Patents by Inventor Xiangao Sun

Xiangao Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE SILENCING AGENTS FOR TARGETING CORONAVIRUS GENES AND USES THEREOF
    Publication number: 20230138103
    Abstract: The present invention provides gene silencing agents that are capable of silencing the expression of the Coronavirus gene(s), e.g., SARS-CoV-2, both in vitro and in vivo. The present invention further provides general and specific compositions and methods of using such compositions that can be used to reduce specific SARS-CoV-2 protein levels or SARS-CoV-2 titers, in a subject, e.g., a mammal such as a human, for research or therapeutic purposes, for example to manage or treat conditions related to Coronavirus infection, e.g., COVID-19.
    Type: Application
    Filed: March 18, 2021
    Publication date: May 4, 2023
    Inventors: Chiang J. LI, Xiangao SUN, Charles LI, Pingping "Peter" KUANG
  • Compositions of Asymmetric Interfering RNA and Uses Thereof
    Publication number: 20210301292
    Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
    Type: Application
    Filed: April 22, 2021
    Publication date: September 30, 2021
    Inventors: Chiang Jia LI, Xiangao SUN, Harry ROGOFF, Youzhi LI
  • Compositions of asymmetric interfering RNA and uses thereof
    Patent number: 11015195
    Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: May 25, 2021
    Assignee: 1GLOBE HEALTH INSTITUTE LLC
    Inventors: Chiang Jia Li, Xiangao Sun, Harry Rogoff, Youzhi Li
  • Compositions of asymmetric interfering RNA and uses thereof
    Patent number: 10927376
    Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: February 23, 2021
    Assignee: 1GLOBE HEALTH INSTITUTE LLC
    Inventors: Chiang Jia Li, Xiangao Sun, Harry Rogoff, Youzhi Li
  • Compositions of Asymmetric Interfering RNA and Uses Thereof
    Publication number: 20200071696
    Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
    Type: Application
    Filed: March 11, 2019
    Publication date: March 5, 2020
    Inventors: Chiang Jia LI, Xiangao SUN, Harry ROGOFF, Youzhi LI
  • Compositions of Asymmetric Interfering RNA and Uses Thereof
    Publication number: 20200063128
    Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
    Type: Application
    Filed: February 20, 2019
    Publication date: February 27, 2020
    Inventors: Chiang Jia LI, Xiangao SUN, Harry ROGOFF, Youzhi LI
  • Compositions of asymmetric interfering RNA and uses thereof
    Patent number: 10266821
    Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: April 23, 2019
    Assignee: 1GLOBE HEALTH INSTITUTE LLC
    Inventors: Chiang Jia Li, Xiangao Sun, Harry Rogoff, Youzhi Li
  • COMPOSITIONS OF ASYMMETRIC INTERFERING RNA AND USES THEREOF
    Publication number: 20160304868
    Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
    Type: Application
    Filed: March 25, 2016
    Publication date: October 20, 2016
    Inventors: Chiang Jia LI, Xiangao Sun, Harry Rogoff, Youzhi Li
  • Compositions of asymmetric interfering RNA and uses thereof
    Patent number: 9328345
    Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: May 3, 2016
    Assignee: 1 GLOBE HEALTH INSTITUTE LLC
    Inventors: Chiang Jia Li, Xiangao Sun, Harry Rogoff, Youzhi Li
  • Compositions of asymmetric interfering RNA and uses thereof
    Publication number: 20090208564
    Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.
    Type: Application
    Filed: August 27, 2008
    Publication date: August 20, 2009
    Inventors: Chiang Jia Li, Xiangao Sun, Harry Rogoff, Youzhi Li
  • Compositions for modulation of PARP and methods for screening for same
    Publication number: 20060204981
    Abstract: The present invention relates a method for screening for a PARP activator. The screening method comprises the step of assessing the PARP-activating effect of a test compound, using cells, cell lysate, or purified PARP. The present invention also provides a method for the treatment of cancers. The treatment method comprises administering to the subject a therapeutically effective amount of a PARP activator.
    Type: Application
    Filed: January 9, 2006
    Publication date: September 14, 2006
    Inventors: Chiang Li, Aijin Wang, Xiangao Sun