration of the rare earth ions within the gain medium is approximately greater than one percent by weight.

Abstract: Various embodiments described include optical fiber designs and fabrication processes for ultra high numerical aperture optical fibers (UHNAF) having a numerical aperture (NA) of about 1. Various embodiments of UHNAF may have an NA greater than about 0.7, greater than about 0.8, greater than about 0.9, or greater than about 0.95. Embodiments of UHNAF may have a small core diameter and may have low transmission loss. Embodiments of UHNAF having a sufficiently small core diameter provide single mode operation. Some embodiments have a low V number, for example, less than 2.4 and large dispersion. Some embodiments of UHNAF have extremely large negative dispersion, for example, less than about ?300 ps/nm/km in some embodiments. Systems and apparatus using UHNAF are also disclosed.

Abstract: The present invention discloses a power control method, apparatus, and system. The power control method of the present invention includes: when a service runs in a first-standard communication system, determining a transmit power P1 of the first-standard communication system; determining that the transmit power P1 is higher than or equal to a threshold value P2 of power interference of the first-standard communication system to a second-standard communication system; use a power lower than P1 to send data on an interference frequency of the first-standard communication system. According to the power control method in the present invention, a signal transmit power of the interfering frequency of the first-standard communication system can be reduced when it is determined that the first-standard communication system will cause interference to the second-standard communication system, thereby reducing the interference of the first-standard communication system to the second-standard communication system.

Abstract: Various embodiments described herein include rare earth doped glass compositions that may be used in optical fiber and rods having large core sizes. Such optical fibers and rods may be employed in fiber lasers and amplifiers. The index of refraction of the glass may be substantially uniform and may be close to that of silica in some embodiments. Possible advantages to such features include reduction of formation of additional waveguides within the core, which becomes increasingly a problem with larger core sizes.

Abstract: A hybrid waveguide device includes a hollow core fiber having a core formed by a combination of solid material and gases. The hybrid nature of the core allows the hybrid device to transport a high energy high power laser beam having an ultra-short pulse width without damage to the hybrid device due to a higher tolerance of irradiance than single-matter cores. A waveguide device having a core with gases in addition to solid matter is characterized by a lower nonlinear refractive index coefficient (n2), lower numerical aperture, larger delivering laser beam size, and higher ionization potential of the gases. As a result, the hybrid waveguide fiber can transport ultra-short laser pulses having ablative energy levels and power levels, for example from a laser generating subassembly to a laser material-modification subassembly.

Abstract: Various embodiments described herein include rare earth doped glass compositions that may be used in optical fiber and rods having large core sizes. Such optical fibers and rods may be employed in fiber lasers and amplifiers. The index of refraction of the glass may be substantially uniform and may be close to that of silica in some embodiments. Possible advantages to such features include reduction of formation of additional waveguides within the core, which becomes increasingly a problem with larger core sizes.

Abstract: Various embodiments described include optical fiber designs and fabrication processes for ultra high numerical aperture optical fibers (UHNAF) having a numerical aperture (NA) of about 1. Various embodiments of UHNAF may have an NA greater than about 0.7, greater than about 0.8, greater than about 0.9, or greater than about 0.95. Embodiments of UHNAF may have a small core diameter and may have low transmission loss. Embodiments of UHNAF having a sufficiently small core diameter provide single mode operation. Some embodiments have a low V number, for example, less than 2.4 and large dispersion. Some embodiments of UHNAF have extremely large negative dispersion, for example, less than about ?300 ps/nm/km in some embodiments. Systems and apparatus using UHNAF are also disclosed.

Abstract: Updating an Internet Protocol (IP) address database includes: obtaining transaction address data from a transaction information database, the transaction address data including IP address information and geographical address information received during user transactions; processing the transaction address data to identify specific transaction address data that have overlapping geographical address information and contiguous IP addresses; and updating the IP address database according to the overlapping geographical address information and the contiguous IP addresses.

Abstract: Various embodiments described include optical fiber designs and fabrication processes for ultra high numerical aperture optical fibers (UHNAF) having a numerical aperture (NA) of about 1. Various embodiments of UHNAF may have an NA greater than about 0.7, greater than about 0.8, greater than about 0.9, or greater than about 0.95. Embodiments of UHNAF may have a small core diameter and may have low transmission loss. Embodiments of UHNAF having a sufficiently small core diameter provide single mode operation. Some embodiments have a low V number, for example, less than 2.4 and large dispersion. Some embodiments of UHNAF have extremely large negative dispersion, for example, less than about ?300 ps/nm/km in some embodiments. Systems and apparatus using UHNAF are also disclosed.

Abstract: Various embodiments described herein include rare earth doped glass compositions that may be used in optical fiber and rods having large core sizes. Such optical fibers and rods may be employed in fiber lasers and amplifiers. The index of refraction of the glass may be substantially uniform and may be close to that of silica in some embodiments. Possible advantages to such features include reduction of formation of additional waveguides within the core, which becomes increasingly a problem with larger core sizes.

Abstract: Various embodiments described herein include rare earth doped glass compositions that may be used in optical fiber and rods having large core sizes. Such optical fibers and rods may be employed in fiber lasers and amplifiers. The index of refraction of the glass may be substantially uniform and may be close to that of silica in some embodiments. Possible advantages to such features include reduction of formation of additional waveguides within the core, which becomes increasingly a problem with larger core sizes.

Abstract: Various embodiments described include optical fiber designs and fabrication processes for ultra high numerical aperture optical fibers (UHNAF) having a numerical aperture (NA) of about 1. Various embodiments of UHNAF may have an NA greater than about 0.7, greater than about 0.8, greater than about 0.9, or greater than about 0.95. Embodiments of UHNAF may have a small core diameter and may have low transmission loss. Embodiments of UHNAF having a sufficiently small core diameter provide single mode operation. Some embodiments have a low V number, for example, less than 2.4 and large dispersion. Some embodiments of UHNAF have extremely large negative dispersion, for example, less than about ?300 ps/nm/km in some embodiments. Systems and apparatus using UHNAF are also disclosed.

Abstract: The present invention provides a sensitive fluorimetric indicator for analytes determination in the oxygen-insensitive DT-diaphorase-coupled dehydrogenases assay by omitting NADH, which is generated by reaction in the presence of analytes, which presents to the applicability as a biosensor for future clinical diagnostic. Furthermore, the novel long-wavelength latent fluorimetric indicator is also a user-friendly probe for monitoring DT-diaphorase activity. The fluorescence signal revealed by this process is specific and exhibited in the near red spectrum region.

Abstract: A hybrid waveguide device includes a hollow core fiber having a core formed by a combination of solid material and gases. The hybrid nature of the core allows the hybrid device to transport a high energy high power laser beam having an ultra-short pulse width without damage to the hybrid device due to a higher tolerance of irradiance than single-matter cores. A waveguide device having a core with gases in addition to solid matter is characterized by a lower nonlinear refractive index coefficient (n2), lower numerical aperture, larger delivering laser beam size, and higher ionization potential of the gases. As a result, the hybrid waveguide fiber can transport ultra-short laser pulses having ablative energy levels and power levels, for example from a laser generating subassembly to a laser material-modification subassembly.

Abstract: Various embodiments described include optical fiber designs and fabrication processes for ultra high numerical aperture optical fibers (UHNAF) having a numerical aperture (NA) of about 1. Various embodiments of UHNAF may have an NA greater than about 0.7, greater than about 0.8, greater than about 0.9, or greater than about 0.95. Embodiments of UHNAF may have a small core diameter and may have low transmission loss. Embodiments of UHNAF having a sufficiently small core diameter provide single mode operation. Some embodiments have a low V number, for example, less than 2.4 and large dispersion. Some embodiments of UHNAF have extremely large negative dispersion, for example, less than about ?300 ps/nm/km in some embodiments. Systems and apparatus using UHNAF are also disclosed.

Abstract: Included among the many structures described herein are photonic bandgap fibers designed to provide a desired dispersion spectrum. Additionally, designs for achieving wide transmission bands and lower transmission loss are also discussed. For example, in some fiber designs, smaller dimensions of high index material in the cladding and large core size provide small flat dispersion over a wide spectral range. In other examples, the thickness of the high index ring-shaped region closest to the core has sufficiently large dimensions to provide negative dispersion or zero dispersion at a desired wavelength. Additionally, low index cladding features distributed along concentric rings or circles may be used for achieving wide bandgaps.

Abstract: Updating an Internet Protocol (IP) address database includes: obtaining transaction address data from a transaction information database, the transaction address data including IP address information and geographical address information received during user transactions; processing the transaction address data to identify specific transaction address data that have overlapping geographical address information and contiguous IP addresses; and updating the IP address database according to the overlapping geographical address information and the contiguous IP addresses.

Abstract: Included among the many structures described herein are photonic bandgap fibers designed to provide a desired dispersion spectrum. Additionally, designs for achieving wide transmission bands and lower transmission loss are also discussed. For example, in some fiber designs, smaller dimensions of high index material in the cladding and large core size provide small flat dispersion over a wide spectral range. In other examples, the thickness of the high index ring-shaped region closest to the core has sufficiently large dimensions to provide negative dispersion or zero dispersion at a desired wavelength. Additionally, low index cladding features distributed along concentric rings or circles may be used for achieving wide bandgaps.